Association of Maternal Opioid Use in Pregnancy With Adverse Perinatal Outcomes in Ontario, Canada, From 2012 to 2018

Corsi, Daniel J.; Hsu, Helen; Fell, Deshayne B.; Wen, Shi Wu; Walker, Mark

doi:10.1001/jamanetworkopen.2020.8256

Cited by 42 publications

(33 citation statements)

References 43 publications

(88 reference statements)

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“…From 2000 to 2016, the incidence of NAS increased from 1.2 to 8.8 per 1000 hospital births in the USA. Similar increases are noted in other countries (Corsi et al 2020, Davies et al 2016. Consequently, an increase of 10,000 infants was noted from 2011 to 2017 in the US foster care system (Patrick et al 2019).…”

Section: Introductionsupporting

confidence: 73%

Infants, children, and youth in foster care with prenatal substance exposure: a synthesis of two scoping reviews

Marcellus

Badry

2021

International Journal of Developmental Disabilities

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Background: Infants, children, and youth in foster care have frequently experienced prenatal substance exposure (PSE), neglect, and maltreatment as well as disruptions in their relationships with families. They also have great capacity for overcoming early adversities. In this synthesis of two previously conducted scoping reviews, we aimed to identify and describe literature that identifies a range of interventions that support the health and development of this population. Methods: This review integrates and extends two previously conducted scoping reviews, one focusing on infants and one focusing on children and youth, to synthesize themes across these developmental stages. The Joanna Briggs Institute scoping review methodology was employed for the current and previous reviews. A three-step search strategy identified published studies in the English language from January 2006 to February 2020. Results: One-hundred and fifty-three sources were included in this review. Four themes were identified: (1) early screening, diagnosis, and intervention; (2) providing theoretically grounded care; (3) supporting parents and foster care providers; and (4) intersectoral collaboration. Conclusion: Infants, children, and youth with PSE are overrepresented in foster care. Child welfare system planning should take a multi-sectoral approach to addressing the cumulative needs of this population and their care providers over developmental ages and stages. Although research remains limited, early screening, diagnosis, and developmentally and FASD-informed intersectoral interventions are critical for optimizing outcomes.

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Section: Introductionsupporting

confidence: 73%

Infants, children, and youth in foster care with prenatal substance exposure: a synthesis of two scoping reviews

Marcellus

Badry

2021

International Journal of Developmental Disabilities

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“…Therefore, delivery and newborn care may occur far from a woman's home, workplace and community support network, imposing financial hardship and social strain. Here, we consider non‐prescribed and OAMT together, as preliminary data from Ontario suggest that women's socio‐demographic and medical/mental health profile on chronic prescription opioids compared with OAMT are similar 17 …”

Section: Resultsmentioning

confidence: 99%

“…The authors had important concerns regarding the quality of the studies, high risk of bias, and the lack of generalizability and comparison groups. A more recent analysis of a population‐based birth registry in Ontario, Canada, found associations between opioid use in pregnancy and adverse pregnancy outcome, including preterm birth 17 . In this cohort of 710,911 women (more than 8,000 with prenatal opioid use), the adjusted relative risk for preterm birth before 37 weeks' gestation was 1.63 (95% CI, 1.52‐1.75) among women with opioid use compared with non‐use, and 1.77 (95% CI, 1.35‐2.31) for preterm birth before 32 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…In pregnancy, women with an opioid use disorder may be managed by opioid agonist maintenance treatment (OAMT). This strategy uses methadone or buprenorphine (buprenorphine/naloxone or mono‐product) to reduce pregnancy complications associated with withdrawal and improve outcomes for mother‐infant dyads 15‐17 . Methadone is a long‐acting competitive mu‐receptor agonist, while buprenorphine is a partial mu‐opioid receptor agonist 2 .…”

Section: Introductionmentioning

confidence: 99%

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The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review

Corsi

Murphy

2021

Basic Clin Pharma Tox

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Opioids cover a broad class of natural, synthetic and semi‐synthetic drugs that act on opioid receptors to produce powerful analgesic effects. Rates of opioid use and opioid agonist maintenance treatment have increased substantially in recent years, particularly among women. Trends and outcomes of opioids use on fertility, pregnancy and breastfeeding, and longer‐term child developmental outcomes have not been well‐described. Here, we review the existing literature on the health effects of opioid use on female fertility, pregnancy, breastmilk and the exposed infant. We find that the current literature is primarily concentrated on the impact of opioid use in pregnancy and neonatal outcomes, with little exploration of effects on fertility. Studies are limited in number, some with small sample sizes, and many are hampered by methodological challenges related to confounding and other potential biases. Opioid use is becoming more prevalent due to environmental pressures such as COVID‐19. More research is needed to better elucidate its effects on reproductive health among younger women and support the development of evidence‐based recommendations for safe prescription practices and public health messaging.

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“…Despite the growing evidence for harmful effects of cannabis use during pregnancy, many pregnant women who report using cannabis also report low perceptions of harm (Sarrafpour et al, 2020). Specifically, 70% of pregnant women reported perceiving that there was "no risk" or "slight risk" if women use cannabis 1-2 times per week during pregnancy (Ko et al, 2018;Corsi et al, 2020). Perceived risk has declined over the past two decades, while both the acceptance and prevalence of use by pregnant women has increased (Ashford et al, 2019).…”

Section: Stress and Cannabis Use During Pregnancymentioning

confidence: 99%

Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping

Al’Absi

Allen

2021

Front. Psychol.

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Although research has only recently started to examine the impact of cannabis use on stress response, there is some evidence that indicates acute and chronic impacts of cannabis on these processes. In this paper, we review processes involved in regulating the stress response and we review the influence of acute and chronic exposure to cannabis on patterns and regulation of the stress response. We also highlight the role of stress as a risk factor for initiation and maintenance of cannabis use. In this context, we examine moderating variables, including sex and life adversity. In light of recent observations indicating increasing prevalence of cannabis use during pregnancy, we provide additional focus on cannabis use in this vulnerable population, including how acute and chronic stress may predispose some individuals to use cannabis during pregnancy. While this line of research is in its infancy, we review available articles that focus on the perinatal period and that examined the association between cannabis use and various life stressors, including partner violence, job loss, and lack of housing. We also review psychiatric co-morbidities (e.g., post-traumatic stress disorder, anxiety). A better understanding of the way stress and cannabis use relate within the general population, as well as within certain subgroups that may be at a greater risk of using and/or at greater risk for adverse outcomes of use, may lead to the development of novel prevention and intervention approaches.

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Association of Maternal Opioid Use in Pregnancy With Adverse Perinatal Outcomes in Ontario, Canada, From 2012 to 2018

Cited by 42 publications

References 43 publications

Infants, children, and youth in foster care with prenatal substance exposure: a synthesis of two scoping reviews

Infants, children, and youth in foster care with prenatal substance exposure: a synthesis of two scoping reviews

The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review

Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping

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