Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior

Ss, Lee; Chronis‐Tuscano, Andrea; Keenan, Kate; Pelham, WE; Loney, Jan; Hulle, CA Van; Lahey, B. B.

doi:10.1038/mp.2008.102

Cited by 78 publications

(57 citation statements)

References 66 publications

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“…Yet, to the best of our knowledge, research on how parental genes moderate the influence of the child behavior on parenting is rare and has never included a sample of fathers (Kaitz et al., 2010; Lee et al., 2008; Morgan, Hammen, & Lee, 2016). Lee et al.…”

Section: Introductionmentioning

confidence: 99%

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Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

Avinun

Knafo‐Noam

2017

Brain and Behavior

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BackgroundParental warmth has been associated with various child behaviors, from effortful control to callous‐unemotional traits. Factors that have been shown to affect parental warmth include heritability and child behavior. However, there is limited knowledge about which specific genes are involved, how they interact with child behavior, how they affect differential parenting, and how they affect fathers. We examined what affects paternal and maternal warmth by focusing on the child's prosocial behavior and parents’ genotype, specifically a Valine to Methionine substitution at codon 66 in the brain‐derived neurotrophic factor (BDNF) gene.MethodsData was available from a sample of 6.5 year‐old twins, consisting of 369 mothers and 663 children and 255 fathers and 458 children. Self‐reports were used to assess mothers’ and fathers’ warmth. Child prosociality was assessed with the other‐parent report and experimental assessments.ResultsMothers’ warmth was not affected by their BDNF genotype, neither as a main effect nor in an interaction with child prosociality. Fathers with the Met allele scored higher on warmth. Additionally, there was a significant interaction between fathers’ BDNF genotype and child prosociality. For fathers with the Met allele there was a positive association between warmth and child prosociality. Conversely, for fathers with the Val/Val genotype there was no association between warmth and child prosociality. Results were repeated longitudinally in a subsample with data on age 8–9 years. A direct within family analysis showed that fathers with the Met allele were more likely than Val/Val carriers to exhibit differential parenting toward twins who differed in their prosocial behavior. The same pattern of findings was found with mother‐rated and experimentally assessed prosociality.ConclusionsThese results shed light on the genetic and environmental underpinnings of paternal behavior and differential parenting.

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Section: Introductionmentioning

confidence: 99%

“…Lee et al. (2008), have found that mothers’ dopamine transporter genotype is associated with negative parenting. This association was significantly stronger among mothers whose children were highly disruptive.…”

Section: Introductionmentioning

confidence: 99%

Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

Avinun

Knafo‐Noam

2017

Brain and Behavior

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“…For instance, early maternal sensitivity has been positively associated with later aggressive responses, and early maternal depressive symptoms have been positively associated with children's negative attributions (Raikes and Thompson, 2008). Moreover, MC behavior appears to be tightly related with DA signaling in animals (Byrnes et al, 2002;Miller and Lonstein, 2005;Numan et al, 2005) and in humans (Lee et al, 2010), especially in dorsal and ventral striatal areas (Pruessner et al, 2004). All together, these data suggest that emotion processing, MC and DA signaling are strongly interconnected in modulating brain physiology.…”

Section: Introductionmentioning

confidence: 70%

“…The 10-repeat allele has been associated with greater levels of DAT expression (Heinz et al, 2000;Fuke et al, 2001;Mill et al, 2002;VanNess et al, 2005), although data in the opposite direction have also been reported (van Dyck et al, 2005). This polymorphism has also been associated with prefrontal and hippocampal activity during performance of cognitive tasks (Bertolino et al, 2006;Bertolino et al, 2008;Prata et al, 2009a;Prata et al, 2009b), with anxiety traits (Hunnerkopf et al, 2007) and with quality of parenting (Lee et al, 2010). More in detail, the DAT 3 0 VNTR 10 allele predicts greater scores for negative parenting in mothers when their offspring with ADHD symptoms present high child deviance (Lee et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

DATby perceived MC interaction on human prefrontal activity and connectivity during emotion processing

Taurisano

Blasi

Romano

et al. 2012

Social Cognitive and Affective Neuroscience

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Background: Maternal care (MC) and dopamine modulate brain activity during emotion processing in inferior frontal gyrus (IFG), striatum and amygdala. Reuptake of dopamine from the synapse is performed by the dopamine transporter (DAT), whose abundance is predicted by variation in its gene (DAT 3 0 VNTR; 10 > 9-repeat alleles). Here, we investigated the interaction between perceived MC and DAT 3 0 VNTR genotype on brain activity during processing of aversive facial emotional stimuli. Methods: Sixty-one healthy subjects were genotyped for DAT 3 0 VNTR and categorized in low and high MC individuals. They underwent functional magnetic resonance imaging while performing a task requiring gender discrimination of facial stimuli with angry, fearful or neutral expressions. Results: An interaction between facial expression, DAT genotype and MC was found in left IFG, such that low MC and homozygosity for the 10-repeat allele are associated with greater activity during processing of fearful faces. This greater activity was also inversely correlated with a measure of emotion control as scored with the Big Five Questionnaire. Moreover, MC and DAT genotype described a double dissociation on functional connectivity between IFG and amygdala. Conclusion: These findings suggest that perceived early parental bonding may interact with DAT 3 0 VNTR genotype in modulating brain activity during emotionally relevant inputs.

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“…For example, a study by Lee et al (2010) have found a significant association between the presence of 9/10 genotype of maternal DAT1 gene with both negative parenting and children disruptive behaviour. Mothers with the 9/10 genotype had more difficulties in parenting,…”

Section: Dat Genotype-environment Interactionmentioning

confidence: 99%

Dopamine Transporter And Transmission Of Psychopathological Risk. A Review Of Gene-Environment Interplay

Marzilli¹,

Ballarotto²,

Cimino³

et al. 2017

European Proceedings of Social and Behavioural Sciences

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Research underlines that intergenerational transmission of psychopathological risk results from a complex interplay of genetic and environmental risk factors which predispose child to develop emotionalbehavioral problems. Mechanisms of transmission are poorly understood, but few studies have focused on the role played by dopamine transporter (DAT) gene. This review aims to examine mediating mechanism of DAT genotype-environmental interaction (GxE), DAT genotype-environmental correlation (rGE), and methylation status involved in transmission of psychopathological risk. The review of literature was made through researches in university libraries on paper material, and telematics systems research. Studies have evidenced that DAT is implicated in intergenerational transmission of psychopathological risk. Results are mixed regarding its genetic variants, but mechanisms through which this gene can affect both quality of parenting and child development are partially established. Only few studies have examined methylation mechanisms that can be implicated. Findings suggest to involve an improved focus on DAT genotypes, methylation status associated, and their relationship with environment to better understanding child's vulnerability and resilience following exposure to contextual risk factors associated with parental psychopathological symptoms.

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Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior

Cited by 78 publications

References 66 publications

Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth

DATby perceived MC interaction on human prefrontal activity and connectivity during emotion processing

Dopamine Transporter And Transmission Of Psychopathological Risk. A Review Of Gene-Environment Interplay

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