Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies

Yu, Grace; Aye, Christina; Lewandowski, Adam J.; Davis, Esther; Khoo, Cheen P.; Newton, Laura; Yang, Cheng‐Ta; Zen, Ayman Al Haj; Simpson, Lisa J; O’Brien, Kathryn M.; Cook, David; Granne, Ingrid; Kyriakou, Theodosios; Channon, Keith M.; Watt, Suzanne M.; Leeson, Paul

doi:10.1161/hypertensionaha.116.07586

Cited by 50 publications

(61 citation statements)

References 44 publications

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“…This postulate was recently supported by studies of capillaries in early postnatal infant skin. 20 The PE-F1 deviations of increased brain regional volumes or globally reduced vascular diameters suggest that the legacy impact of PE occurred in regions associated with memory and visual spatial processing. 14,16 Our previous findings that the temporal lobe and right and left amygdalae in PE-F1 are larger than in control children were coincident with the larger DTI volume of white matter in 2 ROIs: the caudate nucleus and superior longitudinal fasciculus (Table).…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations

Figueiró-Filho

Croy²,

Reynolds

et al. 2017

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Individuals born from pregnancies complicated by preeclampsia have an elevated risk for cognitive impairment. Deviations in maternal plasma angiokines occur for prolonged intervals before clinical signs of preeclampsia. We hypothesized that fetal brain vascular and nervous tissue development become deviated during maternal progression toward preeclampsia and that such deviations would be detectable by MR imaging.

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Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations

Figueiró-Filho

Croy²,

Reynolds

et al. 2017

AJNR Am J Neuroradiol

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“…In a study of systemic microvascular density in human infants, 3‐month‐old offspring of hypertensive pregnancies had increased circulating anti‐angiogenic factors and decreased vascularization (Yu et al . ). However, the degree to which VEGF and other angiogenic signalling is impaired later in life after perinatal insults remains unknown.…”

Section: Impaired Pulmonary Vascularizationmentioning

confidence: 97%

Long‐term pulmonary vascular consequences of perinatal insults

Goss

2018

The Journal of Physiology

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Development of the pulmonary circulation is a critical component of fetal lung development, and continues throughout infancy and childhood, marking an extended window of susceptibility to vascular maldevelopment and maladaptation. Perinatal vascular insults may result in abnormal vascular structure or function, including decreased angiogenic signaling and vascular endowment, impaired vasoreactivity through increased pulmonary artery endothelial dysfunction and remodeling, or enhanced genetic susceptibility to pulmonary vascular disease through epigenetic modifications or germline mutations. Although some infants develop early onset pulmonary hypertension, due to the unique adaptive capabilities of the immature host many do not have clinically evident early pulmonary vascular dysfunction. These individuals remain at increased risk for development of late-onset pulmonary hypertension, and may be particularly susceptible to secondary insults. This review will address the role of perinatal vascular insults in the development of late pulmonary vascular dysfunction with an effort to highlight areas of critical research need.

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“…Exposure to a hypoxic intrauterine environment is associated with offspring vascular, metabolic, and cardiac modifications including aortic wall thickening, loss of NO vessel modulation, altered LV function, and increased susceptibility to ischemia and metabolic syndrome [110][111][112]. Recently, it has become apparent that offspring of hypertensive pregnancies may also have microvascular genotypic and phenotypic abnormalities that may persist beyond the perinatal period and into adulthood [113][114][115][116], which may account for their significantly lower threshold for the development of cardiovascular-related diseases [110]. While studies assessing the specific impact of preeclampsia on cardiac remodeling during the transition from fetal to neonatal life remain limited, further investigations are needed given that adolescents and young adults who were exposed to maternal preeclampsia display unique LV remodeling patterns including greater relative wall thickness, smaller internal cavity diameter, and lower longitudinal peak systolic strain [112,117].…”

Section: Impact Of Pregnancy Complications On Early Cardiac Remodelingmentioning

confidence: 99%

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

Tan

Lewandowski²

2019

Fetal Diagn Ther

173

123

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Formation of the human heart involves complex biological signals, interactions, specification of myocardial progenitor cells, and heart tube looping. To facilitate survival in the hypoxemic intrauterine environment, the fetus possesses structural, physiological, and functional cardiovascular adaptations that are fundamentally different from the neonate. At birth, upon separation from the placental circulation, the neonatal cardiovascular system takes over responsibility of vital processes for survival. The transition from the fetal to neonatal circulation is considered to be a period of intricate physiological, anatomical, and biochemical changes in the cardiovascular system. With a successful cardiopulmonary transition to the extrauterine environment, the fetal shunts are functionally modified or eliminated, enabling independent life. Investigations using medical imaging tools such as ultrasound and magnetic resonance imaging have helped to define normal and abnormal patterns of cardiac remodeling both in utero and ex utero. This has not only allowed for a better understanding of how congenital cardiac malforma-tions alter the hemodynamic transition to the extrauterine environment but also how other more common complications during pregnancy including intrauterine growth restriction, preeclampsia, and preterm delivery adversely affect offspring cardiac remodeling during this early transitional period. This review article describes key cardiac progenitors involved in embryonic heart development; the cellular, physiological, and anatomical changes during the transition from fetal to neonatal circulation; as well as the unique impact that different pregnancy complications have on cardiac remodeling.

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Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies

Abstract: Supplemental Digital Content is available in the text.

Cited by 50 publications

References 44 publications

Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations

Diffusion Tensor Imaging of White Matter in Children Born from Preeclamptic Gestations

Long‐term pulmonary vascular consequences of perinatal insults

The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life

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