Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease

Genome-wide association study confirms extant PD risk loci among the Dutch

“…This is probably because of the relatively small size of the sample used for these experiments, as this locus is a well-known PD risk locus among Europeans. 5,7,9,23,65,66 If the same hypothesis as that presented for GAK/DGKQ is applied, five out of the nine tested SNPs would be borderline significant (in the range of 10 À3 ) supporting a role of this locus in the development of PD among the Dutch.…”

Genetic Analysis of Pathways to Parkinson Disease

“…While tau pathology is sometimes found in Parkinson disease, it is not pathognomic. Furthermore the haplotype that is associated with Parkinson disease is distinct from that associated with the tangle disorder, progressive supranuclear palsy (Vandrovcova et al., 2009). Indeed, strictly, we cannot be sure that the association is with tau since the large haplotype that is associated with Parkinson disease has many other genes upon it (Fung et al., 2005).…”

Polygenic determinants of Parkinson's disease in a Chinese population

“…It has been reported that some polymorphisms are associated with the risk of PD, such as Rep1, rs356165, and rs11931074 in SNCA gene (Mueller et al, 2005;Satake et al, 2009;Simón-Sánchez et al, 2009;Tan et al, 2010a); G2385R and R1628P in LRRK2 gene Tan et al, 2010aTan et al, , 2010b; rs242562 and rs2435207 in MAPT gene (Skipper et al, 2004;Vandrovcova et al, 2009); and L444P in GBA gene (Sidransky et al, 2009;Sun et al, 2010). More recently, genomewide association studies (GWASs) of complex diseases have identified sequence variants that are consistently associated with the risk of such diseases.…”