Association of Male Infertility to Metabolic Syndrome and Other Related Disorders

Kumar, Sanjay; Agrawal, Divya; Sharma, Kunal; Swain, Trupti Rekha

doi:10.4103/2225-1243.168524

Cited by 7 publications

(15 citation statements)

References 2 publications

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“…Antiobesity strategies need to overcome the strong homeostatic mechanisms driving reduced energy expenditure. Accordingly, much effort has been devoted in this front during the last two decades, with the recognition of the major metabolic roles of numerous neuropeptides and transmitters, as well as multiple peripheral hormones [6][7][8], not only in the regulation of feeding, but also in the modulation of energy expenditure.…”

Section: Amino Acidslevels In Rats Under Progesterone Long-term Adminmentioning

confidence: 99%

“…За різними оцінками поширеність МС серед підлітків та молоді складає біля 10 %, зростаючи до 22,1 % при вираженому ожирінні [5,6]. Серед потенційних ризиків для здоров'я, пов'язаних з розвитком МС та ожиріння, на особливу увагу заслуговує те, що вони можуть негативно впливати на репродуктивну систему [7,8].…”

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Age features of metabolic syndrome effects on fetal embryonic development of the male rat offsprings

Tkachenko

Коваленко

2016

BTSNUKSPPFR

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Comparative study of embryo-fetal death in females fertilized by males with metabolic syndrome, induced in adult or juvenile age has shown that the offspring of adult rats did not have significant abnormalities in embrio- and fetogenesis. At the same time it has been revealed 4% postimplantation death of offspring in male rats with metabolic syndrome induced in the juvenile age. The pre-implantation loss in this group was 6 folds higher than in control. Accordingly, the total mortality of the offspring rose 2.4 times in comparison with control.

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Section: Amino Acidslevels In Rats Under Progesterone Long-term Adminmentioning

confidence: 99%

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Age features of metabolic syndrome effects on fetal embryonic development of the male rat offsprings

Tkachenko

Коваленко

2016

BTSNUKSPPFR

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“…Obesity and diabetes are recognised as detrimental factors in human fertility. Dyslipidaemia and its related high free fatty acids may be a leading cause to endothelial dysfunction through the higher production of free radicals and also through the inhibition of nitric oxide (NO) synthesis (Kumar, Agrawal, Sharma, & Swain, 2015). One of the key players of metabolic syndrome pathogenesis is insulin resistance (Eckel, Alberti, Grundy, & Zimmet, 2010).…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance and idiopathic infertility: A potential possible link

et al. 2020

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Among various health issues, infertility has been always considered as one of the major health problems. Idiopathic infertility is still a matter of debate since the underlying mechanisms stay obscure. Idiopathic infertility is related to expanded chance of metabolic syndrome components, obesity and increased risk of cardiovascular diseases. This study aimed to assess insulin resistance and serum levels of irisin as one of the adipokines in patients with idiopathic infertility. This study included 50 male patients aged 25–50 years old suffering from idiopathic infertility, together with 50 healthy individuals of matched age as controls. Patients showed significantly increased homeostasis model assessment for insulin resistance values than controls. For irisin results, idiopathic infertility patients had significantly decreased values than controls indicating the potential effect of irisin in development of insulin resistance in idiopathic infertility patients.

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“…In the setting of increased prevalence of metabolic syndrome worldwide, many studies were done to reveal the potential relationship between metabolic syndrome and male factor infertility aiming to provide new therapeutic options for infertile males (Ediz & Altıntas, ; Kumar, Agrawal, Sharma, & Swain, ).…”

Section: Introductionmentioning

confidence: 99%

“…The impaired glucose metabolism is widely accepted as a negative effecting factor on human fertility. Dyslipidemia and its associated elevated free fatty acids in metabolic syndrome can cause endothelial dysfunction through increased free radical production and inhibition of nitric oxide (NO) synthesis (Kumar et al., ).…”

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction marker YKL-40 is elevated in male patients with idiopathic infertility

Hanafy

Sabry

et al. 2018

Andrologia

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Metabolic syndrome represents a collection of cardiovascular risk factors, including overweight, hypertension, dyslipidemia and impaired glucose metabolism, with insulin resistance. In recent years, the potential relationship between metabolic syndrome and male factor infertility has been studied. As endothelial dysfunction is the hallmark of metabolic syndrome, the aim of this work was to assess serum levels of YKL-40 as a marker of endothelial dysfunction in male patients with idiopathic infertility. The study revealed that YKL-40 levels were elevated in patients than controls denoting that endothelial dysfunction might play a role in the pathogenesis of idiopathic infertility and that YKL-40 as a marker of endothelial dysfunction could be a useful marker of idiopathic infertility.

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Association of Male Infertility to Metabolic Syndrome and Other Related Disorders

Cited by 7 publications

References 2 publications

Age features of metabolic syndrome effects on fetal embryonic development of the male rat offsprings

Age features of metabolic syndrome effects on fetal embryonic development of the male rat offsprings

Insulin resistance and idiopathic infertility: A potential possible link

Endothelial dysfunction marker YKL-40 is elevated in male patients with idiopathic infertility

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