Association of male factors with recurrent pregnancy loss

Yu, Wu; Bao, Shihua

doi:10.1016/j.jri.2022.103758

Cited by 2 publications

(2 citation statements)

References 69 publications

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“…Генетические маркёры включают в себя аномалии количества и структуры хромосом, микроделеции Y-хромосом, эпигенетические факторы и полимор-Y-хромосом, эпигенетические факторы и полимор--хромосом, эпигенетические факторы и полиморфизмы генов. Негенетические факторы представлены в первую очередь ДНК-фрагментацией сперматозоидов, возрастом отца, отклонениями в параметрах спермограммы и образом жизни (ожирением, курением и наличием хронических заболеваний) [61]. И если генетические факторы непосредственно влияют на риски потери беременности, то роль фрагментации ДНК сперматозоидов остается спорной в связи с отсутствием стандартизированного определения «высокой» фрагментации [62] Изучение негенетических факторов показало относительно более высокое количество провоспалительных цитокинов в семенной плазме мужчин из пар, страдающих привычным выкидышем.…”

Section: мужской фактор невынашивания беременности и роль оксидативно...unclassified

“White spots” in the diagnostic search for the causes of recurrent miscarriage

Lebedenko,

Mikhelson,

Mikhelson

et al. 2024

Med. vestn. Ûga Ross.

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Recurrent pregnancy loss is not only a medical, but also a social problem of a multifactorial nature. This problem remains unsolvable despite the constant search and application of new diagnostic and therapeutic strategies. The presented review examines the literature data on evidence-based methods for diagnosing the causes of miscarriage, as well as methods whose use remains controversial. Special attention is paid to the immunological foundations of a normal pregnancy formation, the violation of which creates the prerequisites for a recurrent miscarriage. The paper also analyzes current data on the role of endometrial receptivity and the contribution of the male factor to the problem of miscarriage, and presents prospects for further research on the problem of recurrent pregnancy loss.

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Section: мужской фактор невынашивания беременности и роль оксидативно...unclassified

“White spots” in the diagnostic search for the causes of recurrent miscarriage

Lebedenko,

Mikhelson,

Mikhelson

et al. 2024

Med. vestn. Ûga Ross.

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“…The Royal College of Obstetricians and Gynaecologists has defined RM as three or more spontaneous miscarriages, while the American Society of Reproductive Medicine and the European Society of Human Reproduction and Embryology both defined RM as two or more failures of pregnancy (ESHRE Guideline Group on RPL, 2018; Green & O'Donoghue, 2019; Practice Committee of the American Society for Reproductive Medicine, 2012). The potential etiologies of RM are quite complex and include male factors (such as male partner's sperm quantity, sperm quality, and genetic mutations), and genetic abnormality, anatomic issues, and immune disorders (Deshmukh & Way, 2019; Quenby et al, 2021; Yu & Bao, 2022). Therefore, the treatment of RM also varies greatly and includes surgery, immunotherapies, anticoagulants, endocrine therapies, etc.…”

Section: Introductionmentioning

confidence: 99%

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

Huo

Wang

et al. 2023

Food Science & Nutrition

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Recurrent miscarriage (RM) affects approximately 1%–5% of couples worldwide. Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. However, these treatment modalities are still insufficient to solve RM. Omega‐3 fatty acids are reported to modulate the dysregulation of immune cells, oxidative stress, endocrine disorders, inflammation, etc., which are closely associated with the pathogenesis of RM. However, there is a lack of a systematic description of the involvement of omega‐3 fatty acids in treating RM, and the underlying mechanisms are also not clear. In this review, we sought to determine the potential mechanisms that are highly associated with the pathogenesis of RM and the regulation of omega‐3 fatty acids on these mechanisms. In addition, we also highlighted the direct and indirect clinical evidence of omega‐3 fatty acid supplements to treat RM, which might encourage the application of omega‐3 fatty acids to treat RM, thus improving pregnancy outcomes.

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Association of male factors with recurrent pregnancy loss

Cited by 2 publications

References 69 publications

“White spots” in the diagnostic search for the causes of recurrent miscarriage

“White spots” in the diagnostic search for the causes of recurrent miscarriage

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

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