Association of Major Depressive Episode with Negative Outcomes of Tuberculosis Treatment

Ugarte-Gil, César; Ruiz, P.; Zamudio, Carlos; Canaza, Luz; Otero, Larissa; Krüger, H; Seas, Carlos

doi:10.1371/journal.pone.0069514

Cited by 57 publications

(84 citation statements)

References 32 publications

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“…A retrospective cohort analysis of 440 TB patients has revealed a high rate of relapse due to poor medication compliance, and psychiatric disorders have been implicated29. Several factors were significantly associated with depression in persons with a TB diagnosis, like personal, socio-demographic (age and financial status), environmental, and clinical (persistent cough)28. In our study, low self-esteem and current smoking were significantly associated depression.…”

Section: Discussionsupporting

confidence: 49%

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Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

2017

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BackgroundMuch of the attention of tuberculosis (TB) programs is focused on outcomes of microbiological cure and mortality, and health related quality of life (HRQL) is undervalued. Also, TB patients have a significantly higher risk of developing depression and anxiety compared with those in the general population. We intend to evaluate the HRQL and the prevalence of symptoms of depression and anxiety in hospitalized patients with TB.MethodsCross-sectional study in a tertiary care hospital in Brazil. Adult patients with pulmonary TB that were hospitalized during the study period were identified and invited to participate. HRQL was measured using the Medical Outcomes Study Short Form-36 (SF-36) version 2. Hospital Anxiety and Depression Scale (HADS) was used to record symptoms of anxiety and depression.ResultsEighty-six patients were included in the analysis. The mean age of all patients was 44.6±15.4 years, 69.8% were male, and 53.5% were white. Thirty-two patients (37.2%) were human immunodeficiency virus positive. Twenty-seven patients (31.4%) met study criteria for depression (HADS depression score ≥11) and 33 (38.4%) had anxiety (HADS anxiety score ≥11). Scores on all domains of SF-36 were significantly lower than the Brazilian norm scores (p<0.001).ConclusionThe present study shows that TB patients may have a poor HRQL. Additionally, we found a possible high prevalence of depression and anxiety in this population. Health care workers should be aware of these psychological disorders to enable a better management of these patients. The treatment of these comorbidities may be associated with better TB outcomes.

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Section: Discussionsupporting

confidence: 49%

“…Depressive disorder in TB patients has been recognized as a cause of poor treatment compliance and poor disease outcomes, like treatment default or death28. A retrospective cohort analysis of 440 TB patients has revealed a high rate of relapse due to poor medication compliance, and psychiatric disorders have been implicated29.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

2017

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“…This measure was developed based on evidence that shorter versions have adequate psychometric properties for identifying depression [25, 26], and previous experience using shorter versions of this tool in Peru do exits [27]. Briefly, depressive mood was evaluated for the seven days preceding the survey, thus referring to current or active depressive mood, consistent with the clinical diagnosis of major depressive episode.…”

Section: Methodsmentioning

confidence: 99%

Depressive Mood Among Within-Country Migrants in Periurban Shantytowns of Lima, Peru

Ruíz-Grosso

Bernabé‐Ortiz

Diez-Canseco

et al. 2014

J Immigrant Minority Health

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In low- and middle-income countries, migration to urban settings has reshaped the sprawl and socio demographic profiles of major cities. Depressive episodes make up a large portion of the burden of disease worldwide and are related to socio-demographic disruptions. As a result of terrorism, political upheaval, followed by economic development, Peru has undergone major demographic transitions over the previous three decades including large migrations within the country. We aimed to determine the prevalence of current depressive mood and its relationship with parameters of internal migration, i.e. region of origin, age at migration, and years since migration. A community-wide census was carried out between January and June 2010 within a shantytown immigrant receiving community in Lima, Peru. One male or female adult per household completed a survey. Depressive mood was assessed with a 2-item Center for Epidemiologic Studies Depression (CESD) scale. Migration-related variables included place of birth, duration of residence in Lima, and age at migration. Prevalence ratios (PR) and 95% confidence intervals (95%CI) were calculated. A total of 8 551 out of 9 561 participants, response rate 89%, participated in the census. Of these, 8 091 records were analyzed: 71.8% were women (average age 39.4 [SD: 13.9 years]) and 59.3% were immigrants. The overall prevalence of individuals with current depressive mood was 17.1% (95%CI: 16.2% – 17.9%) and varied significantly by all socio-demographic and migration variables assessed. On unadjusted analyses, immigrants to Lima had higher prevalence of depressive mood if they originated in other costal or Andean areas, had lived in Lima for more than 20 years, or were less than 30 years of age when they out-migrated. When controlling for age, gender and socio-demographic variables the association was no longer significant, the only exception being a 20% lower prevalence of current depressive mood among those who out-migrated aged ≥30 years old (PR = 0.79; 95%CI 0.63 – 0.98). In conclusion, these results suggest that current depressive mood is very prevalent in this immigrant receiving community. Among all proxies for internal migration explored, in fully adjusted models, there was evidence of an association between age at migration (≥30 years old) and a lower probability of current depressive mood compared to non-migrants.

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“…Tuberculosis and psychiatric disorders may share many common risk factors like homelessness, HIV positive status, alcohol or substance abuse and migrant status. TB is also associated with negative outcomes when there is a major depressive episode present at baseline 19 (Ugarte-Gil, C., 2013). Non-adherence to treatment is considered as the principal hurdle in eliminating TB 20 (Prince, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…14,15,16,17 Prevalence of psychiatric illnesses in tuberculosis is high not only during treatment, but a significant proportion of patients have been found to be at risk for depression even at the end of tuberculosis treatment 8 (Atif et al, 2014). 18,19,20 Presence of psychiatric illnesses like depression can affect TB outcome through poor compliance 10 (DiMatteo, M. R., 2000). Non-adherence leads to drug resistance 11 (Paramasivan CN.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Morbidity in People With Tuberculosis: A Cross Sectional Study

P.P¹,

Malaiappan²,

Malaiarasan³

2018

jebmh

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BACKGROUND Tuberculosis ranks alongside Human Immunodeficiency Virus as a leading cause of death worldwide. 1,2 Psychiatric disorders in chronic medical illnesses have been found to be associated with poor compliance in previous studies. Poor compliance in tuberculosis can have drastic consequences including emergence of drug resistance. 1,2,3,4,5 In this study, we have attempted to study the prevalence of psychiatric disorders in tuberculosis at a tertiary care centre in Chennai. The objectives of the study were-1. To assess the prevalence of psychiatric illnesses in people undergoing treatment for tuberculosis. 2. To assess the association between psychiatric comorbidity and different socio-demographic factors (age, gender, education) and tuberculosis disease related factors. 3. To assess the relationship between psychiatric comorbidity and negative behavioural factors like history of defaulting. MATERIALS AND METHODS Ours is a cross sectional study conducted at the Department of Thoracic Medicine in Government Kilpauk Medical College, Chennai. A total of 106 patients were interviewed and examined. RESULTS We observed that 63.12% of the patients had at least one psychiatric illness. About 62.6% had depressive disorder. Anxiety disorders were found in 23.5%. We also found significant relationships between the following: male gender and presence of psychiatric illnesses, joint family and presence of psychiatric illnesses, dyspnoea grade 3 or more and presence of psychiatric illnesses, dyspnoea grade 3 or more and severity of depression. CONCLUSION The high prevalence of psychiatric disorders in people with tuberculosis warrants specific screening and management.

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Association of Major Depressive Episode with Negative Outcomes of Tuberculosis Treatment

Cited by 57 publications

References 32 publications

Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis

Depressive Mood Among Within-Country Migrants in Periurban Shantytowns of Lima, Peru

Psychiatric Morbidity in People With Tuberculosis: A Cross Sectional Study

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