Association of Lymphocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke

Chong, Lining; Han, Lin; Liu, Ruqian; Ma, Guomei; Ren, Hao

doi:10.12659/msm.930076

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Therefore, these novel inflammatory indices have attracted a great deal of research interest. To our knowledge, NLR and PLR have been confirmed to be significantly related to the occurrence and development of coronary syndrome, sarcopenia, rheumatoid arthritis and other diseases [ 34 – 37 ], but their value in osteoporosis remains to be firmly established due to the lack of evidence.…”

Section: Discussionmentioning

confidence: 99%

Association between inflammatory markers and bone mineral density: a cross-sectional study from NHANES 2007–2010

et al. 2023

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Purpose Monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are acknowledged as novel inflammatory markers. However, studies investigating the correlation between inflammatory markers and osteoporosis (OP) remain scarce. We aimed to investigate the relationship between NLR, MLR, PLR and bone mineral density (BMD). Methods A total of 9054 participants from the National Health and Nutrition Examination Survey were included in the study. MLR, NLR and PLR were calculated for each patient based on routine blood tests. Given the complex study design and sample weights, the relationship between inflammatory markers and BMD was evaluated through weighted multivariable-adjusted logistic regression and smooth curve fittings. In addition, several subgroup analyses were conducted to assess the robustness of the outcomes. Results This study observed no significant relationship between MLR and lumbar spine BMD (P = 0.604). However, NLR was positively correlated with lumbar spine BMD (β = 0.004, 95% CI: 0.001 to 0.006, P = 0.001) and PLR was negatively linked to lumbar spine BMD (β = − 0.001, 95% CI: − 0.001 to − 0.000, P = 0.002) after accounting for covariates. When bone density measurements were changed to the total femur and femoral neck, PLR was still significantly positively correlated with total femur (β = − 0.001, 95% CI: − 0.001, − 0.000, P = 0.001) and femoral neck BMD (β = − 0.001, 95% CI: − 0.002, − 0.001, P < 0.001). After converting PLR to a categorical variable (quartiles), participants in the highest PLR quartile had a 0.011/cm2 lower BMD than those in the lowest PLR quartile (β = − 0.011, 95% CI: − 0.019, − 0.004, P = 0.005). According to subgroup analyses stratified by gender and age, the negative correlation with PLR and lumbar spine BMD remained in males and age < 18 groups, but not in female and other age groups. Conclusions NLR and PLR were positively and negatively correlated with lumbar BMD, respectively. And PLR might serve as a potential inflammatory predictor of osteoporosis outperforming MLR and NLR. The complex correlation between the inflammation markers and bone metabolism requires further evaluation in large prospective studies.

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Section: Discussionmentioning

confidence: 99%

Association between inflammatory markers and bone mineral density: a cross-sectional study from NHANES 2007–2010

et al. 2023

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“…However, lymphocyte-to-monocyte ratio (LMR) was an independent protective factor for AIS. Low LMR was significantly associated with poor prognosis for AIS [ 21 , 28 , 49 ], early deterioration of neurological function [ 24 ] and post-stroke depression [ 29 ]. This suggests that leukocytes are functionally diverse in AIS.…”

Section: Effect Of Blood Biomarkers On Prognosis Of Aismentioning

confidence: 99%

Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects

Jiang,

Li,

et al. 2024

Future Science OA

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Acute ischemic stroke (AIS) is one of the most common strokes posing a grave threat to human life and health. Predicting the prognosis of AIS allows for an understanding of disease progress, and a better quality of life by making individualized treatment scheme. In this paper, we conducted a systematic search on PubMed, focusing on the relevant literature in the last 5 years. Summarizing the candidate prognostic biomarkers of AIS in body fluids such as blood, urine, saliva and cerebrospinal fluid is often of great significance for the management of acute ischemic stroke, which has the potential to facilitate early diagnosis, treatment, prevention and long-term outcome improvement.

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Research Progress on the Relationship between NLR, MLR, FAR and Prognosis of AIS Patients Treated with Intravenous Thrombolytic Therapy

詹

2022

ACM

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Association of Lymphocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke

Cited by 5 publications

References 49 publications

Association between inflammatory markers and bone mineral density: a cross-sectional study from NHANES 2007–2010

Association between inflammatory markers and bone mineral density: a cross-sectional study from NHANES 2007–2010

Body fluids biomarkers associated with prognosis of acute ischemic stroke: progress and prospects

Research Progress on the Relationship between NLR, MLR, FAR and Prognosis of AIS Patients Treated with Intravenous Thrombolytic Therapy

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