Association of Lung Function With Atherosclerotic Risk Factors Among Japanese Americans: Seattle Nikkei Health Study

Abstract

1. Impaired lung function has been reported to be associated with mortality from all causes, cardiovascular disease (CVD) and aortic pulse wave velocity (PWV). The aim of the present study was to examine the association between impaired lung function and atherosclerotic risk factors, including PWV, blood pressure, lipids, smoking and alcohol intake, among Japanese Americans. 2. The study subjects were 678 adult Japanese Americans who participated in CVD screening conducted under the Seattle Nikkei Health Study. Subjects with abnormal lung function were defined as those with forced vital capacity (FVC%) < 80% of predicted or forced expiratory volume in 1 s (FEV1%) < 80% of predicted. We conducted logistic regression analyses by using abnormal lung function as dependent variables. 3. The significant predictors positively associated with abnormal FVC% were age (60 years or older) and hypertension. Being a current drinker or an ex-drinker was independently and negatively associated with abnormal FVC%. The significant predictors positively associated with abnormal FEV1% were age (60 years or older), sex (male), hypertension and being a current smoker. Being a current drinker was independently and negatively associated with abnormal FEV1%. 4. In conclusion, the present study does not support the previously reported association of abnormal lung function with PWV. However, our findings imply that light and moderate drinking may be a protective factor of lung function and that hypertension and smoking may impair lung function.

Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease

“…Zureik and coworkers (84) found that PWV was associated with FEV 1 in 194 ostensibly healthy middle-aged men, independent of age, sex, and smoking status, although Taneda and colleagues (85) were unable to replicate this finding in 678 healthy Japanese Americans. Therefore, reduced pulmonary function may be associated with arterial stiffness in healthy individuals.…”

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“…First, low respiratory and cognitive functions are both aff ected by lifestyle behaviors such as smoking and drinking (31,32) as well as cardiovascular risk factors such as diabetes (33) and hypertension (34).…”

Age and cigarette smoking modulate the relationship between pulmonary function and arterial stiffness in heart failure patients

“…The Seattle Nikkei Health Study did not support the previously reported association of abnormal pulmonary function with aortic PWV. [28] Different clinical characteristics of participants may account for the differences in results from various reports. This study indicated for the first time that in CHF patients, CAVI was significantly correlated to FEV 1 after adjusting for confounders, supporting the notion of an association of pulmonary function with arterial stiffness.…”