Association of low serum magnesium with diabetes and hypertension: Findings from Qatar Biobank study

Shi, Zumin; Abou‐Samra, Abdul Badi

doi:10.1016/j.diabres.2019.107903

Cited by 15 publications

(20 citation statements)

References 30 publications

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“…The contribution of diet on serum magnesium levels seems to be small based on a previous study in Qatar. A dietary pattern using a reduced rank regression method with serum magnesium as the response variable can only explain 0.9% of the variance of serum magnesium (Shi and Abou-Samra, 2019). In Qatar, the main source of drinking water is desalinated seawater.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study on 9,693 Qatari adults found that subclinical magnesium deficiency (serum magnesium <0.85 mmol/l) is common. Low circulating magnesium is positively associated with prediabetes, diabetes, and hypertension in Qatari adults (Shi and Abou-Samra, 2019). However, no studies have assessed the relationship between serum magnesium and cognition in Qatar, where the prevalence of diabetes is about ∼19% (Al-Thani et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

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Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali

Eltayeb

Musleh

et al. 2020

Front. Aging Neurosci.

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Background: Previous studies found that low blood magnesium increases the risk of several diseases such as cardiovascular diseases (CVD), diabetes, and hypertension. These ailments are associated with declined cognitive function.Objective: We aimed to examine the association between serum magnesium and cognitive function among Qatari adults. In addition, we assessed the interaction relation between low serum magnesium, hypertension, and diabetes in relation to cognitive function.Method: Data from 1,000 Qatari participants aged ≥20 years old who participated in the Qatar Biobank (QBB) Study were analyzed. Serum magnesium was measured by an automated calorimetric method and suboptimal magnesium was characterized by <0.85 mmol/l. Cognitive function was determined by measuring the mean reaction time (MRT) based on a computer-based, self-administered test. Multivariable linear regression was used to examine the relation between serum magnesium concentrations and cognitive function.Results: The prevalence of suboptimal magnesium was 57.1%. Across the four quartiles of serum magnesium from the lowest to the highest, the regression coefficients (95% CI) for MRT were 0 (reference), −17.8, −18.3, and −31.9 (95% CI 2.4-3.1; p for trend 0.05). The presence of hypertension and diabetes significantly increased the MRT. Women with suboptimal magnesium and hypertension had the highest MRT. Conclusion:The prevalence of suboptimal magnesium is high in Qatar. There was a direct association between serum magnesium and cognitive function. Low magnesium concentrations were associated with a longer MRT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali

Eltayeb

Musleh

et al. 2020

Front. Aging Neurosci.

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“…Ang II is a critical factor in hypertension, diabetes, and aging, and it induces many metabolic pathway disorders. Hypertension and diabetes are considered to be the main components of metabolic syndrome, sharing a common pathogenesis according to a large number of basic and clinical studies (38)(39)(40). About 60-70% of diabetic patients have hypertension (41), and hypertensive patients have abnormal glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

UPLC-MS-Based Serum Metabolomics Reveals Potential Biomarkers of Ang II-Induced Hypertension in Mice

Yang

Wang

Guo

et al. 2021

Front. Cardiovasc. Med.

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Hypertension is caused by polygenic inheritance and the interaction of various environmental factors. Abnormal function of the renin-angiotensin-aldosterone system (RAAS) is closely associated with changes in blood pressure. As an essential factor in the RAAS, angiotensin II (Ang II) contributes to vasoconstriction and inflammatory responses. However, the effects of overproduction of Ang II on the whole body-metabolism have been unclear. In this study, we established a hypertensive mouse model by micro-osmotic pump perfusion of Ang II, and the maximum systolic blood pressure reached 140 mmHg after 2 weeks. By ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, the metabolites in the serum of hypertensive model and control mice were analyzed. Partial least squares discriminant analysis (PLS-DA) in both positive and negative ionization modes showed clear separation of the two groups. Perfusion of Ang II induced perturbations of multiple metabolic pathways in mice, such as steroid hormone biosynthesis and galactose metabolism. Tandem mass spectrometry revealed 40 metabolite markers with potential diagnostic value for hypertension. Our data indicate that non-targeted metabolomics can reveal biochemical pathways associated with Ang II-induced hypertension. Although researches about the clinical use of these metabolites as potential biomarkers in hypertension is still needed, the current study improves the understanding of systemic metabolic response to sustained release of Ang II in hypertensive mice, providing a new panel of biomarkers that may be used to predict blood pressure fluctuations in the early stages of hypertension.

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“…Shi et al [8] noted that subclinical magnesium deficiency, defined as serum magnesium under 0.85 mmol/L (2.06 mg/dL), was common in Qatar and associated with diabetes, prediabetes, and hypertension in Qatari adults. So the hypomagnesemia of our patient may be a consequence of her type 1 diabetes, or just the result of inappropriate food magnesium intake.…”

Section: Fig 1 Pneumonia Of the Left Lower Lobe Chest X-raymentioning

confidence: 99%

COVID-19 Pneumonia, Diabetes and Alteration of the Biochemical Values of Blood: A Case Report and Review of the Literature

Vicoveanu¹,

Covali²,

Riscanu³

et al. 2021

JAMMR

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Aims: The variability in evolution of the novel coronavirus has perplexed the medical community. We herein report the case of a patient with specific characteristics, somewhat outside the reported average values. Presentation of Case: A 60-year-old type I diabetic patient was admitted as an outpatient to a university hospital for the following symptoms: fever up to 38.1˚C, malaise, and shortness of breath. Upon admittance, the chest X-ray revealed a homogenous triangular opacity, of medium intensity, located in the lower lobe of the left lung, suggesting pneumonia. Altered biochemistry values in our hospital included ALT = 86U/L, AST = 118 U/L, serum urea = 43.4 mg/dL, serum creatinine = 1.43 mg/dL, fasting blood glucose = 167.9 mg/dL (she had type 1 diabetes and received insulin only in the evening), triglycerides = 214.9 mg/dL, serum magnesium = 1.48 mg/dL, serum iron = 14.1 mg/dL. Fever, malaise, and shortness of breath, together with the X-ray image of the chest suggested COVID-19. RT-PCR confirmed the diagnosis 12 hours later. Three days after admission, she felt dyspneic, and oxygen therapy was administered for 7 days, together with Lopinavir/Ritonavir, Dexamethasone, Heparin and Vitamin C. After 18 days in the hospital, she felt good, and was released from the hospital. Conclusion: Despite the numerous aggravating factors for COVID-19 (age [60 years old], type 1 diabetes, increased values of ALT, AST, serum urea, serum creatinine, fasting blood glucose, low serum magnesium, one whole lobe pneumonia, and only one favorable factor–low serum iron), the patient survived and recovered.

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Association of low serum magnesium with diabetes and hypertension: Findings from Qatar Biobank study

Cited by 15 publications

References 30 publications

Serum Magnesium and Cognitive Function Among Qatari Adults

Serum Magnesium and Cognitive Function Among Qatari Adults

UPLC-MS-Based Serum Metabolomics Reveals Potential Biomarkers of Ang II-Induced Hypertension in Mice

COVID-19 Pneumonia, Diabetes and Alteration of the Biochemical Values of Blood: A Case Report and Review of the Literature

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