Association of Longitudinal Mammographic Breast Density Changes with                     Subsequent Breast Cancer Risk

Tran, Thi Xuan Mai; Kim, Soyeoun; Song, Huiyeon; Lee, Eun Hye; Park, Boyoung

doi:10.1148/radiol.220291

Cited by 12 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, to our knowledge, there are limited data on the association between change in density over time and risk of subsequent breast cancer diagnosis. Retrospective data from Korea show that change in the category of Breast Imaging Reporting and Data System (BI-RADS) breast density is associated with change in risk across 3 mammograms, consistent with an earlier meta-analysis . However, this study did not use volumetric analysis of density.…”

Section: Introductionsupporting

confidence: 84%

“…Although density is an accepted intermediate marker of breast cancer risk, studies of change in density are limited. Previous studies have used reader-dependent, subjective measures of density and categorical density data (fatty, scattered, heterogeneously dense, and extremely dense in accordance with BI-RADS) . Previous studies have also been based on analysis of digitized radiographic images, which are of lower image quality than standard digital mammograms .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk

et al. 2023

View full text Add to dashboard Cite

ImportanceAlthough breast density is an established risk factor for breast cancer, longitudinal changes in breast density have not been extensively studied to determine whether this factor is associated with breast cancer risk.ObjectiveTo prospectively evaluate the association between change in mammographic density in each breast over time and risk of subsequent breast cancer.Design, Setting, and ParticipantsThis nested case-control cohort study was sampled from the Joanne Knight Breast Health Cohort of 10 481 women free from cancer at entry and observed from November 3, 2008, to October 31, 2020, with routine screening mammograms every 1 to 2 years, providing a measure of breast density. Breast cancer screening was provided for a diverse population of women in the St Louis region. A total of 289 case patients with pathology-confirmed breast cancer were identified, and approximately 2 control participants were sampled for each case according to age at entry and year of enrollment, yielding 658 controls with a total number of 8710 craniocaudal-view mammograms for analysis.ExposuresExposures included screening mammograms with volumetric percentage of density, change in volumetric breast density over time, and breast biopsy pathology-confirmed cancer. Breast cancer risk factors were collected via questionnaire at enrollment.Main Outcomes and MeasuresLongitudinal changes over time in each woman’s volumetric breast density by case and control status.ResultsThe mean (SD) age of the 947 participants was 56.67 (8.71) years at entry; 141 were Black (14.9%), 763 were White (80.6%), 20 were of other race or ethnicity (2.1%), and 23 did not report this information (2.4%). The mean (SD) interval was 2.0 (1.5) years from last mammogram to date of subsequent breast cancer diagnosis (10th percentile, 1.0 year; 90th percentile, 3.9 years). Breast density decreased over time in both cases and controls. However, there was a significantly slower decrease in rate of decline in density in the breast that developed breast cancer compared with the decline in controls (estimate = 0.027; 95% CI, 0.001-0.053; P = .04).Conclusions and RelevanceThis study found that the rate of change in breast density was associated with the risk of subsequent breast cancer. Incorporation of longitudinal changes into existing models could optimize risk stratification and guide more personalized risk management.

show abstract

Section: Introductionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Longitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk

et al. 2023

View full text Add to dashboard Cite

show abstract

“…38,39 Changes in breast density might affect breast cancer risk over time. 14,37 For women with FHBC, a decrease in mass from dense breasts to fatty or scattered fibroglandular breasts through breastfeeding and primary prevention with tamoxifen citrate [25][26][27] would help reduce their breast cancer risk. These primary preventions might be helpful for women with dense breasts in terms of reducing their breast density and subsequently decreasing their risk of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Mammographic breast density decreases with increasing age and is affected by other factors, including parity, hormone use, and involution . Changes in breast density might affect breast cancer risk over time . For women with FHBC, a decrease in mass from dense breasts to fatty or scattered fibroglandular breasts through breastfeeding and primary prevention with tamoxifen citrate would help reduce their breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

“…11 In addition, breast density decreases with increasing age. 12 However, recent studies 13,14 have suggested that increased breast density over time is associated with a higher risk of breast cancer, whereas decreased breast density is associated with a reduced risk of breast cancer. Thus, we hypothesized that premenopausal women with FHBC have a high likelihood of having dense breasts and increased breast density over time or having persistently dense breasts.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Breast Cancer Family History With Breast Density Over Time in Korean Women

et al. 2023

Self Cite

View full text Add to dashboard Cite

ImportanceEvidence suggests that women with a family history of breast cancer (FHBC) in first-degree relatives have a higher level of breast density; however, studies of premenopausal women remain limited.ObjectiveTo investigate the association between FHBC and mammographic breast density and breast density changes among premenopausal women.Design, Setting, and ParticipantsThis retrospective cohort study used population-based data obtained from the National Health Insurance Service–National Health Information Database of Korea. We included premenopausal women aged 40 to 55 years who underwent mammography for breast cancer screening once between January 1, 2015, and December 31, 2016 (n = 1 174 214), and women who underwent mammography twice (first in 2015-2016 and again between January 1, 2017 and December 31, 2018) (n = 838 855).ExposuresFamily history of breast cancer was assessed using a self-reported questionnaire, which included information on FHBC in the mother and/or sister.Main Outcomes and MeasuresBreast density, based on the Breast Imaging Reporting and Data System, was categorized as dense (heterogeneously or extremely dense) and nondense (almost entirely fat or scattered fibroglandular areas). Multivariate logistic regression was used to assess the association among FHBC, breast density, and changes in breast density from the first to second screening. Data analysis was performed from June 1 to September 31, 2022.ResultsOf the 1 174 214 premenopausal women, 34 003 (2.4%; mean [SD] age, 46.3 [3.2] years) reported having FHBC among their first-degree relatives, and 1 140 211 (97.1%; mean [SD] age, 46.3 [3.2] years) reported no FHBC. Odds of having dense breasts was 22% higher (adjusted odds ratio [aOR], 1.22; 95% CI, 1.19-1.26) in women with FHBC than in women without FHBC, and the association varied by affected relatives: mother alone (aOR, 1.15; 95% CI, 1.10-1.21), sister alone (aOR, 1.26; 95% CI, 1.22-1.31), and both mother and sister (aOR, 1.64; 95% CI, 1.20-2.25). Among women with fatty breasts at baseline, the odds of developing dense breasts was higher in women with FHBC than in those without FHBC (aOR, 1.19; 95% CI, 1.11-1.26), whereas among women with dense breasts, higher odds of having persistently dense breasts were observed in women with FHBC (aOR, 1.11; 95% CI, 1.05-1.16) than in those without FHBC.Conclusions and RelevanceIn this cohort study of premenopausal Korean women, FHBC was positively associated with an increased incidence of having increased or persistently dense breasts over time. These findings suggest the need for a tailored breast cancer risk assessment for women with FHBC.

show abstract

Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening

Gastounioti

Cohen

Pantalone

et al. 2023

Breast Cancer Res Treat

View full text Add to dashboard Cite

Association of Longitudinal Mammographic Breast Density Changes with Subsequent Breast Cancer Risk

Cited by 12 publications

References 39 publications

Longitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk

Longitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk

Association of Breast Cancer Family History With Breast Density Over Time in Korean Women

Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening

Contact Info

Product

Resources

About