Association of Long-term Ambient Fine Particulate Matter (PM2.5) and Incident CKD: A Prospective Cohort Study in China

Duan, Jingwen; Li, Yalan; Li, Shenxin; Yang, Yiping; Li, Fēi; Li, Yan; Wang, Jie; Deng, Peizhi; Wu, Jingjing; Wang, Wei; Meng, Changjiang; Miao, Rujia; Chen, Zhiheng; Zou, Bin; Yuan, Hong; Cai, Jingjing; Lu, Yao

doi:10.1053/j.ajkd.2022.03.009

Cited by 24 publications

(15 citation statements)

References 33 publications

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“…In this study, The association between PM 2.5 and CKD was even stronger in cohort studies, with risk estimates almost doubling. This result was consistent with Duan et al [3] study, which showed that people who were exposed to PM 2.5 over the long term had a higher risk of CKD than those who were exposed for a short period. The average PM 2.5 concentration in the previous year and the cumulative average PM 2.5 concentration increased the risk of CKD by 1.28 times and 1.71 times, respectively.…”

Section: Principal Findingssupporting

confidence: 92%

“…Seventeen studies used a cohort design [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and 16 studies used a cross-sectional design, [4,16,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] one of which used two study designs, [4] including 10.53 million people worldwide (Table 1).…”

Section: Literature Retrieval and Study Characteristicsmentioning

confidence: 99%

“…17 cohort studies [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and 15 cross-sectional studies [4,16,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] were considered to be of 'high quality' according to the NOS and JBI scales. One cross-sectional study was deemed of 'moderate quality'.…”

Section: Study Quality and Risk Of Biasmentioning

confidence: 99%

“…CKD was positively correlated with all air pollutants except for O 3 (O 3 : OR = 0.97, 95% confidence interval [CI] = 0.87-1.08; I 2 = 54.3%) (Figure 2). [12,17,26,[30][31][32] Long-term exposure to PM 2.5 , [3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][25][26][27][28][29][30][31]33,34] PM 10 , [5,[13][14][15][16][17][18][19]21,22,[24][25][26][27]31,33]…”

Section: Long-term Air Pollution Exposure and Ckdmentioning

confidence: 99%

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Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

Xu,

Jia,

Lin

et al. 2023

J Biochem & Molecular Tox

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Although epidemiological studies have evaluated the association between ambient air pollution and chronic kidney disease (CKD), the results remain mixed. To clarify the nature of the association, we conducted a comprehensive systematic review and meta‐analysis to assess the global relationship between air pollution and CKD. The Web of Science, PubMed, Embase and Cochrane Library databases systematically were searched for studies published up to July 2023 and included 32 studies that met specific criteria. The random effects model was used to derive overall risk estimates for each pollutant. The meta‐analysis estimated odds ratio (ORs) of risk for CKD were 1.42 (95% confidence interval [CI]: 1.31–1.54) for each 10 μg/m3 increase in PM2.5; 1.20 (95% CI: 1.14–1.26) for each 10 μg/m3 increase in PM10; 1.07 (95% CI: 1.05–1.09) for each 10 μg/m3 increase in NO2; 1.03 (95% CI: 1.02–1.03) for each 10 μg/m3 increase in NOX; 1.07 (95% CI: 1.01–1.12) for each 1 ppb increase in SO2; 1.03 (95% CI: 1.00–1.05) for each 0.1 ppm increase in CO. Subgroup analysis showed that this effect varied by gender ratio, age, study design, exposure assessment method, and income level. Furthermore, PM2.5, PM10, and NO2 had negative effects on CKD even within the World Health Organization‐recommended acceptable concentrations. Our results further confirmed the adverse effect of air pollution on the risk of CKD. These findings can contribute to enhance the awareness of the importance of reducing air pollution among public health officials and policymakers.

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Section: Principal Findingssupporting

confidence: 92%

Section: Literature Retrieval and Study Characteristicsmentioning

confidence: 99%

Section: Study Quality and Risk Of Biasmentioning

confidence: 99%

Section: Long-term Air Pollution Exposure and Ckdmentioning

confidence: 99%

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Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

Xu,

Jia,

Lin

et al. 2023

J Biochem & Molecular Tox

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“…They enter the lung through the respiratory system and act on other human body organs. The results of a prospective study spanning 2005 to 2018 and covering 121 counties in Hunan, China, showed a strong positive correlation between high-level PM2.5 exposure and chronic kidney disease ( Duan et al, 2022 ). Animal studies have shown that the kidney is a toxicological target of particulate pollutants inhaled from the lungs ( Nemmar et al, 2010 ).…”

Section: Composition and Mechanism Of Particulate Matter 25mentioning

confidence: 99%

MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

Zhou

Dai²,

Jiang³

et al. 2022

Front. Pharmacol.

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Primary membranous nephropathy (PMN), is an autoimmune glomerular disease and the main reason of nephrotic syndrome in adults. Studies have confirmed that the incidence of PMN increases yearly and is related to fine air pollutants particulate matter 2.5 (PM2.5) exposure. These imply that PM2.5 may be associated with exposure to PMN-specific autoantigens, such as the M-type receptor for secretory phospholipase A2 (PLA2R1). Emerging evidence indicates that Th17/Treg turns to imbalance under PM2.5 exposure, but the molecular mechanism of this process in PMN has not been elucidated. As an important indicator of immune activity in multiple diseases, Th17/Treg immune balance is sensitive to antigens and cellular microenvironment changes. These immune pathways play an essential role in the disease progression of PMN. Also, microRNAs (miRNAs) are susceptible to external environmental stimulation and play link role between the environment and immunity. The contribution of PM2.5 to PMN may induce Th17/Treg imbalance through miRNAs and then produce epigenetic affection. We summarize the pathways by which PM2.5 interferes with Th17/Treg immune balance and attempt to explore the intermediary roles of miRNAs, with a particular focus on the changes in PMN. Meanwhile, the mechanism of PM2.5 promoting PLA2R1 exposure is discussed. This review aims to clarify the potential mechanism of PM2.5 on the pathogenesis and progression of PMN and provide new insights for the prevention and treatment of the disease.

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Long-term exposure to fine particulate matter constituents in relation to chronic kidney disease: evidence from a large population-based study in China

Dai,

Yin,

et al. 2024

Environ Geochem Health

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Association of Long-term Ambient Fine Particulate Matter (PM2.5) and Incident CKD: A Prospective Cohort Study in China

Cited by 24 publications

References 33 publications

Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy

Long-term exposure to fine particulate matter constituents in relation to chronic kidney disease: evidence from a large population-based study in China

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