Association of long noncoding RNA and c-JUN expression in hepatocellular carcinoma

Abstract

This information sheds light on the possible role of lncRNA-UCA1 and C-JUN mRNA as promising diagnostic and prognostic markers as well as potential therapeutic targets in HCC.

Diagnostic value of long noncoding RNAs for hepatocellular carcinoma

“…As reported, lncRNAs could discriminate patients with HCC from healthy people with higher accuracy than the existing biomarkers (sensitivity: 91.4% vs 82.8%; specificity: 88.6% vs 82.8%), when combined with AFP, the sensitivity significant raises to 100%. [28] Likewise, a panel of lncRNAs (lncRNA-UCA1 and lncRNA-WRAP53) also achieved a higher accuracy than single lncRNA. [31] However, in contrast to these studies, [30,31,42] the difference in overall sensitivity and specificity was not statistical significant between panels of lncRNAs and single lncRNA in our study.…”

Performance of different biomarkers for the management of hepatocellular carcinoma

“…The results showed that AUC for plasma DANCR was 0.868 which was higher than that for AFP (AUC = 0.744) when differentiating patients with HCC from non-HCC patients [112] . Besides these circulating lncRNAs, JPX, UCA1 and WRAP53 were found increased in HCC patients [106,113,114] alone or in combination with other lncRNAs, miRNAs or serum biomarkers [115] . Many reports have indicated that the deregulation of lncRNAs plays important roles in occurrence and progression of HCC however further studies are needed in order to use these as biomarkers.…”

Competing Endogenous RNAs in Hepatocellular Carcinoma—The Pinnacle of Rivalry

“…For example, lncRNA UCA1 can be used to detect HCC with a sensitivity of 91.4% and a specificity of 88.6%. 95 miR-375 levels can also be used to differentiate between healthy individuals and HBV-associated HCC with 96% sensitivity and 100% specificity. 96 Recently, ceRNA networks have been identified in pancreatic cancer and lung adenocarcinoma with the intention of using them as potential biomarkers for diagnosis.…”