Association of local immune suppression in skin with HPV-induced epithelial hyperplasia

Abstract

Persisting high-risk human papillomavirus (HPV) infection is a major cause of cervical cancer, which develops from cervical intraepithelial neoplasia (CIN). "High-risk" HPVs, in particular HPV16 and HPV18, are able to evade immunosurveillance in some patients, and create a suppressive local immune environment. Expression of viral protein E7 causes a dysregulated cell cycle, a result of E7 and Rb protein interaction, leading to epithelial x Financial support The candidate was supported by