Association of lipid profile parameters, atherogenic index of plasma, anthropometric parameters with the severity of the COVID-19 course in Novosibirsk women

Abstract

Background: Our study aimed to assess the relationship between the parameters of the lipid profile, atherogenic index of plasma (AIP), anthropometry influence with the severity of the new coronavirus infection COVID-19 in women. Material and methods. The study design was a cross-sectional study. The research included 138 women aged 29–82 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 61), moderate (n = 70) and severe (n = 7). Body mass index, waistline and hip circumference, waistline circumference to hip circumference index, total cholesterol, triglycerides, HDL, LDL, AIP were calculated. Statistical processing of the obtained results was carried out using the SPSS software package (version 20.0) using the Mann-Whitney test, univariate logistic regression analysis, Pearson chi-squared test. Results. The levels of HDL-cholesterol were significantly lower in group 3 compared with the level of HDL-cholesterol in women in group 2 (p2-3 = 0.046). BMI was higher in the moderately severe group compared to the mild one (26.32 [23.305; 30.4] versus 28.78 [24.72; 34.77], p1-2 = 0.026). Hip circumference was higher in patients with severe COVID-19 than in patients with mild course (104 [98; 112] versus 114 [109.5; 126], p1-3 = 0.039), AIP was higher in women with severe course compared to women with moderate and mild course (p1-3 = 0.043, p2-3 = 0.04). The results of the logistic regression analysis showed that the moderate course of COVID-19 is associated with BMI (OR = 1.09, 95 % CI 1.019–1.166, p1-2 = 0.012), and the severe course with WC (OR = 1.041, 95 % CI 1.001–1.084, p1-3 = 0.046), AIP value ≥ 0.11 (OR = 13.824, 95 % CI 1.505–126.964, p1-3 = 0.02; OR = 11,579, 95 % CI 1,266–105,219, p2-3 = 0.03) and HDL level < 40 mg/dl (OR = 14,750, 95 % CI 2,317–93,906, p1-3 = 0.004; OR = 8,000, 95 % CI 1,313– 48,538, p1-3 = 0.024). Conclusion. Patients from the group with moderate and severe course of the new coronavirus infection have higher body mass index, hip circumference, AIP, lower HDL values. The chance of a moderate course of COVID-19 is associated with an increased BMI value, and a severe course with WC, AIP ≥ 0.11 and HDL level < 40 mg/dl.

Comment on “The atherogenic index of plasma as a predictor of mortality in patients with COVID-19.”

“…Finally, a research logistic regression analysis showed that a moderate course of COVID-19 among Novosibirsk women is associated with BMI (odds ratio (OR) = 1.090, 95% confidence interval (95% CI) 1.019–1.166, p = 0.012), and a severe course is associated with WC (OR = 1.041, 95% CI 1.001–1.084, p = 0.046), AIP ≥ 0.11 (compared to both mild (OR = 13.824, 95% CI 1.505–126.964, p = 0.02) and moderate (OR = 11.579). 3 …”

Letter to the Editor: The atherogenic index of plasma as a predictor of mortality in patients with COVID-19

“…As a result, a research's logistic regression analysis showed that a moderate course of COVID-19 among Novosibirsk women is associated with BMI (odds ratio (OR) = 1.090, 95% confidence interval (95% CI) 1.019-1.166, p = 0.012), and a severe course is associated with WC (OR = 1.041, 95% CI 1.001-1.084, p = 0.046), compared to both mild (OR = 13.824, 95% CI 1.505-126.964, p = 0.02) and moderate (OR = 11.579). [3] In addition, when calculating AIP, the unit of both triglyceride (TG) and high-density lipoprotein (HDL) levels should be mmol. However, the author used mg/dl units when calculating the AIP value.…”