Association of lipid lowering drugs and the risk of systemic lupus erythematosus: a drug target Mendelian randomization
Tong Wu,
Ling Ye,
Shenglan Wang
et al.
Abstract:Background and objective: An interaction between low-density lipoprotein level, lipid-lowering drugs, and systemic lupus erythematosus (SLE) was reported by previous studies. However, whether lipid-lowering drugs provided protective effect for reducing the risk of SLE was unclear. We aimed to clarify this causal relationship through a drug-target Mendelian randomization (MR) study.Methods: Genetic instruments—single nucleotide polymorphism (SNPs)—were utilized to proxy inhibition of the three genes—3-hydroxy-3… Show more
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