Association of LIPC and advanced age-related macular degeneration

Lee, Jongdae; Zeng, Junjie; Hughes, Guy; Chen, Y; Grob, Seanna; Zhao, Ling; Lee, C; Krupa, Martin; Quach, John; Luo, Jing; Wei, Xingmei; Zhang, X; Duan, Yaou; Ferreyra, Henry; Goldbaum, Michael H.; Haw, Weldon W; Shaw, Peter X.; Tang, Lanhua; Zhang, K

doi:10.1038/eye.2012.276

Cited by 17 publications

(22 citation statements)

References 37 publications

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“…As described earlier, oxidized lipid and cholesterol metabolites have been found to induce the age-related changes in AMD resulting in apoptosis of RPE cells . Based on the previous genetic studies [Thuren, 2000;Chen et al, 2010;Lee et al, 2013;Wang et al, 2015], we explored the levels of hepatic lipase (HL) in AMD and found high levels of HL in AMD patients in comparison to controls. This signifies that the lipid metabolism and its association with AMD pathological is quite significant.…”

Section: Discussionmentioning

confidence: 99%

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Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases

et al. 2017

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AMD is a complex eye disease predominantly occurring in aged population. Till now about 53 genetic loci have been found to be associated with the AMD pathology. AMD pathogenesis is being increasingly known to progress through mechanisms independent of the CFH mediated pathway. Therefore, our aim for current study was to examine the genes by analyzing their expression levels in AMD. We recruited about 50 AMD and same number of age matched controls. We analyzed the CFH duplication and deletion by multiplex ligation probe amplification (MLPA) and found no duplication and deletion in CFH gene in AMD patients. We also estimated the IER-3, SLC16A8, LIPC, and TIMP-3 expression levels in both CFH-negative AMD cases (i.e. no duplication and deletion in CFH gene) besides examining these in AMD and controls. We found that the expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with AMD pathology in both groups (LIPC: P = 0.008, SLC16A8: P < 0.001, TIMP-3: P < 0.001, respectively). However, we did not find any significant difference in IER-3 levels in AMD and controls. Therefore, the evidence from current study, suggests that AMD pathology may be mediated through mechanistic pathways linked to other genetic loci. J. Cell. Biochem. 118: 2087-2095, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…HL genetic variant rs10468017 has found to be significantly associated with the progression of AMD pathology ( P < 0.001) [Wang et al, ]. Similarly, Lee et al performed cohort study on 1626 advanced AMD participants and demonstrated two genetic variants rs493258 and rs10468017 significantly correlated with the advanced AMD pathology [Lee et al, ].…”

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confidence: 99%

Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases

et al. 2017

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“…Interestingly, a gene (LIPC) with a known, but not completely understood, [38][39][40][41] association with AMD was upregulated in SCAC iPSC-3-RPE.…”

Section: Rpe Generation Compared Between Scac and Directed Differentimentioning

confidence: 99%

Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods

Leach

Croze

et al. 2016

Journal of Ocular Pharmacology and Therapeutics

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Purpose: The application of induced pluripotent stem cell-derived retinal pigmented epithelium (iPSC-RPE) in patients with retinal degenerative disease is making headway toward the clinic, with clinical trials already underway. Multiple groups have developed methods for RPE differentiation from pluripotent cells, but previous studies have shown variability in iPSC propensity to differentiate into RPE. Methods: This study provides a comparison between 2 different methods for RPE differentiation: (1) a commonly used spontaneous continuously adherent culture (SCAC) protocol and (2) a more rapid, directed differentiation using growth factors. Integration-free iPSC lines were differentiated to RPE, which were characterized with respect to global gene expression, expression of RPE markers, and cellular function. Results: We found that all 5 iPSC lines (iPSC-1, iPSC-2, iPSC-3, iPSC-4, and iPSC-12) generated RPE using the directed differentiation protocol; however, 2 of the 5 iPSC lines (iPSC-4 and iPSC-12) did not yield RPE using the SCAC method. Both methods can yield bona fide RPE that expresses signature RPE genes and carry out RPE functions, and are similar, but not identical to fetal RPE. No differences between methods were detected in transcript levels, protein localization, or functional analyses between iPSC-1-RPE, iPSC-2-RPE, and iPSC-3-RPE. Directed iPSC-3-RPE showed enhanced transcript levels of RPE65 compared to directed iPSC-2-RPE and increased BEST1 expression and pigment epithelium-derived factor (PEDF) secretion compared to directed iPSC-1-RPE. In addition, SCAC iPSC-3-RPE secreted more PEDF than SCAC iPSC-1-RPE. Conclusions: The directed protocol is a more reliable method for differentiating RPE from various pluripotent sources and some iPSC lines are more amenable to RPE differentiation.

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“…The full text article of the remaining 35 studies was obtained and evaluated according to the eligibility criteria. Finally, seven articles including 17 studies meeting the predetermined inclusion criteria were used for meta-analysis [8,9,14,15,16,17,18]. …”

Section: Resultsmentioning

confidence: 99%

The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration

Wang

Zhang

et al. 2016

IJERPH

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The purpose of this study was to evaluate the association of the hepatic lipase (LIPC) rs493258 polymorphism and susceptibility to age-related macular degeneration (AMD). A systematic search in PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to April 2016. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) in different stages of AMD were estimated under different genetic models using meta-analytic methods. Seven studies comprising 20,559 cases and 17,200 controls met the inclusion criteria and were included in the meta-analysis. The LIPC rs493258 polymorphism showed a significant association with a lower risk of AMD under the allelic model (OR = 0.87, 95% CI = 0.84–0.90). Significant relationships between the variant and AMD were also observed in other genetic models (OR ranging from 0.71 to 0.86, all p < 0.05). Stratified analysis based on ethnicity found that LIPC rs493258 polymorphism had a significant association with the decreased risk of the disease in the Caucasian population, but not in the Asian population. For late AMD, significant associations of the rs493258 polymorphism with a lower risk of this disease were also observed in the allelic genetic model (OR = 0.87, 95% CI = 0.83–0.90). This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late AMD. The associations of the locus with early and late AMD risk in various populations need further exploration.

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Association of LIPC and advanced age-related macular degeneration

Cited by 17 publications

References 37 publications

Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases

Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases

Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods

The Association between LIPC rs493258 Polymorphism and the Susceptibility to Age-Related Macular Degeneration

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