Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review

Bürger, Zoé; Bucher, Anna Magdalena; Comasco, Erika; Henes, Melanie; Hübner, Stephanie; Kogler, Lydia; Derntl, Birgit

doi:10.1016/j.yfrne.2021.100943

Cited by 16 publications

(8 citation statements)

References 79 publications

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“…This includes levonorg estrelintrauterinedevices, although they are one of the most used contraceptive methods worldwide. Our findings align with a recent ly published study by Bürger et al (2021) [83], who could not find these studies either. The lack of MRI studies investigating the effect of intrauterine devices on the brain might be their incompatibility with MRI scanners.…”

Section: The Role Of 'The Pill'supporting

confidence: 92%

‘That Time of the Month’ – Investigating the Influence of the Menstrual Cycle and Oral Contraceptives on the Brain Using Magnetic Resonance Imaging

Schuster

Jansen

2022

Exp Clin Endocrinol Diabetes

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The stereotypic and oversimplified relationship between female sex hormones and undesirable behavior dates to the earliest days of human society, as already the ancient Greek word for the uterus, “hystera” indicated an aversive connection. Remaining and evolving throughout the centuries, transcending across cultures and various aspects of everyday life, its perception was only recently reframed. Contemporarily, the complex interaction of hormonal phases (i. e., the menstrual cycle), hormonal medication (i. e., oral contraceptives), women’s psychological well-being, and behavior is the subject of multifaceted and more reflected discussions. A driving force of this ongoing paradigm shift was the introduction of this highly interesting and important topic into the realm of scientific research. This refers to neuroscientific research as it enables a multimodal approach combining aspects of physiology, medicine, and psychology. Here a growing body of literature points towards significant alterations of both brain function, such as lateralization of cognitive functions, and structure, such as gray matter concentrations, due to fluctuations and changes in hormonal levels. This especially concerns female sex hormones. However, the more research is conducted within this field, the less reliable these observations and derived insights appear. This may be due to two particular factors: measurement inconsistencies and diverse hormonal phases accompanied by interindividual differences. The first factor refers to the prominent unreliability of one of the primarily utilized neuroscientific research instruments: functional magnetic resonance imaging (fMRI). This unreliability is seemingly present in paradigms and analyses, and their interplay, and is additionally affected by the second factor. In more detail, hormonal phases and levels further influence neuroscientific results obtained through fMRI as outcomes vary drastically across different cycle phases and medication. This resulting vast uncertainty thus tremendously hinders the further advancement of our understanding of how female sex hormones might alter brain structure and function and, ultimately, behavior.This review summarizes parts of the current state of research and outlines the essential requirements to further investigate and understand the female brain’s underlying physiological and anatomical features.

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Section: The Role Of 'The Pill'supporting

confidence: 92%

‘That Time of the Month’ – Investigating the Influence of the Menstrual Cycle and Oral Contraceptives on the Brain Using Magnetic Resonance Imaging

Schuster

Jansen

2022

Exp Clin Endocrinol Diabetes

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“…In a recent review, the authors have revealed that hormonal IUD has no effects on mental health and sexual functioning. Future larger studies are needed for women vulnerable to adverse effects of hormonal IUDs (57).…”

Section: Pelvic Inflammatory Disease (Pid)mentioning

confidence: 99%

Intrauterin Devices: What Has Changed?

Uysal¹

2022

JEURMEDS

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Intra-uterine devices (IUDs) are one of the most common, long acting, reversibly-used methods of contraception in the world. IUDs are safe and effective T shaped designed plastic framed devices including copper or levonorgestrel. The purpose of this review was to outline the types, mechanisms, benefits, and adverse effects of IUDs and to help for selection of candidates and devices. The most important role in the mechanism of action is to cause sterile inflammation in the uterine cavity. Hormonal IUDs have also non-contraceptive benefits like reduction in heavy menstrual bleeding, dysmenorrhea, pelvic pain, endometrial hyperplasia and anemia. Pelvic inflammatory disease (PID), ectopic pregnancy, anemia and progestin related complaints including acne, weight change, headache, mood changes, hirsutism and nausea are some undesirable effects of IUDs. IUDs are highly preferred in the world and will not be abandoned in the future. They are easily accessible, cheap and cost-effective for contraception.

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“…Table summarizes the detailed characteristic features of each contraceptive method, including the contraceptive mechanism, pearl index, materials, effective duration, and clinical concerns. These approaches achieve contraceptive effectiveness by inhibiting ovulation, thickening cervical mucus to reduce sperm migration, deactivating sperm, and causing an inflammatory reaction in the uterus. − The effectiveness of existing clinical contraceptives can be ranked by their ability to reduce the chance of unintended pregnancy, calculated by the pearl index . However, there are still a lot of concerns about these clinical contraceptives, such as the hormonal side effects and progestogen-like symptoms of hormonal drugs, the inflammatory response and tissue damage of Cu-IUD, the allergic symptoms of the barrier, and the pain and infection of surgery.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects

Su,

Diao,

McGuire

et al. 2023

ACS Nano

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Preventing unintentional pregnancy is one of the goals of a global public health policy to minimize effects on individuals, families, and society. Various contraceptive formulations with high effectiveness and acceptance, including intrauterine devices, hormonal patches for females, and condoms and vasectomy for males, have been developed and adopted over the last decades. However, distinct breakthroughs of contraceptive techniques have not yet been achieved, while the associated long-term adverse effects are insurmountable, such as endocrine system disorder along with hormone administration, invasive ligation, and slowly restored fertility after removal of intrauterine devices. Spurred by developments of nanomaterials and bionanotechnologies, advanced contraceptives could be fulfilled via nanomaterial solutions with much safer and more controllable and effective approaches to meet various and specific needs for women and men at different reproductive stages. Nanomedicine techniques have been extended to develop contraceptive methods, such as the targeted drug delivery and controlled release of hormone using nanocarriers for females and physical stimulation assisted vasectomy using functional nanomaterials via photothermal treatment or magnetic hyperthermia for males. Nanomaterial solutions for advanced contraceptives offer significantly improved biosafety, noninvasive administration, and controllable reversibility. This review summarizes the nanomaterial solutions to female and male contraceptives including the working mechanisms, clinical concerns, and their merits and demerits. This work also reviewed the nanomaterials that have been adopted in contraceptive applications. In addition, we further discuss safety considerations and future perspectives of nanomaterials in nanostrategy development for next-generation contraceptives. We expect that nanomaterials would potentially replace conventional materials for contraception in the near future.

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Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review

Cited by 16 publications

References 79 publications

‘That Time of the Month’ – Investigating the Influence of the Menstrual Cycle and Oral Contraceptives on the Brain Using Magnetic Resonance Imaging

‘That Time of the Month’ – Investigating the Influence of the Menstrual Cycle and Oral Contraceptives on the Brain Using Magnetic Resonance Imaging

Intrauterin Devices: What Has Changed?

Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects

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