Association of Leptin in Periodontitis and Acute Myocardial Infarction

Gundala, Rupasree; Chava, Vijay Kumar; Ramalingam, K.

doi:10.1902/jop.2012.110620

Cited by 25 publications

(26 citation statements)

References 29 publications

(38 reference statements)

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“…Furthermore, leptin has contrasting effects on bone metabolism: an indirect, suppressive effect through the hypothalamus 29 or direct stimulation of osteoblast proliferation and differentiation and by prolonging the lifespan of primary osteoblasts 30 . Plasma/serum leptin concentrations increase during many inflammatory diseases including CP and cardiovascular disease 15‐20 . In the present study, the patients with CP had increased serum leptin concentrations, on average up to 11,600 pg/mL, which is in accordance with previous studies 15,16 .…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, in serum/plasma, leptin concentrations were found to be higher in patients with CP, and non‐surgical periodontal therapy has been found to be effective in reducing leptin concentrations significantly 16 . Gundala et al concluded that elevated serum leptin concentrations in patients with CP could be considered a cardiovascular risk marker 17 . Longitudinal and cross‐sectional studies have shown positive associations between elevated serum leptin concentrations and cardiovascular risks including stroke, acute myocardial infarction, 18 chronic heart failure, 19 and coronary heart disease 20 …”

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confidence: 99%

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Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis

Purwar¹,

Khan²,

Mahdi³

et al. 2015

Journal of Periodontology

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis

Purwar¹,

Khan²,

Mahdi³

et al. 2015

Journal of Periodontology

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“…The study performed by Ay et al enrolled both the CP and aggressive periodontitis (AP) groups [40]. The study performed by Gundala et al enrolled both the systemically healthy group and the acute myocardial infarction (AMI) group [47]. The study performed by Davies et al provided the data on male and female subjects separately [44].…”

Section: Resultsmentioning

confidence: 99%

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

et al. 2017

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BackgroundThis study aimed to assess the difference in serum levels of leptin and adiponectin in patients with periodontitis and in periodontally healthy individuals and evaluate the changes in circulating leptin and adiponectin after periodontal therapy. Leptin and adiponectin are the most generally studied adipokines that function as inflammatory cytokines. Although the association between periodontitis and serum levels of leptin and adiponectin has been studied extensively, the results were not consistent.MethodsA systematic search of the Pubmed, Embase, Web of Science, and Cochrane Library up to September 2016 was conducted. The studies were screened and selected by two writers according to the specific eligibility criteria. The quality of included cross-sectional studies was assessed using the quality assessment form recommended by the Agency for Healthcare Research and Quality and Methodological Index for Nonrandomized Studies. The meta-analyses were conducted using the STATA 12.0 software.ResultsA total of 399 manuscripts were yielded and 25 studies were included in the present meta-analysis. Significantly elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis were observed in the subgroup analysis of body mass index (BMI) <30. The overall and subgroup analyses showed no significant change in the serum levels of leptin in patients with periodontitis after periodontal treatment. The subgroup analysis of systemically healthy patients showed no significant change in serum levels of adiponectin in patients with periodontitis after periodontal treatment.ConclusionsThe present meta-analysis supported elevated serum levels of leptin and decreased serum levels of adiponectin in patients with periodontitis compared with controls in the BMI <30 population. In systemically healthy patients with periodontitis, serum levels of leptin and adiponectin do not significantly change after periodontal treatment.

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“…In recent years, hyperleptinemia has also been identified as an independent risk factor for cardiovascular disease and myocardial infarction [37,38] directly linked to inflammation [39] and oxidative stress [3,35]. In the present study, we have found that leptin level increased proportionally with the degree of obesity (Table 2) and is positively correlated with adiposity (Pearson correlation with the percentage of fat mass r = 0.590, p < 0.001, data not shown), its serum concentration being similar to that previously reported by other authors [40,41].…”

Section: Discussionmentioning

confidence: 99%

Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants

et al. 2017

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Obesity has been related to an increased risk of multiple diseases in which oxidative stress and inflammation play a role. Gut microbiota has emerged as a mediator in this interaction, providing new mechanistic insights at the interface between fat metabolism dysregulation and obesity development. Our aim was to analyze the interrelationship among obesity, diet, oxidative stress, inflammation and the intestinal microbiota in 68 healthy adults (29.4% normal-weight). Diet was assessed through a food frequency questionnaire and converted into nutrients and dietary compounds using food composition tables. The intestinal microbiota was assessed by quantitative PCR, fecal short chain fatty acids by gas chromatography and serum biomarkers by standard protocols. Higher levels of malondialdehyde (MDA), C reactive protein (CRP), serum leptin, glucose, fat percentage and the intestinal Lactobacillus group were found in the obese people. Cluster analysis of body mass index, fat mass, glucose, LDL/HDL ratio, leptin, MDA and CRP classified the subjects into two groups. The levels of the intestinal Bacteroides-Prevotella-Porphyromonas group were lower in the cluster and linked to a higher pro-oxidant and pro-inflammatory status, whose individuals also had lower intake of fruits, dried fruits, and fish. These results could be useful for designing strategies targeted to obesity prevention.

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Association of Leptin in Periodontitis and Acute Myocardial Infarction

Abstract: Elevated serum leptin concentration was associated with increased BMI, GCP, and AMI and may serve as a risk marker for these conditions.

Cited by 25 publications

References 29 publications

Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis

Salivary and Serum Leptin Concentrations in Patients With Chronic Periodontitis

Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants

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