Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Akbari, Hamed; Aria, Hamid; Fooladi, Saba; Vakili, Sina; Masoumi, Maryam

doi:10.1186/s12872-018-0971-5

Cited by 16 publications

(14 citation statements)

References 30 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A growing body of evidence has suggested that some single nucleotide polymorphisms in the klotho gene were correlated with the circulating klotho levels and the susceptibility to hypertension 24 , salt hypertension 8 , and coronary artery disease 25 as well as the onset of stroke 26 . Though we did not find a significant relationship between the serum klotho concentrations, blood pressure, and PWV, we cannot exclude the possibility that genetic polymorphisms of the klotho gene may be associated with blood pressure and arterial stiffness.…”

Section: Discussionmentioning

confidence: 99%

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Liang

Wang

Wei

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid–femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP, which was measured using an oscillometric device. The serum klotho concentration was measured using an enzyme-linked immunosorbent assay and logarithmically transformed. Of the 716 participants (mean age: 51.9 ± 12.6 years), 467 (65.2%) were women. The median serum klotho concentration was 381.8 pg/mL. The serum klotho concentration did not significantly differ between patients with and without hypertension (P > 0.05) and between those with and without arterial stiffness (cfPWV ≥ 10 m/s) (P > 0.05). After adjusting for confounders, the serum klotho concentration was not significantly associated with the peripheral or central BP (P > 0.05) and cfPWV (P > 0.05). Our data indicated that the serum klotho concentration was not associated with BP or cfPWV in the general Chinese population.

show abstract

Section: Discussionmentioning

confidence: 99%

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Liang

Wang

Wei

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…KLB polymorphism is also reportedly related to coronary artery disease [20] and alcohol consumption [21]. In addition, studies in animals [11, 12] have shown that the AST/ALT ratio is elevated and triglyceride accumulation in the liver is increased in mice lacking KLB .…”

Section: Discussionmentioning

confidence: 99%

KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

Liu

Hao

Wang

et al. 2019

Aging

View full text Add to dashboard Cite

Klotho beta (KLB) mediates binding of fibroblast growth factor (FGF) 21 to the FGF receptor (FGFR). FGF21-KLB-FGFR signaling regulates multiple metabolic systems in the liver, and we hypothesized that FGF21, KLB and FGFR single-nucleotide polymorphisms (SNPs) are involved in hepatic lipid accumulation. The SNPs were detected in 1688 individuals divided into four groups: non-obese without non-alcoholic fatty liver disease (NAFLD), obese without NAFLD, non-obese with NAFLD, and obese with NAFLD. The A-allele of KLB SNP rs7670903 correlated with higher body mass index (P = 0.0005), and the A-allele frequency was higher in the obese than non-obese group (P = 0.003). The G-allele frequency of KLB rs7674434 and T-allele frequency of rs12152703 were higher in the obese with NAFLD than obese without NAFLD group (P = 0.004 and P = 0.006), but the genotype distribution between two non-obese groups did not differ. KLB rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (P = 0.03 and P = 0.04, respectively) and gamma-glutamyltransferase (P = 0.03 and P = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (P = 0.005 and P = 0.008, respectively). These findings suggest that KLB SNPs are related to obesity and hepatic inflammation and that they may be involved in the pathogenesis of NAFLD.

show abstract

“…This observational study was performed on a total of 238 individuals who were admitted for coronary angiography to Shafa Hospital of Kerman University of Medical Sciences, Kerman, Iran (from July 2014 to December 2015). Subject selection process was conducted as described elsewhere [17–19]. Briefly, all CAD-suspected participants were examined by coronary angiography, before which they went through CAD treatment as they were symptomatic, had a history of hospitalization in coronary care unit (CCU), or there was evidence of myocardial ischemia in noninvasive investigations such as an exercise test or perfusion imaging.…”

Section: Methodsmentioning

confidence: 99%

CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

Momeni-Moghaddam

Asadikaram

Abolhassani

et al. 2019

BMC Cardiovasc Disord

Self Cite

View full text Add to dashboard Cite

Background CD36 is associated with regulation of lipid metabolism, atherosclerosis, and blood pressure. Moreover, its variation may be involved in the development of hypertension and/or coronary artery disease (CAD). The present study was conducted to investigate the possible association of CD36 rs1761667 (G > A) polymorphism with hypertension and/or CAD in the southeastern of Iran. Methods The present observational study was composed of 238 subjects who were admitted for coronary angiography, and divided into four groups: 1) hypertensive without CAD (H-Tens, n = 52); 2) hypertensive with CAD (CAD + H-Tens, n = 57); 3) CAD without hypertension (CAD, n = 65); and 4) non-hypertensive without CAD as the control group (Ctrl, n = 64). The CD36 rs1761667 polymorphism was genotyped with PCR-RFLP method. Association between CD36 rs1761667 genotypes and the risk of CAD and hypertension was assessed using multinomial regression by adjusting for age, sex, creatinine, fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results In the present study, minor allele (A) frequency was 0.36. The genotype, but not allele frequency of the CD36 rs1761667 was significantly different between the four study groups ( p = 0.003). Furthermore, using a recessive inheritance model CD36 rs1761667 polymorphism was significantly associated with an increased risk of CAD with hypertension (OR = 5.677; 95% CI = 1.053–30.601; p = 0.043). However, using the dominant model of CD36 rs1761667 had a protective effect on H-Tens and CAD patients. Conclusion The present findings revealed an association between CD36 rs1761667 polymorphism and susceptibility to hypertension and/or CAD in a southeastern Iranian population.

show abstract

Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Cited by 16 publications

References 30 publications

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

Contact Info

Product

Resources

About