Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han

Abstract

ABSTRACT. Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis patients and 110 healthy controls using sequence-specific primer PCR analysis of genomic DNA. We found that the frequencies of KIR2DS1, 2DS3 and 3DS1 were significantly higher in patients than in the control group. In addition, the number of subjects carrying more than two activating KIR genes in the patient group was significantly higher than in the control group. The gene cluster containing KIR3DS1-Association of KIR with pulmonary tuberculosis ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (2) 1370-1378 (2012) 13712DL5-2DS1-2DS5 was also significantly more frequent in the patient group. In conclusion, KIR genes 2DS1, 2DS3 and 3DS1 appear to be associated with resistance to pulmonary tuberculosis in the Chinese Han population. KIR genes apparently have a role in resistance to pulmonary tuberculosis.

The deleterious effect of the HLA-C1/KIR2DL3 receptor-ligand combination on Chinese HIV Patients

“…According to the results of HLA genotyping, the frequencies of HLA-Bw4 and HLA-C1/C2 genotyping are basically the same as those of previous HLA-B/C genotyping researches based on Eastern Chinese population [29]. Furthermore, the frequency of KIR is also very close to the results of non-HIV patients in Eastern China [29,30].…”

Activating KIRs alter susceptibility to pulmonary tuberculosis in a South African population

“…The 3DS1 gene has been previously associated with TB susceptibility in the Lur population from Iran [18] and the Chinese Han population [19], with ORs of 0.39 and 2.12 respectively. The effect of this gene with regards to TB susceptibility has thus been found to differ between populations, with 3DS1 having a protective role in the SAC and Iranian population but increasing the risk of developing TB in the Chinese Han population.…”

Killer Cell Immunoglobulin-like Receptors and Their HLA Ligands are Related with the Immunopathology of Chagas Disease

“…KIR receptors of NK cells may contribute to the occurrence of different immunological and clinical responses to the same disease in a specific population [ 16 ]. Several studies have described the participation of KIR (and their ligands) in infectious diseases, such as AIDS [ 17 , 18 ], hepatitis C [ 19 , 20 ], tuberculosis [ 21 , 22 ], leprosy [ 23 , 24 ] and malaria [ 25 , 26 , 27 ]. KIR are also involved in autoimmune and inflammatory diseases such as pemphigus foliaceus, psoriasis, scleroderma, rheumatoid vasculitis and Crohn’s disease [ 28 , 29 , 30 , 31 , 32 ], as well as in many types of cancer [ 33 – 36 ] and the survival of transplant patients [ 37 ].…”