Association of kidney function and brain health: A systematic review and meta-analysis of cohort studies

Tang, Xingyao; Han, Yipeng; Chai, Yin-He; Gong, Hongjian; Xu, Hui; Patel, Ikramulhaq; Qiao, Yu-Shun; Zhang, Jinyan; Cardoso, Marly Augusto; Zhou, Jianbo

doi:10.1016/j.arr.2022.101762

Cited by 14 publications

(13 citation statements)

References 93 publications

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“…Cerebral small vessel disease (CSVD) is a cerebrovascular architectural disorder characterized by insidious onset and progressive cognitive (Wang et al, 2021), gait (Su et al, 2022), emotional (Li et al, 2022), and urinary disturbances (Tang et al, 2022), which influence the quality of life, resulting in heavy economic and social burdens. White matter hyperintensities (WMHs) of presumed vascular origin, which are typical neuroimaging markers of CSVD (Wardlaw et al, 2013), have aroused broad concern owing to their high occurrence and potential association with vascular cognitive dysfunction (Roseborough et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Huang,

Zhou,

Ren

et al. 2023

J of Neuroscience Research

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White matter hyperintensities (WMHs) of presumed vascular origin are important imaging biomarkers of cerebral small vessel disease (CSVD). Previous studies have verified abnormal functional brain networks in CSVD. However, most of these studies rely on static functional connectivity, and only a few focus on the varying severity of the WMHs. Hence, our study primarily explored the disrupted dynamic functional network connectivity (dFNC) and topological organization variance in patients with WMHs. This study included 38 patients with moderate WMHs, 47 with severe WMHs, and 68 healthy controls (HCs). Ten independent components were chosen using independent component analysis based on resting‐state functional magnetic resonance imaging. The dFNC of each participant was estimated using sliding windows and k‐means clustering. We identified three reproducible dFNC states. Among them, patients with WMHs had a significantly higher occurrence in the sparsely connected State 1, but a lower occurrence and shorter duration in the positive and stronger connected State 3. Regarding topological organization variance, patients with WMHs showed higher variance in local efficiency but not global efficiency compared to HCs. Among the WMH subgroups, patients with severe WMHs showed similar but more obvious alterations than those with moderate WMHs. These altered network characteristics indicated an imbalance between the functional segregation and integration of brain networks, which was correlated with global cognition, memory, executive functions, and visuospatial abilities. Our study confirmed aberrant dFNC state metrics and topological organization variance in patients with moderate‐to‐severe WMHs; thus, it might provide a new pathway for exploring the pathogenesis of cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Huang,

Zhou,

Ren

et al. 2023

J of Neuroscience Research

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“…It has been suggested that kidney function is linked to brain activity, 54 and changes in kidney function may play a role in the development and progression of AD. Studies have shown that the MRI images of the brains of AD patients were similar to that of kidney patients 55 and a systematic meta-analysis demonstrated that cognitive impairment is significantly related to malfunction of kidney.…”

Section: Discussionmentioning

confidence: 99%

Using In Vivo Intact Structure for System-wide Quantitative Analysis of Changes in Proteins

Yates

Son

Kim

et al. 2023

Preprint

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Mass spectrometry-based methods can provide a global expression profile and structural readout of proteins in complex systems. Preserving the in vivo conformation of proteins in their innate state is challenging during proteomic experiments. Here, we introduce an approach using perfusion of reagents to create a whole animal in vivo protein footprinting method that adds dimethyl labels to exposed lysine residues on intact proteins to maintain information on protein conformations. When this approach was used to measure dynamic structural changes during Alzheimer’s disease (AD) progression in a mouse model, we detected 433 proteins that underwent structural changes attributed to AD, independent of aging, across 7 tissues. We identified structural changes of co-expressed proteins and linked the communities of these proteins to their biological functions. Our findings show that structural alterations of proteins precede changes in expression, thereby showing the value of in vivo protein conformation measurement. Our method represents a new strategy for untangling mechanisms of proteostasis dysfunction caused by protein misfolding. In vivo whole-animal footprinting should have broad applicability for discovering conformational changes in systemic diseases and therapeutic interventions.

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“…It has been suggested that kidney function is linked to brain activity, 55 and changes in kidney function may play a role in the development and progression of AD. Studies have shown that the MRI images of the brains of AD patients were similar to that of kidney patients 56 and a systematic metaanalysis demonstrated that cognitive impairment is significantly related to malfunction of kidney.…”

Section: Discussionmentioning

confidence: 99%

In vivoProtein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer’s Disease

Son

Kim

Diedrich

et al. 2023

Preprint

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Numerous studies have investigated changes in protein expression at the system level using proteomic mass spectrometry, but only recently have studies explored the structure of proteins at the proteome level. We developed covalent protein painting (CPP), a protein footprinting method that quantitatively labels exposed lysine, and have now extended the method to whole intact animals to measure surface accessibility as a surrogate of in vivo protein conformations. We investigated how protein structure and protein expression change as Alzheimer's disease (AD) progresses by conducting in vivo whole animal labeling of AD mice. This allowed us to analyze broadly protein accessibility in various organs over the course of AD. We observed that structural changes of proteins related to 'energy generation,' 'carbon metabolism,' and 'metal ion homeostasis' preceded expression changes in the brain. We found that proteins in certain pathways undergoing structural changes were significantly co-regulated in the brain, kidney, muscle, and spleen.

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Association of kidney function and brain health: A systematic review and meta-analysis of cohort studies

Cited by 14 publications

References 93 publications

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Using In Vivo Intact Structure for System-wide Quantitative Analysis of Changes in Proteins

In vivoProtein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer’s Disease

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