Association of keloids with systemic medical conditions: a retrospective analysis

The Importance of Patient Registries in Skin of Color

“…Similarly, the Genetic Causes of Keloid Formation Study at the University of Texas Southwestern Medical Center was founded for the purpose of learning more about keloids, the pathophysiology of their formation, the role of genetic predisposition, and associated disorders. Using data from this registry, researchers have been able to show a significant association between keloid scars, obesity, and hypertension in African American patients (Adotama et al, 2016). This finding has sparked further investigations to elucidate mechanisms common to the pathogenesis of these conditions and confirm the association of keloids with systemic medical conditions.…”

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models

“…Hypertension Hypothesis Dustan (1995) first hypothesized that the differences in growth factor abnormalities that are conducive to keloid scarring in the black population, could also be responsible for the development of hypertension and therefore explain the differences in hypertension severity between the black and white population. A significant increase in hypertension rates has in fact been reported in keloid-prone patients compared with non-keloid formers in both the African-American (Snyder et al, 1996;Adotama et al, 2016;Rutherford and Glass, 2017) and Caucasian population (Snyder et al, 1996). Ogawa et al (2013) also reported that severe keloid cases (multiple or large >10 cm 2 ) in Japan were significantly more likely to have hypertension than patients with mild keloids (<2 or <10 cm 2 ).…”

A case–control study analyzing the association of keloids with hypertension and obesity

“…Previous results from the Genetic Causes of Keloid Formation Study (GCKFS), an IRB-approved keloid registry, showed African-Americans with keloids reported having hypertension and obesity at increased rates compared to the general African-American population. 1 We formally tested for any association of keloids with these comorbidities using objective measures.…”