“…Kappa light chain restriction was strongly associated with peripheral neuropathy (RR = 4.31, 95% CI = 1.58 to 11.78; P = .004) in our MGUS cohort. 3 Electromyographic studies identified 14 patients (64%) with distal symmetric axonal neuropathy and eight patients (36%) with chronic inflammatory demyelinating polyneuropathy, which were findings comparable with the previously published data. 1,2 Clinically severe peripheral neuropathy was identified in 11 (50%) patients, all of which were subsequently treated with intravenous immunoglobulin infusions at 1 g/kg every 3 weeks.…”