Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity

Elizondo‐Montemayor, Leticia; Silva-Platas, Christian; Torres‐Quintanilla, Alejandro; López, Carlos E. Rodríguez; Ruiz–Esparza, Guillermo U.; Reyes-Mendoza, Eric; García‐Rivas, Gerardo

doi:10.1155/2017/2628968

Cited by 32 publications

(36 citation statements)

References 48 publications

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“…As such, there is currently no universally accepted ‘reference range’ or normal value for circulating irisin in healthy individuals and some even question its existence [ 39 ]. Although it has been suggested that a ‘normal’ circulating concentration of irisin may fall in the narrow range of 3.6–4.6 ng/ml [ 40 ], plasma irisin levels similar to those observed in the present study have been independently reported previously [ 41 , 42 ]. Moreover, the ELISA used in the present study has been previously tested against both Western blotting [ 43 ] and mass spectrometry [ 44 ].…”

Section: Discussionsupporting

confidence: 86%

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Rana

Pararasa

Afzal

et al. 2017

Cardiovasc Diabetol

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BackgroundIrisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to induce white adipose tissue to take on a brown adipose tissue-like phenotype, suggesting that irisin and its receptor may represent a novel molecular target for the treatment of obesity and obesity-related diabetes. Previous reports provide conflicting evidence regarding circulating irisin levels in patients with type 2 diabetes (T2DM).MethodsThis study investigated plasma irisin concentrations in 79 T2DM individuals, assessing potential associations with measures of segmental body composition, markers of endothelial dysfunction and peripheral blood mononuclear cell telomere length (TL).ResultsResting, overnight-fasted plasma irisin levels were significantly higher in this group of T2DM patients compared with levels we previously reported in healthy volunteers (p < 0.001). Moreover, plasma irisin displayed a positive correlation with body mass index (p = 0.04), body fat percentage (p = 0.03), HbA1c (p = 0.03) and soluble E-selectin (p < 0.001). A significant negative association was observed between plasma irisin and visceral adiposity (p = 0.006) in T2DM patients. Multiple regression analysis revealed that circulating soluble E-selectin levels could be predicted by plasma irisin (p = 0.004). Additionally, cultured human umbilical vein endothelial cells (HUVEC) exposed to 200 ng/ml irisin for 4 h showed a significant fourfold increase in E-selectin and 2.5-fold increase in ICAM-1 gene expression (p = 0.001 and p = 0.015 respectively), and there was a 1.8-fold increase in soluble E-selectin in conditioned media (p < 0.05).ConclusionThese data suggest that elevated plasma irisin in T2DM is associated with indices of adiposity, and that irisin may be involved in pro-atherogenic endothelial disturbances that accompany obesity and T2DM. Accordingly, irisin may constitute a potentially novel therapeutic opportunity in the field of obesity and cardiovascular diabetology.

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Section: Discussionsupporting

confidence: 86%

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Rana

Pararasa

Afzal

et al. 2017

Cardiovasc Diabetol

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“…These concentrations were higher (P > 0.05) than those observed in the group with normal BMI. This is consistent with the results of another study in which the overweight and obese groups showed no difference compared with the normal weight group (29).…”

Section: Discussionsupporting

confidence: 92%

Assessment of Iron Metabolism-Related Parameters in Obese Children

Donma

Güngör

Yılmaz

et al. 2019

Avicenna J Med Biochem

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Objectives: The aim of the study was to assess the possible associations among biochemical parameters that may be correlated with the possible mechanisms of iron metabolism in healthy children with normal body mass index (BMI), along with morbid obese (MO) children with and without metabolic syndrome (MetS). Methods: To this end, children aged 6-18 years with no history of any acute or chronic diseases were selected as the population of this prospective case-control study. Thirty MO children (with BMI higher than 99th percentile and without MetS findings), 28 MO children (with BMI higher than 99th percentile and with MetS), and 30 healthy children (with BMI values between 15th and 85th percentiles) participated in the study. Then, anthropometric measurements were recorded, followed by performing the complete blood count and serum iron profile. In addition, ferritin, transferrin, hepcidin, irisin, ferroportin, brain-derived neurotrophic factor (BDNF), WISP1, and PTP1/fortilin levels were measured using ELISA. Finally, statistical analyses were performed and P<0.05 was considered as the level of statistical significance. Results: Significant differences were obtained among the groups regarding anthropometric measurements, blood pressures, triacylglycerols, and high-density lipoprotein cholesterol levels. Further, there was a tendency toward an iron deficiency in both MO groups while an increase in ferritin levels was significant in the MetS group. However, BDNF, hepcidin, and ferroportin demonstrated no significant difference among the groups. Eventually, although the above-mentioned parameters were statistically insignificant, fortilin levels indicated a gradual decrease whereas irisin levels represented an increase from control group toward morbid obesity and MetS. Conclusion: In our study, obesity severity and the tendency toward iron deficiency were in accordance with each other. Particularly, different WISP-1 levels in the groups may help predict future complications, along with its use in diagnosing obesity.

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“…Previous work from Huh and coworkers showed that circulating irisin declines in parallel with age-related muscle loss, and documented a strong positive association between irisin and biceps circumference, implying that muscle mass is the main determinant of circulating irisin levels in humans 13 . Other www.nature.com/scientificreports www.nature.com/scientificreports/ studies prompted similar evidence of a positive correlation between irisin and fat-free mass 15,18,40,41 . Hence, the positive correlation observed between irisin and muscle mass agrees with the divergent obese phenotypes of the populations studied 42 .…”

Section: Discussionmentioning

confidence: 75%

“…Although dual X-ray absorptiometry (DXA) is considered the gold standard for the assessment of body composition, the very obese phenotype of the patients herein studied exceeded the DXA weigh limit in many cases. Nevertheless, BIA has already proven useful in clinical settings investigating irisin in relation to body composition 15,40,41,46 . Because our study was conducted in PWS patients with severe obesity, its results may not extend to non-obese PWS patients.…”

Section: Discussionmentioning

confidence: 99%

Irisin levels in genetic and essential obesity: clues for a potential dual role

Mai

Grugni

Mele

et al. 2020

Sci Rep

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irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. its potential link to fat accumulation and metabolic dysfunction is debated. We sought to explore the relationship between circulating irisin and components of body composition in two different phenotypes of severe obesity. For this purpose, 30 obese adults with Prader-Will syndrome (PWS) (age 35.7 ± 1.5 y, BMI 45.5 ± 1.5 kg/m 2) and 30 adult controls with common obesity (age 34.9 ± 1.7 y, BMI 46.8 ± 1.4 kg/m 2) underwent analysis of irisin levels, metabolic profile, body composition and resting energy expenditure (REE). Normal irisin levels were obtained from a group of 20 lean donors (age 32.4 ± 1.5 y, BMI 23.8 ± 0.8 kg/m 2). Expected differences in body composition and metabolic profile existed between study groups. PWS exhibited lower muscle mass (p < 0.001), FFM (p < 0.001), REE (p < 0.001), as well as insulin (p < 0.05), HOMA-IR (p < 0.05) and triglycerides levels (p < 0.05) than controls with common obesity. In PWS, irisin levels were significantly lower and overall less dispersed than in controls with common obesity (p < 0.05), while being similar to values recorded in lean subjects. to explore the relation between irisin and body composition in obesity, univariate correlation analysis in the obese populations as a whole showed positive associations between irisin and muscle mass (p = 0.03) as well as REE (p = 0.01), which disappeared when controlled for the pWS status. noticeably, a positive association became evident between irisin and %fM after controlling for the pWS status (p = 0.02). Also positive were associations between irisin and insulin (p = 0.02), HOMA-IR (p = 0.02) and triglycerides (p = 0.04). In stepwise multivariable regression analysis, irisin levels were independently predicted by the pWS status (p = 0.001), %FM (p = 0.004) and triglycerides (p = 0.008). Current results suggest that obese adults with PWS harbor lower irisin levels than individuals with common obesity. the divergent models of obesity herein studied suggest a potential link between circulating irisin and muscle mass and metabolic dysfunction relating to adiposity. Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by neonatal hypotonia associated with poor suck, followed by the lack of a sense of satiety with obsessive craving for food in childhood and gradual development of morbid obesity in adulthood unless eating is externally controlled 1-4. Further clinical features include body dysmorphisms, developmental disability, cognitive and behavioral disorders, endocrine dysfunctions leading to short stature, hypogonadism and hypothyroidism 1. PWS occurs because of the lack of expression of genes located on the paternal chromosome 15q11.2-q13. Three main genetic mechanisms have been recognized in determining PWS: deletion of the paternal chromosome 15 (del15q11-q13), maternal uniparental disomy of chromosome 15 (UPD15), and imprinting defects 2 .

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Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity

Cited by 32 publications

References 48 publications

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

Assessment of Iron Metabolism-Related Parameters in Obese Children

Irisin levels in genetic and essential obesity: clues for a potential dual role

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