Association of IP-10 gene polymorphism with susceptibility to Enterovirus 71 infection

Yang, Jing; Chen, Zhenzhen; Lv, Teng; Li, Peipei; Chen, Zongbo

doi:10.3892/br.2013.64

Cited by 6 publications

(7 citation statements)

References 11 publications

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“…Variants of type II IFN and other chemokines also contributed to EV71 HFMD. Interferon gamma induced proteins-10 (IP-10) gene −1596 T was the risk factor of EV71 infection 20 . Interleukin 10 (IL-10) and interferon gamma (IFN-γ) gene SNPs were associated with the susceptibility to EV71 HFMD encephalitis 21 .…”

Section: Discussionmentioning

confidence: 99%

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A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection

Zou

Zhang

Shao-yuan

et al. 2015

Sci Rep

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Enterovirus 71 (EV71), one of the major pathogens of Hand, foot and mouth disease (HFMD), results in millions of infections and hundreds of deaths each year in Southeast Asia. Biased infection and variable clinical manifestations of EV71 HFMD indicated that host genetic background played an important role in the occurrence and development of the disease. We identified the mRNA profiles of EV71 HFMD patients, which type I interferon (IFN) pathway related genes were down-regulated. Four single nucleotide polymorphisms (SNPs) of type I IFN receptor 1 (IFNAR1) were chosen to analyze their relationships to EV71 infection. We found that genotype GG of promoter variant rs2843710 was associated with the susceptibility and severity to EV71 HFMD. In addition, we assessed the regulatory effects of rs2843710 to IFN stimulated genes (ISGs), and found that the expressions of IFNAR1, OAS1 and MX1 were significantly lower in patients with rs2843710 genotype GG. And rs2843710 allele G showed weaker transcriptional activity compared with allele C. Our study indicated that rs2843710 of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations, acting as a functional polymorphism by regulating ISGs expression, such as OAS1 and MX1.

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Section: Discussionmentioning

confidence: 99%

“…Polymorphisms of type I IFN signaling pathway genes like MX1 and OAS1 have been reported to link to the occurrence and development of HFMD 18 19 . Other variants of type II IFN related genes IFN-γ, IL-10 and IP-10, chemokines CCL2 and CXCL10 and eNOS also contributed to susceptibility or severity to EV71 infection 20 21 22 23 .…”

mentioning

confidence: 99%

A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection

Zou

Zhang

Shao-yuan

et al. 2015

Sci Rep

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“…In EV71-infected HFMD patients, the levels of IP-10 were significantly elevated as compared to healthy controls [24]. The association between IP-10 polymorphism in children and EV71infection has been studied [46]. The result showed that the frequency of carrying CT+TT genotype (10.3) and T allele (6.0%) in EV71infected cases was significantly lower than that of the controls (29.2 and 15.6%), which indicated that IP-10-1596 T allele may be a beneficial factor for EV71 infection.…”

Section: Chemokinesmentioning

confidence: 99%

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Zhang

Huang

et al. 2020

Mediators of Inflammation

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Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-infected HFMD cases lead to severe complications such as aseptic meningitis, encephalitis, acute flaccid paralysis, pulmonary edema, cardiorespiratory complication, circulatory disorders, poliomyelitis-like paralysis, myocarditis, meningoencephalitis, neonatal sepsis, and even death. The mechanism of EV71 pathogenesis has been studied extensively, and the regulation of host immune responses is suspected to aggravate EV71induced severe complications. Recently, several cytokines or chemokines such as TNF-α, IFN-γ, IL-1β, IL-18, IL-33, IL-37, IL-4, IL-13, IL-6, IL-12, IL-23, IL-27, IL-35, IL-10, IL-22, IL-17F, IL-8, IP-10, MCP-1, G-CSF, and HMGB1 have been reported to be associated with severe EV71 infection by numerous research teams, including our own. This review is aimed at summarizing the pathophysiology of the cytokines and chemokines with severe EV71 infection.

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“…CYP19A1 gene polymorphism is associated with reduced aromatase activity, which can lead to the development of endometriosis (Wang et al, 2010;Zaree et al, 2015;Hosseini et al, 2016;Abu Hashim, 2016). While previous studies have investigated the association between CYP19A1 and risk of endometriosis, the results were inconsistent (Hur et al, 2007;Vietri et al, 2009;Yang et al, 2010;Szczepańska et al, 2013;Wang et al, 2012Wang et al, , 2014. We have shown that there is a significant correlation between CYP19A1 rs2899470 and risk of endometriosis in a Chinese population.…”

Section: Discussionmentioning

confidence: 69%

Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population

Tuo¹,

He²,

Yan³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Endometriosis is a common, complicated, and highly heterogeneous endocrine disease. Many genetic factors could affect the development of endometriosis. We performed a case-control study to evaluate the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis in a Chinese population. Between March 2014 and October 2015, 262 endometriosis patients and 275 control subjects were recruited from the Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism. Individuals carrying the TT genotype of CYP19A1 rs2899470 expressed a higher risk of endometriosis than those carrying the GG genotype, and the adjusted ORs (95%CI) was 2.33 (1.27-4.33). Moreover, those with the TG + TT genotype were correlated with an elevated risk of endometriosis, compared to those with the GG genotype (OR = 1.48, 95%CI = 1.03-2.13). However, GSTM1, GSTT1, and GSTP1 rs1695 polymorphisms did not affect the pathogenesis of endometriosis. In conclusion, our results suggested that CYP19A1 rs2899470 polymorphism is associated with risk for endometriosis in the Chinese population.

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Association of IP-10 gene polymorphism with susceptibility to Enterovirus 71 infection

Cited by 6 publications

References 11 publications

A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection

A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection

Predicting Severe Enterovirus 71-Infected Hand, Foot, and Mouth Disease: Cytokines and Chemokines

Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population

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