Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time

Liang, Zhen; Xu, Chen; Luo, Yi

doi:10.1186/s40779-017-0118-5

Cited by 6 publications

(3 citation statements)

References 28 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iodine deficiency prevalence, as measured by the presence of goiter in children (8–10 years), ranged from 2.2 to 14%, with 2.2% being the national average and 11–14% in Hebei province [ 46 , 100 , 106 ]. The median urinary iodine concentration (UIC) nationally for children (8–10 years) was less than 250 μg (227–239 μg/L nationally in 2011; 211 μg/L in Hebei, Guangxi and Zhejiang; and 191 μg/L in Zhejiang province) [ 45 , 46 , 86 , 100 , 106 ]. In Hebei, the median UIC was 419 μg/L; additionally, 68% of the study populations were > 300 μg/L, while this was 28% at the national level [ 46 , 100 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic Literature Review of the Nutrient Status, Intake, and Diet Quality of Chinese Children across Different Age Groups

Ayling

Muhardi³

et al. 2023

Nutrients

View full text Add to dashboard Cite

There is a lack of comprehensive reports on nutrient deficiencies and dietary intake among various age groups of children in China. The objective of this review is to provide an overview of the nutrient status, intake, and diet adequacy of Chinese children (0–18 years old). PubMed and Scopus were searched for literature published between January 2010 and July 2022. A systematic review approach with a quality assessment was performed to analyze 2986 identified articles in English and Chinese. Eighty-three articles were included in the analysis. In younger children, anemia and iron and Vitamin A deficiencies remain severe public health problems, despite high Vitamin A and adequate iron intake. In older children, a high prevalence of selenium; Vitamin A and D deficiencies; and inadequate intakes of Vitamins A, D, B, C, selenium, and calcium were reported. Intakes of dairy, soybeans, fruits, and vegetables were below recommended levels. High intakes of iodine, total and saturated fat, and sodium and low dietary diversity scores were also reported. As nutritional concerns vary with age and region, future nutrition interventions should be tailored accordingly.

show abstract

Section: Resultsmentioning

confidence: 99%

Systematic Literature Review of the Nutrient Status, Intake, and Diet Quality of Chinese Children across Different Age Groups

Ayling

Muhardi³

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…In a cross-sectional study in Guinea-Bissau in school age children, rate of goiter was high (73.5%) despite median UIC of 110 µg/L [18]. Similarly, in a longitudinal continuous study in Chinese population iodized salt was not associated with rate of goiter [19]. Knowledge of importance of iodine was low and needs effective intervention.…”

Section: Urinary Iodine Concentration (Uic) and Goitermentioning

confidence: 91%

High variability of iodine in iodized salt and urine from rural households in Sidama zone, Southern Ethiopia: A cross-sectional study

Tafere¹,

Stoecker²

2020

AJFAND

View full text Add to dashboard Cite

Iodine is essential for the synthesis of thyroid hormones which regulate the metabolic processes of most cells and play important roles in human growth and development. Iodine deficiency has long been one of the most common nutritional problems in the world. Ethiopia, particularly the study population (Sidama) has a history of severe iodine deficiency. The purpose of the study was to assess urinary iodine concentration, level of goiter in mothers and school-age children and household salt iodine concentration in households 10 months after launch of the national salt iodization program. A crosssectional study was conducted on a randomly selected sample of women and schoolchildren. Goiter was assessed by palpation. Concentrations of iodine in salt, urine and water were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). The study included 193 mothers and 76 children. The median (IQR) urinary iodine concentration (UIC) was 143 (84, 202) µg/L in the mothers and 187 (102, 278) µg/L in the children. Mothers' UIC ranged from 17 to 767.2 µg/L and children's UIC ranged from 19 to 739 µg/L. Goiter prevalence was high in both mothers (76%) and children (79%). The median household salt iodine concentration (SIC) was 8.1 (4.3, 13.4) ppm (mg/kg) with a range of 0 to 42 ppm. None of the water samples contained iodine above the detection limit of 1 µg/L. Despite the launch of the salt iodization program in Ethiopia, 94% of the study participants were not aware that they used iodized salt and 88% did not know the benefits of iodized salt. The major source of iodine for this population was iodized salt; however, the salt at household level contained minimal but variable amounts of iodine. Low concentration of iodine in salt may be further compounded by storage, handling and cooking techniques. The high variability of salt iodine concentration (SIC) was also reflected in the UIC of the mothers and children.

show abstract

“…Iodine deficiency disorders are among the biggest public health problems worldwide today, with populations in southern Asia, Latin America, and Sub-Saharan Africa particularly affected [206]. It is noteworthy that insufficient iodine intake in adults results in a high risk of multiple cancers (goiter, mammary cancer); iodine supplementation has been considered as an adjuvant therapy for these cancers [129,207]. Research by Aceves et al [128] and Alfaro et al [129] suggested the participation of PPARs in the antineoplastic effect of iodine; I 2 in drinking water effectively dampened the expression of Ppar-α and elevated that of Ppar-γ in tumoral mammary glands of rats.…”

Section: Other Essential Trace Elementsmentioning

confidence: 99%

Trace Elements, PPARs, and Metabolic Syndrome

Shi

Zou

Shen

et al. 2020

IJMS

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is a constellation of metabolic derangements, including central obesity, insulin resistance, hypertension, glucose intolerance, and dyslipidemia. The pathogenesis of MetS has been intensively studied, and now many factors are recognized to contribute to the development of MetS. Among these, trace elements influence the structure of proteins, enzymes, and complex carbohydrates, and thus an imbalance in trace elements is an independent risk factor for MetS. The molecular link between trace elements and metabolic homeostasis has been established, and peroxisome proliferator-activated receptors (PPARs) have appeared as key regulators bridging these two elements. This is because on one hand, PPARs are actively involved in various metabolic processes, such as abdominal adiposity and insulin sensitivity, and on the other hand, PPARs sensitively respond to changes in trace elements. For example, an iron overload attenuates hepatic mRNA expression of Ppar-α; zinc supplementation is considered to recover the DNA-binding activity of PPAR-α, which is impaired in steatotic mouse liver; selenium administration downregulates mRNA expression of Ppar-γ, thereby improving lipid metabolism and oxidative status in the liver of high-fat diet (HFD)-fed mice. More importantly, PPARs' expression and activity are under the control of the circadian clock and show a robust 24 h rhythmicity, which might be the reasons for the side effects and the clinical limitations of trace elements targeting PPARs. Taken together, understanding the casual relationships among trace elements, PPARs' actions, and the pathogenesis of MetS is of great importance. Further studies are required to explore the chronopharmacological effects of trace elements on the diurnal oscillation of PPARs and the consequent development of MetS.

show abstract

Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time

Cited by 6 publications

References 28 publications

Systematic Literature Review of the Nutrient Status, Intake, and Diet Quality of Chinese Children across Different Age Groups

Systematic Literature Review of the Nutrient Status, Intake, and Diet Quality of Chinese Children across Different Age Groups

High variability of iodine in iodized salt and urine from rural households in Sidama zone, Southern Ethiopia: A cross-sectional study

Trace Elements, PPARs, and Metabolic Syndrome

Contact Info

Product

Resources

About