Association of interleukin (IL)-4 gene intron 3 VNTR polymorphism with multiple sclerosis in Turkish population

Karakuş, Nevin; Yığıt, Serbülent; Kurt, G. Semiha; Çevik, Betül; Demir, Osman; Ateş, Ömer

doi:10.1016/j.humimm.2013.05.011

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…We only acknowledge that some VNTR IL-4 polymorphisms could affect the host susceptibility to brucellosis which was caused by intracellular Brucella melitensis [99]. As far as we know, any VNTR polymorphism at IL-4 intron 3 is also associated with other immunological diseases, such as rheumatoid arthritis, immune thrombocytopenic purpura, systemic lupus erythematosus, multiple sclerosis and knee osteoarthritis [98,100,101]. This is because IL-4 is one of the major cytokines responsible for both innate and adaptive immunity which influences various cell types.…”

Section: Variable Number Of Tandem Repeat (Vntr) In Interleukin 4: Gementioning

confidence: 99%

“…In contrast, the polymorphism of 3R3R, 3R1R, and 2R2R does not contribute to any susceptibility towards enteric fever [15]. It was suggested that the IL-4 VNTRs polymorphism might affect the transcriptional activity, including the higher expression of IL-4, leading to a shift in the Th1/Th2 balance toward Th2 [15,101]. It is well known that the protective immune response against S. Typhi is the maturation of Th1 cells, apart from the B cells [38].…”

Section: Variable Number Of Tandem Repeat (Vntr) In Interleukin 4: Gementioning

confidence: 99%

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Human Genetic Variation Influences Enteric Fever Progression

Yee

Tan

Hee

et al. 2021

Cells

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In the 21st century, enteric fever is still causing a significant number of mortalities, especially in high-risk regions of the world. Genetic studies involving the genome and transcriptome have revealed a broad set of candidate genetic polymorphisms associated with susceptibility to and the severity of enteric fever. This review attempted to explain and discuss the past and the most recent findings on human genetic variants affecting the progression of Salmonella typhoidal species infection, particularly toll-like receptor (TLR) 4, TLR5, interleukin (IL-) 4, natural resistance-associated macrophage protein 1 (NRAMP1), VAC14, PARK2/PACRG, cystic fibrosis transmembrane conductance regulator (CFTR), major-histocompatibility-complex (MHC) class II and class III. These polymorphisms on disease susceptibility or progression in patients could be related to multiple mechanisms in eliminating both intracellular and extracellular Salmonella typhoidal species. Here, we also highlighted the limitations in the studies reported, which led to inconclusive results in association studies. Nevertheless, the knowledge obtained through this review may shed some light on the development of risk prediction tools, novel therapies as well as strategies towards developing a personalised typhoid vaccine.

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Section: Variable Number Of Tandem Repeat (Vntr) In Interleukin 4: Gementioning

confidence: 99%

Section: Variable Number Of Tandem Repeat (Vntr) In Interleukin 4: Gementioning

confidence: 99%

Human Genetic Variation Influences Enteric Fever Progression

Yee

Tan

Hee

et al. 2021

Cells

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“…There are, however, several studies on IL-4 VNTR gene polymorphism and other autoimmune and inflammatory diseases from Turkey. Their associations with alopecia areata [41], coronary artery disease [42], diabetic peripheral neuropathy [43], knee osteoarthritis [44], multiple sclerosis [45], and recurrent aphthous stomatitis [46] have been studied in the Turkish population previously. Additionally, IL-4 and IL-1RA VNTR gene polymorphisms have been found related to type 2 diabetes mellitus and frailty syndrome together [47,48].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population

Pehlıvan

Oyacı

Tuncel

2022

Egypt J Med Hum Genet

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Background Pro-inflammatory/anti-inflammatory cytokine imbalance in cerebrospinal fluid or plasma of schizophrenia (SCZ) and bipolar disorder (BD) patients has been documented over the last decade. We aim to examine the interleukin-1 receptor antagonist (IL-1RA) and IL-4 variable number of tandem repeat (VNTR) polymorphisms in SCZ and BD patients by comparing them with healthy controls. Methods Two hundred and thirty-four unrelated patients (127 patients with SCZ, 107 patients with BD) and 204 healthy controls were included. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirm the diagnosis. In addition, the polymerase chain reaction technique was used to investigate IL-1RA and IL-4 VNTR polymorphisms. Results Our results showed that the distributions of IL-1RA and IL-4 genotype and the allele frequencies of SCZ or BD patients were not significantly different from the healthy control group. IL-1RA allele 2 homozygous genotype and IL-1RA allele 2 frequencies were non-significantly higher among SCZ patients than in controls. Conclusions Our study indicates that the IL-1RA and IL-4 VNTR polymorphisms are not considered risk factors for developing SCZ and BD among Turkish patients.

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“…IL-4 VNTR gene polymorphisms have been the subject of various studies from Turkey. Their association with coronary artery disease, knee osteoarthritis, alopecia areata, diabetic peripheral neuropathy, recurrent aphthous stomatitis (RAS), multiple sclerosis, and Behçet's disease in Turkish population have all been studied previously [43][44][45][46][47][48][49]. IL-4 VNTR gene polymorphisms have also been linked with immune thrombocytopenic purpura (ITP) and asthma in the current literature [50,51].…”

Section: Discussionmentioning

confidence: 99%

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

Kuran¹,

Aslan²,

Haytoğlu³

et al. 2019

Turk J Med Sci

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Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction. Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient and control groups (P = 0.235). Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasal polyposis.

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Association of interleukin (IL)-4 gene intron 3 VNTR polymorphism with multiple sclerosis in Turkish population

Cited by 10 publications

References 25 publications

Human Genetic Variation Influences Enteric Fever Progression

Human Genetic Variation Influences Enteric Fever Progression

Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

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