Association of interleukin-6 in women with persistence of DNA-HPV: a nested case–control study

Abstract

The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.

Relationship between the interleukin‐6‐174 gene and mannose‐binding lectin codon 54 gene polymorphisms and condyloma acuminatum

“…Therefore, it is suggested that MBL may promote the rapid resolution of acute inflammation by increased production of IL‐6 as well as by the rapid clearance of foreign microbes and necrotic debris, which provoke acute inflammatory responses. On the other hand, MBL itself can help the clearance of infections agents and up‐regulate the production of IL‐6, promoting early termination of the acute inflammatory process and rapid transition to adaptive immune process …”

“…Possible effects of the results of IL ‐6 and Mannose‐binding lectin ( MBL )‐2 gene polymorphism and their products on Human papillomaviruses ( HPV ) infections …”

“…On the other hand, MBL itself can help the clearance of infections agents and up-regulate the production of IL-6, promoting early termination of the acute inflammatory process and rapid transition to adaptive immune process. [9][10][11][12][45][46][47][48][49] Possible effects of the results of IL-6 and MBL-2 gene polymorphism and their products on HPV infections are shown Fig. 4.…”

“…4. [2][3][4][9][10][11][12]17,[19][20][21][45][46][47][48][49] To our knowledge, this is the first prospective study to report a possible correlation between gene polymorphism IL-6 (-174 G/C) together with MBL2 gene polymorphism and susceptibility to CA. In conclusions, these results suggest that the IL-6 G/G and MBL AA gene polymorphisms may be potential risk factor and that the IL-6 G/C and MBL AB polymorphisms may be a protective factor for occurrence, recurrence and resistance to therapy of CA in this study group, although further investigations in other populations are required to confirm this hypothesis.…”

Vias de transdução de sinal e polimorfismo de <i>Toll-like Receptors</i> na carcinogenese por HPV

“…however, when activated, NFkB inhibits proliferation and immortalization (Vandermark et al, 2012). HPV persistence seems to be associated with low IL-6 levels (Rosa et al, 2012), and the rs5743836 polymorphism creates a novel IL-6-binding site, increasing the transcription and creating a loop of TLR9/IL-6 signalling amplification (Carvalho et al, 2011).…”