Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals

Fernandes, Marcos Tadeu Parron; Fernandes, Karen Barros Parron; Marquez, Audrey S.; Cólus, I.M.S.; Souza, Marilesia Ferreira de; Santos, João Paulo Manfré dos; Frederico, Regina Célia Poli

doi:10.1016/j.cyto.2015.07.020

Cited by 33 publications

(21 citation statements)

References 32 publications

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“…In comparison with the CC genotype, the IL-6 (-572G/C) G allele has been determined to be responsible for greater IL-6 production and higher serum level (26). Fernandes et al (10) reported that patients with the IL-6 (-572G/C) G allele had higher IL-6 levels than patients with the CC and CG genotypes, and the G allele was identified as a risk factor for the development of osteoarthritis. The relationship of this polymorphism with Type 2 diabetes was examined in a metaanalysis of 10 studies, which concluded that subjects with the GG genotype were at greater risk of developing the disease (27).…”

Section: Discussionmentioning

confidence: 99%

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Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

Akbulut

Çebi²,

Sağ³

et al. 2017

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

“…IL-6 (-572G/C) (rs1800796) is found adjacent to the IL-6 5' promoter region (8). Previous studies have determined that this allele is responsible for high serum IL-6 levels and that polymorphism has an effect on the development of allergic rhinitis, osteoarthritis, and ischemic heart disease and on the prognosis of breast cancer (9)(10)(11).…”

mentioning

confidence: 99%

Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

Akbulut

Çebi²,

Sağ³

et al. 2017

Turk J Gastroenterol

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“…IL-6, a multifunctional cytokine that regulates the immune response, has been intensively studied in the recent years (Fernandes et al, 2015). IL-6 is secreted by T cells and macrophages that are capable of inducing immune responses, including responses to trauma (Singh et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Zhu¹,

Li²,

Li³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated that when the IL-6 -572 CC homozygote genotype was used as the reference group, the GG genotype was found to be associated with a significantly increased risk of KS (GG vs CC: OR = 2.097, 95%CI = 1.100-3.995, P = 0.025). When the IL-6 -572 C allele was used as the reference group, the G allele was found to be associated with significantly increased risk of KS (G vs C: OR = 1.317, 95%CI = 1.002-1.730, P = 0.048). Furthermore, we observed a marked 2 X.J. Zhu et al. Genetics and Molecular Research 16 (2): gmr16029110 increase in serum IL-6 levels in KS patients with GG genotypes when compared to KS patients harboring the CC genotype. In conclusion, our results suggest that IL-6 gene polymorphism was associated with keloid scars in the southeastern Chinese Han population.

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“…21–26 However, IL- 6 as a multifunctional cytokine plays a key role in chronic inflammation and SNP rs1800796 is associated with susceptibility to several diseases including breast cancer 38,39 , osteoarthritis 40 and membranous glomerulopathy 41 . Furthermore, the sex disparity related to IL-6 polymorphisms is not limited to stroke but also influences susceptibility to other diseases.…”

Section: Discussionmentioning

confidence: 99%

Interleukin–6 ( IL-6 ) rs1800796 and cyclin dependent kinase inhibitor ( CDKN2A/CDKN2B ) rs2383207 are associated with ischemic stroke in indigenous West African Men

Akinyemi

Arnett

Tiwari

et al. 2017

Journal of the Neurological Sciences

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Background Inherited genetic variations offer a possible explanation for the observed peculiarities of stroke in sub – Saharan African populations. Interleukin–6 polymorphisms have been previously associated with ischemic stroke in some non-African populations. Aim Herein we investigated, for the first time, the association of genetic polymorphisms of IL-6 and CDKN2A- CDKN2B and other genes with ischemic stroke among indigenous West African participants in the Stroke Investigative Research and Education Network (SIREN) Study. Methods Twenty-three previously identified single nucleotide polymorphisms (SNPs) in 14 genes of relevance to the neurobiology of ischemic stroke were investigated. Logistic regression models adjusting for known cardiovascular disease risk factors were constructed to assess the associations of the 24 SNPs in rigorously phenotyped cases (N=429) of ischemic stroke (Men = 198; Women = 231) and stroke– free (N=483) controls (Men = 236; Women = 247). Results Interleukin-6 (IL6) rs1800796 (C minor allele; frequency: West Africans = 8.6%) was significantly associated with ischemic stroke in men (OR = 2.006, 95% CI = [1.065, 3.777], p = 0.031) with hypertension in the model but not in women. In addition, rs2383207 in CDKN2A/CDKN2B (minor allele A with frequency: West Africans = 1.7%) was also associated with ischemic stroke in men (OR = 2.550, 95% CI = [1.027, 6.331], p = 0.044) with primary covariates in the model, but not in women. Polymorphisms in other genes did not show significant association with ischemic stroke. Conclusion Polymorphisms rs1800796 in IL6 gene and rs2383207 in CDKN2A/CDKN2B gene have significant associations with ischemic stroke in indigenous West African men. CDKN2A/CDKN2B SNP rs2383207 is independently associated with ischemic stroke in indigenous West African men. Further research should focus on the contributions of inflammatory genes and other genetic polymorphisms, as well as the influence of sex on the neurobiology of stroke in people of African ancestry.

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Association of interleukin-6 gene polymorphism (rs1800796) with severity and functional status of osteoarthritis in elderly individuals

Cited by 33 publications

References 32 publications

Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Interleukin–6 ( IL-6 ) rs1800796 and cyclin dependent kinase inhibitor ( CDKN2A/CDKN2B ) rs2383207 are associated with ischemic stroke in indigenous West African Men

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