Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

Pigossi, Suzane Cristina; Alvim-Pereira, Fabiano; Alvim-Pereira, Cláudia Cristina; Trevilatto, Paula Cristina; Scarel‐Caminaga, Raquel Mantuaneli

doi:10.1097/id.0000000000000157

Cited by 12 publications

(48 citation statements)

References 49 publications

(26 reference statements)

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“…[14–16] The clinical success of dental implants is based on osseointegration, and any intense inflammatory response can stimulate the resorption of supporting bones and damage this process, leading to implant failure. [15–17] …”

Section: Introductionmentioning

confidence: 99%

Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk

Zeng²,

Weng³

et al. 2016

Medicine

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Background:Tumor necrosis factor-alpha (TNF-α) is a potent immune-inflammatory mediator involved in the regulation of bone resorption. The single nucleotide polymorphism G-308A in the TNF-α gene increases the level of this cytokine. This phenomenon is also related to several diseases. Although the association between TNF-α (G-308A) polymorphism and dental peri-implant disease has been investigated, results have remained controversial. Hence, we performed this meta-analysis to provide a comprehensive and systematic conclusion on this topic.Methods:We performed a systematic literature search in PubMed, Embase, ISI Web of Science, Cochrane Library, and Chinese National Knowledge Infrastructure until July 2015. A fixed-effect model was established to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). The calculated values were then used to assess the strength of the association between the TNF-α (G-308A) polymorphism and the dental peri-implant disease risk. The heterogeneity between included studies was evaluated with Cochran Q and I2 statistics. Interstudy publication bias was investigated with a funnel plot.Results:Six eligible studies were included in this meta-analysis. The pooled ORs did not reveal a significant relationship between the TNF-α (G-308A) polymorphism and the disease susceptibility. Subgroup analyses in terms of ethnicity and disease type yielded similar results.Conclusion:Our meta-analysis revealed that TNF-α (G-308A) polymorphism was not significantly associated with the risk of dental peri-implant disease. However, further studies with large sample sizes should be performed to verify these results.

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Section: Introductionmentioning

confidence: 99%

Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk

Zeng²,

Weng³

et al. 2016

Medicine

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“…Among these factors, the most studied are those related to the host, such as bone quantity and quality osteoporosis, smoking, presence of teeth plaque and calculus index, dental mobility general health condition and genetic factors . The suggestion, is that genetic background contributes to a better understanding of why some patients present dental implant failure without a clear clinical cause…”

Section: Discussionmentioning

confidence: 99%

“…Studies have already suggested a genetic contribution to dental implants loss. Losses without apparent clinical cause were attributed partially to genetic polymorphisms, which may influence the osseointegration process of dental implants . To the author's knowledge, there is no study with LTA , TNFA, and LTB genes and implant loss to date.…”

Section: Discussionmentioning

confidence: 99%

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Clinical aspects and polymorphisms in the LTA, TNFA, LTB genes and association with dental implant loss

Broker

Doetzer

Souza

et al. 2018

Clin Implant Dent Rel Res

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Background This study shows the relationship between host factors and environmental factors in the influence of susceptibility to loss of dental implants. Purpose The aim of this study was to investigate the association of clinical aspects and tag SNPs of the genes LTA, TNFA, and LTB with dental implant loss. Materials and Methods The subjects consisted of 244 patients, divided into two groups: control group (C)—163 individuals who did not lose any implants, being in function for at least 6 months; and study group (S)—81 individuals who had lost at least one implant. DNA was collected from saliva, and the genotypes were determined by real time PCR. Univariate and multivariate analysis were employed p < .05. Results After multivariate analysis, dental implant loss remained associated with the presence of teeth (p = .011), a larger amount of placed implants (p = .001), and allelle C of rs2009658 of the LTA gene (p = .006). For the other tag SNPs of these studied genes, there was no association between the groups C and S with dental implants loss. Conclusion Presence of teeth, number of placed implants and allele C of rs2009658 of LTA gene were associated with implant loss.

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“…Some single‐nucleotide polymorphism (SNPs) may affect gene expression levels and protein production or functions; consequently, they influence osteogenesis and inflammatory responses. Some SNPs in cytokines and lipid mediators genes were associated with implant loss and peri‐implantitis, explain some of interindividual risk factors …”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

Munhoz

Branco²,

Souza

et al. 2018

Clin Implant Dent Rel Res

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Background Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host response is influenced by genetic factors. Matrix metalloproteinases (MMPs) are enzymes that contribute to degradation and removal of collagen from extracellular matrix. Purpose This case‐control study aimed to investigate the haplotypic combination of MMP polymorphism (rs1144393, rs1799750, rs3025058, and rs11225395) and implant loss. Materials and Methods Two hundred nonsmokers subjects were matched by gender, age, implant number and position and divided in control group, 100 patients with one or more healthy implants, and test group, and 100 patients with one or more implant failures. Genomic DNA was extracted from saliva and genotypes were obtained by PCR‐RFLP. Results A significant association of rs1799750 (MMP‐1) and rs11225395 (MMP‐8) polymorphism on early implant loss was demonstrated (P ≤ 0.001). Global haplotype analysis indicated a significant difference between both groups (P < 0.0001). Haplotype T‐A‐GG‐5A‐C had a statistically significant risk effect, while haplotype C‐A‐G‐6A‐C andT‐G‐2G‐5A‐C had a protective effect in implant loss. Conclusions The results of this study showed that MMPs haplotype are a risk factor to early implant loss.

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Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

Abstract: The C allele of the +33 (C/T) polymorphism in the IL4 gene was associated with susceptibility to dental implant loss in Brazilians in the studied population.

Cited by 12 publications

References 49 publications

Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk

Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk

Clinical aspects and polymorphisms in the LTA, TNFA, LTB genes and association with dental implant loss

Matrix metalloproteinases gene polymorphism haplotype is a risk factor to implant loss: A case‐control study

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