Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus

Chong, Wai Po; Ip, W. K.; Wong, Wilfred Hing Sang; Lau, Chak Sing; Chan, TM; Lau, YL

doi:10.1038/sj.gene.6364119

Cited by 80 publications

(61 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lastly, proximal promoter IL-10 haplotypes have been shown to alter IL-10 secretion (46-48) and a specific haplotype containing IL-10 (À819T) has been associated with elevated IL-10 mRNA levels (47). IL-10 promoter haplotypes have been associated with progression of HIV infection, autoimmune diseases such as asthma, lupus erythematosus, graft-versus-host disease following marrow transplantation, and Alzheimer's disease (49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene

et al. 2005

View full text Add to dashboard Cite

Benzene is a recognized hematotoxin and leukemogen but its mechanism of action and the role of genetic susceptibility are still unclear. Cytokines, chemokines, and cellular adhesion molecules are soluble proteins that play an important regulatory role in hematopoiesis. We therefore hypothesized that variation in these genes could influence benzene-induced hematotoxicity. We analyzed common, well-studied singlenucleotide polymorphisms (SNPs) in 20 candidate genes drawn from these pathways in a study of 250 workers exposed to benzene and 140 unexposed controls in China. After accounting for multiple comparisons, SNPs in five genes were associated with a statistically significant decrease in total WBC counts among exposed workers [IL-1A (À889C>T), IL-4 (À1098T>G), IL-10 (À819T>C), IL-12A (8685G>A), and VCAM1 (À1591T>C)], and one SNP [CSF3 (Ex4À165C>T)] was associated with an increase in WBC counts. The adhesion molecule VCAM1 variant was particularly noteworthy as it was associated with a decrease in B cells, natural killer cells, CD4 + T cells, and monocytes. Further, VCAM1 (À1591T>C) and CSF3 (Ex4À165C>T) were associated, respectively, with decreased (P = 0.041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzeneinduced hematotoxicity. (Cancer Res 2005; 65(20): 9574-81)

show abstract

Section: Discussionmentioning

confidence: 99%

Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The frequency of G allele in our population (4%) was similar to that of Korean (7.4%) 22 and Japanese (6.5%), 23 but was significantly different from Caucasians (48%). 24 The G allele frequency in Cambodians is more like that in Caucasians than in other Asian populations, however, there are significant departures from the Hardy-Weinberg equilibrium in both their cases and controls. 20 Nevertheless, inconsistent results in association of IL-10 polymorphisms with TB may reflect ethnic-specific genetic variations, or suggest the possibility that other more distal promoter elements are involved.…”

Section: Association Of Ifn-c and Il-10 With Tuberculosismentioning

confidence: 99%

Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

et al. 2005

Self Cite

View full text Add to dashboard Cite

Interferon gamma (IFN-g) and interleukin 10 (IL-10) are believed to play opposing roles in host immunity against mycobacterial infection. IFN-g activates macrophages, while IL-10 downregulates the expression of T helper type 1 cytokines, MHC class II antigens and costimulatory molecules on macrophages. Associations of IFN-g À179 (G/T), þ 874 (A/T), þ 875 miscrosatellite CA repeats and þ 4766 (C/T), and IL-10 À1082 (A/G), À819 (C/T) and À592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population. The frequency of a low IFN-g-producing þ 874 A/A genotype was significantly over-represented in the patient group (Po0.001, OR ¼ 3.79, 95% CI ¼ 1.93-7.45). We identified 10 alleles in the IFN-g CA repeats and observed a significant difference in allele frequency distribution between patients and controls (Po0.001). By grouping alleles into 12 and non-12 CA repeats, the non-12/non-12 genotype yielded a similar significant result (Po0.001, OR ¼ 4.56, 95% CI ¼ 2.21-9.43) as observed in þ 874 A/A genotype. Weak associations of the IL-10 GCC/À genotype (P ¼ 0.04) and the low IFN-g-producing A/A genotype (P ¼ 0.06) with TB relapse/extrapulmonary cases were found. This study suggests the possible role of interferon gamma in TB susceptibility.

show abstract

“…4,5 A number of susceptibility genes, such as HLA, mannose-binding lectin gene, C4A, FcgR, tumor-necrosis factor-a (TNF-a), programmed cell death 1 gene (PDCD1) and interleukin-10 (IL-10), have been associated with SLE among various populations. [6][7][8][9][10][11] IL-10 is a pleiotropic cytokine produced by both T/B cells and macrophages and possesses both anti-inflammatory and immunosuppressive properties. 12 Investigations in numerous inflammatory disease models including chronic enterocholitis, cutaneous inflammatory condition, endotoxic shock and Shwartzman reaction, and autoimmune encephalomyelitis in IL-10-deficient mice have yielded strong evidence that IL-10 plays a central role in vivo in restricting inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1

et al. 2007

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease characterized by the dysregulation of T and B cells that leads to hyperactivity of B cells and production of autoantibodies, and involves both environmental and genetic factors. Interleukin-10 (IL-10) is a candidate susceptibility gene in SLE. In particular, three IL-10 promoter singlenucleotide polymorphisms (SNPs; À1082A/G, À819T/C and À592A/C) are strongly associated with the pathogenesis of SLE. We found that the homozygous GCC haplotype linked to greater SLE severity confers higher IL-10 gene transcriptional activity than the ATA haplotype in macrophages that encounter apoptotic cells, because of the differential DNA binding to the À592 SNP by a nuclear protein uniquely induced by apoptotic cells. We identified this protein as poly(ADP-ribose) polymerase-1, confirmed its physiological role and characterized its molecular properties in modulating IL-10 production during phagocytosis of apoptotic cells. This study unveils a novel direct link between DNA damage repair/apoptosis pathways and IL-10-mediated immune regulation.

show abstract

Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus

Cited by 80 publications

References 48 publications

Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene

Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene

Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1

Contact Info

Product

Resources

About