Association of intercellular adhesion molecule-1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still's disease

Chen, Der‐Yuan; Lan, Joung‐Liang; Lin, Fang‐Ju; Hsieh, Tsu‐Yi

doi:10.1002/art.21164

Cited by 55 publications

(30 citation statements)

References 49 publications

(72 reference statements)

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“…Interestingly, serum CXCL9, CXCL10 and CXCL11 were significantly higher in AOSD patients with RHS than in patients without RHS, although the number of RHS patients was small, and serum IFN-γ levels were not different between them. Our results could be interpreted in the same context as previous data related to IL-18 in AOSD722. IL-18, a member of the IL-1 family and a well-known IFN-γ–inducing cytokine, promotes Th1 cytokine production23.…”

Section: Discussionsupporting

confidence: 83%

Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease

Han

Suh

Jung

et al. 2017

Sci Rep

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C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 are produced in response to interferon-γ (IFN-γ) and trigger inflammation with the accumulation of activated lymphocytes. It appears that these chemokines could play a role in the pathogenesis of adult-onset Still’s disease (AOSD). Therefore, we investigated the associations between the levels of these chemokine and clinical manifestations in patients with active AOSD. Serum levels of IFN-γ, CXCL9, CXCL10 and CXCL11 were determined using enzyme-linked immunosorbent assays. IFN-γ levels were higher in AOSD patients than in rheumatoid arthritis (RA) patients (p = 0.001) or healthy controls (HCs) (p = 0.032). AOSD patients also exhibited higher levels of CXCL9, CXCL10, and CXCL11 compared with RA patients (p < 0.001) and HCs (p < 0.001). In follow-up AOSD patients after treatment with corticosteroid, the levels of CXCL9, CXCL10 and CXCL11 fell significantly, whereas IFN-γ levels were not significantly different. On immunohistochemistry, the percentage of CXCL10-positive inflammatory cells was higher in skin biopsy samples from AOSD patients than in those from normal control (p = 0.012), eczema (p = 0.019), and psoriasis (p = 0.009) groups. Levels of the IFN-γ–induced chemokines, CXCL9, CXCL10 and CXCL11, were elevated and correlated with several disease activity markers. These interferon-γ–induced chemokines may contribute to inflammatory responses and skin manifestations in AOSD.

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Section: Discussionsupporting

confidence: 83%

Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease

Han

Suh

Jung

et al. 2017

Sci Rep

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“…Furthermore, IL-18 can drive angiogenesis [12] and the production of chemokines, it can upregulate the expression of costimulatory molecules as CD40 and CD40L, and, finally, it can provoke tissue damage through the activation of cell-mediated cytotoxicity and the stimulation of the release of metalloproteases [7]. It is also responsible of an increased expression of the intercellular adhesion molecule-1 (ICAM-1) by endothelial cells, representing a possible predictor of disseminated intravascular coagulation [13]. Moreover, a recent study has proposed a proapoptotic role for IL-18 that has been associated with the induction of an increased expression of FasL and p53 on autoreactive lymphocytes in AOSD [14].…”

Section: Discussionmentioning

confidence: 99%

IL-18 Serum Level in Adult Onset Still’s Disease: A Marker of Disease Activity

Colafrancesco

Priori

Alessandri

et al. 2012

International Journal of Inflammation

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Introduction. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process. Objective. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity. Methods. IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD. Disease activity was assessed using Pouchot's criteria. As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated. Results. IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (P = 0.001) and control groups (RA P = 0.0070, SS P = 0.0029, SLE P = 0.0032, NHS P = 0.0004). A significant correlation between IL-18 serum levels and disease activity (P < 0.0001), and laboratory parameters as ferritin (P = 0.0127) and C-reactive protein (P = 0.0032) was demonstrated. Conclusions. Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features. ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD. This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD.

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“…However, it is difficult to differentiate liver dysfunction due to AOSD itself from drug-induced liver dysfunction. Recently, Chen et al determined soluble intercellular adhesion molecule 1 (sICAM-1) in patients with active untreated AOSD and identified serum sICAM-1 level as a predictor of liver dysfunction in AOSD, and serum sICAM-1 levels were significantly correlated with disease activity and serum ferritin levels which have been also reported to be suitable for monitoring AOSD disease activity [13]. In our subject, in spite of decrease in serum CRP and ferritin levels, serum AST and ALT levels were increased by NSAIDs and were promptly decreased by corticosteroid, suggesting the presence of drug-induced liver dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease

Yanai

Furutani

Yoshida

et al. 2009

Case Reports in Medicine

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Although hepatic dysfunction is common in adult-onset Still's disease (AOSD), sometimes it is difficult to differentiate hepatic dysfunction due to AOSD itself from drug-induced hepatic dysfunction. Further, myalgia often occurs in patients with AOSD; however, AOSD patients complicated with myositis are rare. We report a 43-year-old Japanese man with AOSD who developed myositis and hepatic dysfunction which were deteriorated by multiple nonsteroidal antiinflammatory drugs (NSAIDs) and were dramatically ameliorated by a low-dose steroid therapy. A skin biopsy of salmon pink rash which is characteristic for AOSD showed leukocytoclastic vasculitis, and the markers for vasculitis, plasma von Willebrand factor, and vascular endothelial growth factor levels were elevated in this patient, suggesting an association between AOSD and systemic vasculitis.

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Association of intercellular adhesion molecule-1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still's disease

Cited by 55 publications

References 49 publications

Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease

Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease

IL-18 Serum Level in Adult Onset Still’s Disease: A Marker of Disease Activity

Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease

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