Association of Insulinoma and Type 2 Diabetes Mellitus

Abstract

The association of diabetes mellitus and insulinoma is unusual. We are reporting the case of a 58 years old patient having diabetes mellitus type 2 for several years. This patient was well balanced with oral anti-diabetic treatment. However, the diagnosis of insulinoma was discussed due to recent episodes of hypoglycemia that persisted even after stopping the treatment. Abdominal CT allowed the topographic diagnosis. The patient underwent a caudal pancreatectomy. Furthermore, the postoperative period shows that the diabetes mellitus requires the oral anti-diabetic treatment and basal insulin have to be stable. Then, the occurrence of hypoglycemia in the diabetic mellitus type 2 and, especially the persistence after discontinuation of therapy, suggest the unusual diagnosis of insulinoma as illustrated in our observation.

Metastatic insulinoma presenting after bariatric surgery in a patient diagnosed with MEN1

“… 1 , 16 It is conceivable that our patient's prior history of type 2 DM might have masked her symptoms; however, case reports of patients presenting with DM and insulinomas have been described with new‐onset recurrent hypoglycemia not attributable to diabetic medications. 17 , 18 , 19 , 20 …”

“…1,16 It is conceivable that our patient's prior history of type 2 DM might have masked her symptoms; however, case reports of patients presenting with DM and insulinomas have been described with new-onset recurrent hypoglycemia not attributable to diabetic medications. [17][18][19][20] The main treatment for insulinomas is surgery when possible but medical therapies are available when surgery is inappropriate or ineffective. Benign insulinomas carry an excellent prognosis after surgical resection.…”

Challenge of coexisting type 2 diabetes mellitus and insulinoma: a case report

“…The coexistence of insulinoma and diabetes is so rare that there are only a few published case reports. In addition, there has been a case of insulinoma in which, despite stopping sulfonylureas, hypoglycemic episodes persisted [ 1 ]. We report a rare case of insulinoma in a 54-year-old man with pre-existing type 2 diabetes mellitus and a significant family history of diabetes.…”

Hypo- and hyperglycemia: how to balance it?

“…Инсулинома относится к редким нейроэндокринным опухолям, в подавляющем большинстве случаев она расположена в поджелудочной железе, в 90% наблюдений опухоль солитарная и доброкачественная [4].…”