Association of Insulin Resistance with Vascular Ageing in a General Caucasian Population: An EVA Study

Gómez‐Sánchez, Leticia; Gómez‐Sánchez, Marta; Lugones-Sánchez, Cristina; Tamayo-Morales, Olaya; González-Sánchez, Susana; Rodríguez‐Sánchez, Emiliano; Gómez‐Marcos, Manuel A.; Investigators, On Behalf Of The Eva

doi:10.3390/jcm10245748

Cited by 4 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The insulin signaling has effects on metabolic health and can be targeted to improve the insulin sensitivity in T2DM, obesity, and other metabolic diseases. 25 Previous studies have reported that constitutively active HSF1 in pancreatic islets enhances glucose-induced insulin secretion. Therefore, identification of the molecular mechanisms underlying the effects of HSF1 on muscle glucose utilization is of significant interest.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization

Lin

et al. 2022

The FASEB Journal

View full text Add to dashboard Cite

The regulation of muscle glucose utilization has significant potential for the treatment of type 2 diabetes mellitus (T2DM) and obesity. Heat shock factor 1 (HSF1) is involved in cellular metabolism and regulation of muscle metabolism. However, it is unclear how HSF1 regulates muscle glucose metabolism. In the present study, the development of obesity in mice was associated with HSF1 downregulation. Serum samples and muscle biopsies were obtained from obese and healthy humans. Fasting glucose and insulin levels and the homeostasis model assessment of insulin resistance value showed that obesity was associated with insulin resistance. The skeletal muscle level of HSF1 was decreased in obese and ob/ob mice. HSF1 was selectively over-expressed in the skeletal muscles of high fat diet (HFD)-fed mice. Muscle HSF1 over-expression successfully triggered glycolytic-to-oxidative myofiber switch and increased fatty acid metabolism and insulin sensitivity in the skeletal muscles of HFD-fed mice. Moreover, HSF1 improved energy expenditure and blocked muscle accumulation of triglycerides in HFD-fed mice. Consequently, muscle HSF1 mitigated the impaired muscle insulin signaling and insulin resistance in HFD-fed mice. In conclusion, T2DM and obesity in HFD-fed mice may be treated with selective HSF1-directed programming of exercise-like effects in skeletal muscle. These findings may aid the development of a new therapeutic approach for obesity and T2DM.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The insulin signaling pathway has beneficial effects on metabolic health and can be targeted to improve the insulin sensitivity in T2DM, obesity, and other metabolic diseases 25 . Previous studies have reported that constitutively active HSF1 in pancreatic islets enhances glucose‐induced insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization

Lin

et al. 2022

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…The carotid stiffness parameters increase is positively correlated with the increase of fasting glucose, insulin, glycated hemoglobin A1c, HOMA-insulin resistance index, waist circumference, triglycerides, and decrease of high-density lipoprotein cholesterol (Gomez-Sanchez et al 2021). A recent study in adult persons without CVD has demonstrated direct association of carotid-femoral pulse wave velocity with HOMA-insulin resistance index and an inverse relationship with telomere length.…”

Section: Discussionmentioning

confidence: 93%

Pathophysiological and clinical aspects of the circadian rhythm of arterial stiffness in diabetes mellitus: A minireview

Serhiyenko

Sehin³

et al. 2022

Endocrine Regulations

View full text Add to dashboard Cite

Several cross-sectional trials have revealed increased arterial stiffness connected with the cardiac autonomic neuropathy in types 2 and 1 diabetic patients. The pathophysiological relationship between arterial stiffness and autonomic dysfunction in diabetes mellitus is still underinvestigated and the question whether the presence of cardiac autonomic neuropathy leads to arterial stiffening or increased arterial stiffness induced autonomic nervous system impairment is still open. Both arterial stiffness and dysfunction of the autonomic nervous system have common pathogenetic pathways, counting state of the chronic hyperinsulinemia and hyperglycemia, increased formation of advanced glycation end products, activation of protein kinase C, development of endothelial dysfunction, and chronic low-grade inflammation. Baroreceptor dysfunction is thought to be one of the possible reasons for the arterial wall stiffening development and progression. On the contrary, violated autonomic nervous system function can affect the vascular tone and by this way alter the large arteries walls elastic properties. Another possible mechanism of attachment and/or development of arterial stiffness is the increased heart rate and autonomic dysfunction corresponding progression. This minireview analyzes the current state of the relationship between the diabetes mellitus and the arterial stiffness. Particular attention is paid to the analysis, interpretation, and application of the results obtained in patients with type 2 diabetes mellitus and diabetic cardiac autonomic neuropathy.

show abstract

“…Sensitivity analyses were conducted with the standard for arterial stiffness of 1400 cm/s. Additionally, we explored the relationships between TG/HDL-C and TyG with healthy vascular aging (HVA), normal vascular aging (NVA), and early vascular aging (EVA), defined as < baPWV-percentile < 10th, 10th ≤ baPWV-percentile ≤ 90th, and baPWVpercentile > 90th of the population stratified by age and sex [29]. SAS v9.4 was taken for all analyses (SAS Institute Inc., Cary, NC, USA), with a two-sided P value < 0.05 considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride–glucose index with arterial stiffness risk

Zhang,

Huo,

et al. 2024

Lipids Health Dis

View full text Add to dashboard Cite

Background The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are novel indexes for insulin resistance (IR). We aimed to evaluate associations of TG/HDL-C and TyG with arterial stiffness risk. Methods We enrolled 1979 participants from the Rural Chinese Cohort Study, examining arterial stiffness by brachial-ankle pulse wave velocity (baPWV). Logistic and linear regression models were employed to calculate effect estimates. For meta-analysis, we searched relevant articles from PubMed, Embase and Web of Science up to August 26, 2023. The fixed-effects or random-effects models were used to calculate the pooled estimates. We evaluated dose-response associations using restricted cubic splines. Results For cross-sectional studies, the adjusted ORs (95%CIs) for arterial stiffness were 1.12 (1.01–1.23) and 1.78 (1.38–2.30) for per 1 unit increment in TG/HDL-C and TyG. In the meta-analysis, the pooled ORs (95% CIs) were 1.26 (1.14–1.39) and 1.57 (1.36–1.82) for per 1 unit increment of TG/HDL-C and TyG. Additionally, both TG/HDL-C and TyG were positively related to PWV, with β of 0.09 (95% CI 0.04–0.14) and 0.57 (95% CI 0.35–0.78) m/s. We also found linear associations of TG/HDL-C and TyG with arterial stiffness risk. Conclusions High TG/HDL-C and TyG were related to increased arterial stiffness risk, indicating TG/HDL-C and TyG may be convincing predictors of arterial stiffness.

show abstract

Association of Insulin Resistance with Vascular Ageing in a General Caucasian Population: An EVA Study

Cited by 4 publications

References 55 publications

Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization

Skeletal muscle HSF1 prevents insulin resistance by improving glucose utilization

Pathophysiological and clinical aspects of the circadian rhythm of arterial stiffness in diabetes mellitus: A minireview

Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride–glucose index with arterial stiffness risk

Contact Info

Product

Resources

About