Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study

Wang, Tiange; Lu, Jieli; Shi, Lixin; Chen, Gang; Xu, Min; Xu, Yu; Su, Qing; Mu, Yiming; Chen, Lulu; Hu, Ruying; Tang, Xulei; Yu, Xuefeng; Li, Mian; Zhao, Zhiyun; Chen, Yuhong; Yan, Li; Qin, Guijun; Wan, Qin; Dai, Meng; Zhang, Di; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Qin, Yingfen; Chen, Li; Huo, Yanan; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Hongkui; Zhao, Jiajun; Lai, Shenghan; Bi, Yufang; DeFronzo, Ralph A.; Wang, Weiqing; Ning, Guang; Disease, China Cardiometabolic

doi:10.1016/s2213-8587(19)30425-5

Cited by 157 publications

(128 citation statements)

References 27 publications

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“…However, due to its invasiveness, complexity, and time consuming properties, HEC is difficult to use in clinical practice. As an alternative strategy, the homeostasis model assessment for the IR (HOMA-IR) index is much simpler than HEC [ 28 ]. However, insulin testing still needs to consider the cost and repeatability issues, especially in primary health institutions [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population

Meng

et al. 2020

International Journal of Endocrinology

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Background. Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. Thus, we conducted this longitudinal study to examine the relation of triglyceride-glucose index (TyG), a simple noninsulin-based IR assessment tool, and its derivatives with the risk of HUA. Methods. A total of 42,387 adults who received routine health screening and were free of HUA were included for the longitudinal analyses. TyG, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) were calculated through anthropometric and biochemical indicators. Associations of TyG, TyG-BMI, TyG-WC, and TyG-WHtR with HUA risk were estimated using Cox regression analyses. Results. The incident cases of HUA occurred in 4,230 subjects during the 138,163 person-years of observation, and the crude incidence rate of HUA was 30.6 per 1000 person-years. After multivariate adjustment, we observed an increased risk for incident HUA for the upper TyG and its derivatives’ tercile. The HRs of TyG were greater than that of its components in both sexes. Compared with TyG, TyG-related parameters only had higher HRs in women but not in men. Conclusions. TyG and its integration with obesity indicators have the potential to help risk stratification and prevention of HUA, especially among women.

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Section: Discussionmentioning

confidence: 99%

Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population

Meng

et al. 2020

International Journal of Endocrinology

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“…Insulin resistance (IR) is a major pathophysiological pathway of type 2 diabetes development and may appear about two decades prior to the formal diagnosis (4,5). A recent study indicated that IR was more closely associated with the risk of incident diabetes among Chinese adults than β-cell dysfunction, which is another pivotal pathological feature of diabetes (6). Additionally, in the past four decades, China has experienced disruptive transitions of dietary patterns and has witnessed a massive rise in with the rate of obesity, which is major factor for the progression of IR (7,8).…”

Section: Introductionmentioning

confidence: 99%

Association Between Triglyceride Glucose Index and Risk of New-Onset Diabetes Among Chinese Adults: Findings From the China Health and Retirement Longitudinal Study

Chen

Liu

et al. 2020

Front. Cardiovasc. Med.

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The triglyceride glucose (TyG) index has been proposed to be a surrogate of insulin resistance. In the present study, we aimed to examine the relationship between TyG index and the risk of incident diabetes in middle-age and older adults in China using nationally representative data from the China Health and Retirement Longitudinal Study 2011–2015. Information on socio-demographics, medical background, anthropometric measurement, and laboratory information were collected. The association between TyG index and diabetes was examined by Cox proportional hazards models and restricted cubic spline regression, and the results were presented in hazard ratio (HR) with 95% confidence interval (CI). Subgroup analyses were also conducted to examine potential interactions between demographics and TyG index. Among 7,428 participants, 791 (10.6%) of them developed diabetes over 3.4 years of follow-up. The multivariate HR for every SD increment in TyG index was 1.22 (95% CI, 1.14–1.31). When comparing to the lowest quartile of TyG index, the multivariate HRs for new-onset diabetes were 1.22 (0.96–1.54) for Q2, 1.61 (1.28–2.01) for Q3, and 1.73 (1.38–2.16) for Q4 (P for trend <0.001). The restricted cubic spline regression also showed a linear association. No interaction was found between subgroup variables and the association between TyG index and the risk of diabetes. In conclusion, higher TyG index associated with the elevated risk of new-onset diabetes in middle-aged and older adults.

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“…It is now generally accepted that IR and progressive damage to islet cell function are the fundamental pathological mechanisms of T2DM (Li et al, 2014). IR is often the first pathological manifestation of T2DM and accompanies the entire disease process (Kim et al, 2019;Wang et al, 2020). Before the diagnosis of T2DM, patients often have long-term IR, and the body compensates by secreting more insulin.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus

et al. 2020

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Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a global public health problem. Studies on T2DM prevention and treatment mostly focus on discovering therapeutic drugs. Artemisinin and its derivatives were originally used as antimalarial treatments. In recent years, the roles of artemisinins in T2DM have attracted much attention. Artemisinin treatments not only attenuate insulin resistance and restore islet ß-cell function in T2DM but also have potential therapeutic effects on diabetic complications, including diabetic kidney disease, cognitive impairment, diabetic retinopathy, and diabetic cardiovascular disease. Many in vitro and in vivo experiments have confirmed the therapeutic utility of artemisinin and its derivatives on T2DM, but no article has systematically demonstrated the specific role artemisinin plays in the treatment of T2DM. This review summarizes the potential therapeutic effects and mechanism of artemisinin and its derivatives in T2DM and associated complications, providing a reference for subsequent related research.

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Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study

Cited by 157 publications

References 27 publications

Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population

Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population

Association Between Triglyceride Glucose Index and Risk of New-Onset Diabetes Among Chinese Adults: Findings From the China Health and Retirement Longitudinal Study

The Potential Roles of Artemisinin and Its Derivatives in the Treatment of Type 2 Diabetes Mellitus

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