Association Of Insulin Receptor Substrate-2 Gene Polymorphism With Ovarian Cancer

Çayan, Filiz; Gen, Ramazan; Ateş, Nurcan Aras; Ayaz, Lokman; Akbay, Esen; Dılek, Saffet

doi:10.5174/tutfd.2009.03134.1

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…For healthy control groups, Cayan et al . [ 24 ] specified that the IRS-2 G allele frequency was 0.729, and D allele frequency was 0.271 in a Turkish population, whereas our control results were 0.662 and 0.338, respectively.…”

Section: Discussioncontrasting

confidence: 75%

“…Recently, Cayan et al . [ 24 ] examined the association of IRS-2 gene polymorphism with ovarian cancer in 185 Turkish women and found the GG genotype to be 53.6%; GD 38.6% and DD 7.9% in the control group, whereas our control results were 44.7%, 43.1% and 12.2%, respectively.…”

Section: Discussionmentioning

confidence: 78%

“…The gene polymorphisms coding the IRS proteins were comprehensively studied by means of diseases such as polycystic ovary syndrome [ 19 ], obesity [ 20 ], type 2 diabetes [ 21 ], prostate cancer [ 22 ], breast cancer [ 8 ], gastric cancer [ 23 ], ovarian cancer [ 24 ] and colon cancer [ 14 , 25 , 26 ]. Tumour size, lymph nodes and metastasis are widely examined in cancer research studies; however, only specific genes that are known to play a role in tumour initiation, progression and metastasis are analysed to identify the relevance of tumour characteristics.…”

Section: Discussionmentioning

confidence: 99%

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IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer

Yükseloğlu¹,

Çelik²,

Kucuk³

et al. 2014

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IntroductionGene polymorphisms have a broad range of analysis, but are of particular use in molecular medicine due to their potential in revealing the genetic tendency in diseases such as cancer, heart attack etc. These studies basically depend on mutations that can be detected by proper techniques. The genes coding the insulin receptor substrate (IRS) proteins are among the most widely analysed polymorphisms in various cancer types, in which a G1057D mutation is seen.AimTo determine the risk of colon cancer by analysing the IRS-2 gene polymorphism in Turkish patients.Material and methodsA total of 161 newly diagnosed colorectal cancer patients were analysed and compared to 197 unrelated healthy controls. A polymerase chain reaction-based restriction fragment length polymorphism method was carried out.ResultsNo differences were observed between the patient and control groups for both allele and genotype frequencies of the IRS-2 G1057D gene.ConclusionsOur results demonstrated that IRS-2 G1057D polymorphism is not associated with colorectal cancer in the Turkish population. This research is a preliminary and original study in Turkish patients with colorectal cancer. It also provides population-level genetic data on IRS-2 in the Turkish population. Further studies should be performed on larger number of patients and controls for more reliable results about the genetic tendency in colorectal cancer in Turkey. The study is a collaborative work of different universities and scientists.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer

Yükseloğlu¹,

Çelik²,

Kucuk³

et al. 2014

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“…Until now, about 3644 single nucleotide polymorphisms (SNP) in the IRS1 gene and 1704 SNP in the IRS2 gene have been reported ( http://www.ncbi.nlm.nih.gov/SNP ), some of which have been shown as susceptible loci for several kinds of diseases, such as cancer and Type 2 diabetes mellitus (T2DM) [15] – [19] . For example, an important IRS1 polymorphism rs1801278 (G>A) has been extensively investigated as a determinant of insulin resistance and a meta-analysis demonstrated that the A carriers significantly increased the risk of T2DM in those subjects whose mean age at diagnosis was less than 45 years [15] , [17] .…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Insulin Receptor Substrate2 rs1805097 Polymorphism and the Risk of Colorectal and Breast Cancer: A Meta-Analysis

Zhou

Zhang

et al. 2014

PLoS ONE

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BackgroundInsulin receptor substrate-2 (IRS-2), a signaling adaptor protein, was involved in two cancer-related pathways (the phosphatidylinositol 3′-kinase (PI3K) and the extracellular signal-regulated kinase (ERK) pathways). Several studies have evaluated the association between IRS2 rs1805097 (G>A) polymorphisms and the risk of colorectal and breast cancer. However, the results were inconsistent.Methodology/Principal FindingsA meta-analysis of seven published case-control studies (4 studies with 4798 cases and 5478 controls for colorectal cancer and 3 studies with 2108 cases and 2507 controls for breast cancer) were conducted to assess the strength of association using crude odd ratios (ORs) with 95% confidence intervals (CIs). For colorectal cancer, no obvious associations were found for all genetic models (homozygote comparison OR = 0.96, 95%CI 0.85–1.08, Pheterogeneity = 0.97; heterozygote comparison: OR = 0.91, 95%CI 0.73–1.13, Pheterogeneity<0.01; dominant model: OR = 0.92, 95%CI 0.80–1.06, Pheterogeneity = 0.05; recessive model: OR = 1.02, 95%CI 0.91–1.14, Pheterogeneity = 0.60). In the subgroup analysis by ethnicity, control source and consistency of frequency with Hardy-Weinberg equilibrium (HWE), still no significant associations were observed. For breast cancer, also no obvious associations were found for all genetic models (homozygote comparison: OR = 0.95, 95%CI 0.71–1.26, Pheterogeneity = 0.10; heterozygote comparison: OR = 1.00, 95%CI 0.89–1.14, Pheterogeneity = 0.71; dominant model: OR = 0.98, 95%CI 0.87–1.10, Pheterogeneity = 0.55; recessive model: OR = 0.95, 95%CI 0.72–1.25, Pheterogeneity = 0.07). We performed subgroup analyses by sample size and did not find an association.ConclusionsThis meta-analysis indicated that IRS2 rs1805097polymorphism was not associated with colorectal and breast cancer risk.

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“…Yukseloglu et al did not observe significant association between colorectal cancer and IRS2 Gly1057Asp variant in Turkish population (Yukseloglu et al, 2014). In the same population, Cayan et al showed that IRS2 1057Asp allele twofold increased risk for the development of endometrium cancer while they did not find any significant linked between this variant and ovarian cancer (Cayan et al, 2010;Cayan et al, 2011). Another study in Polish familial breast cancer cases also found no association between IRS2 Gly0157Asp and breast cancer development (Wagner et al, 2004).…”

Section: Discussionmentioning

confidence: 98%

No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

Gülaçar¹,

Kaya²,

Almalı³

et al. 2021

Van Sağlık Bilimleri Dergisi

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Bu çalışmanın amacı IRS2 Gly1057Asp varyantı ile özofagus kanseri yatkınlığı arasındaki ilişkiyi ortaya çıkarmaktır. Materyal ve Metot: Çalışma 70 özofagus kanseri ve 100 sağlıklı kontrol örneğini içeren vaka-kontrol çalışmasıdır. Genomik DNA, periferal kandan izole edilmiş olup, gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) temelli SNP genotipleme için ticari olarak dizayn edilmiş Taqman assay kullanılmıştır. Bulgular: Genotip dağılımında hasta ve kontrol örnekler arasında anlamlı bir farklılık saptanmamıştır. Sonuç: IRS2 Gly1057Asp varyantı ile özofagus kanser gelişim riski arasında anlamlı bir ilişki belirlenememiştir.

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Association Of Insulin Receptor Substrate-2 Gene Polymorphism With Ovarian Cancer

Cited by 4 publications

References 22 publications

IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer

IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer

Lack of Association between Insulin Receptor Substrate2 rs1805097 Polymorphism and the Risk of Colorectal and Breast Cancer: A Meta-Analysis

No Association Between IRS2 Gly1057Asp Polymorphism and Esophageal Cancer

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