Association of Insulin‐Like Growth Factor‐I with Body Composition, Weight History, and Past Health Behaviors in the Very Old: The Framingham Heart Study

Harris, Tamara B.; Kiel, Douglas P.; Roubenoff, Ronenn; Langlois, Jean; Hannan, Marian T.; Havlik, Richard J.; Wilson, Peter W.F.

doi:10.1111/j.1532-5415.1997.tb04497.x

Cited by 88 publications

(65 citation statements)

References 23 publications

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“…A significant positive relationship has been shown between low plasma IGF1 and functional outcome, such as impaired physical performance and self-reported difficulties with mobility tasks (10,32,33). However, physical performance has also been found to be negatively associated with IGF1 serum levels (13,35,(43)(44)(45). Our findings regarding functional performance and ADL disability are also conflicting with higher IGF1 serum levels being associated with slower walking speed in oldest-old men and a positive association between serum levels of IGFBP3 and ADL in oldest-old women.…”

Section: Discussionmentioning

confidence: 95%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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Objective: In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged-and oldest-old subjects. Design: Cross-sectional analysis in two different cohorts composed of middle-aged-(nZ672, mean 63.9G6.7 years) and oldest-old subjects (nZ272, all 89 years). Methods: Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately. Results: IGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged-and oldest-old women (both, P!0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldestold men (PZ0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (PZ0.002). Conclusion: The significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

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Section: Discussionmentioning

confidence: 95%

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Taekema¹,

Ling²,

Blauw³

et al. 2011

European Journal of Endocrinology

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“…However, subgroup analysis by gender revealed that IGF-1 was associated with sarcopenia only in women, with similar levels being observed in sarcopenic and non-sarcopenic male subjects, although subsequent multiple regression models suggested that the observed influence of IGF-1 in women was largely driven by the effect of age. The gender-specific association between body composition and IGF-1 has been contradictory (Payette et al 2003;Hofmann et al 2015; Goodman-Gruen and Barrett-Connor 1997; Harris et al 1997) . Contrary to the earlier studies that had defined sarcopenia based simply on muscle mass measurements, we had incorporated performance-based measures in defining sarcopenia, and our observed sex-specific influence of IGF-1, albeit not fulfilling statistical significance in the multiple regression models, is in line with an earlier study demonstrating correlation between muscle power and IGF-1 in older women but not in men (Kostka et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

135

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With considerable variation including potential sex-specific differential rate of skeletal muscle loss, identifying modifiable factors for sarcopenia will be pivotal to guide targeted interventions. This study seeks to identify clinical and biological correlates of sarcopenia in community-dwelling older adults, with emphasis on the role of anabolic and catabolic stimuli, and special reference to gender specificity. In this crosssectional study involving 200 community-dwelling and functionally independent older adults aged ≥50 years, sarcopenia was defined using the Asian Working Group for Sarcopenia criteria. Comorbidities, cognitive and functional performance, physical activity and nutritional status were routinely assessed. Biochemical parameters included haematological indices, lipid panel, vitamin D level, anabolic hormones [insulin-like growth factor-1 (IGF-1), free testosterone (males only)] and catabolic markers [inflammatory markers (interleukin-6, Creactive protein) and myostatin]. Multiple logistic regression was performed to identify independent predictors for sarcopenia. Age was associated with sarcopenia in both genders. Malnutrition conferred significantly higher odds for sarcopenia in women (OR=5.71, 95 % CI 1.13-28.84.44, p=0.035) while higher but acceptable range serum triglyceride was protective in men (OR=0.05, 95 % CI 0.00-0.52, p=0.012). Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR=1.11, 95 % CI 1.00-1.24, p=0.041). Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p=0.095). Our findings support differential pathophysiological mechanisms for sarcopenia that, if corroborated, may have clinical utility in guiding sex-specific targeted interventions for community-dwelling older adults.

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“…However, findings of studies on obese subjects are conflicting, with serum concentrations of total IGF-I reported to be relatively low, 13-16 unchanged 17,18 or increased. 19,20 Several crosssectional studies of adiposity and circulating IGF-I have found no relationship [21][22][23][24][25][26][27][28][29][30][31][32] while a nonlinear relationship of body mass index (BMI) with IGF-I has been observed in some large studies. [33][34][35][36] The data on the relationship between IGFBP-3, the main binding protein of IGF-1, and obesity are not consistent.…”

Section: Introductionmentioning

confidence: 99%

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

et al. 2006

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Objective: To examine the relationship between body mass index (BMI) and waist-hip ratio (WHR) with serum levels of insulinlike growth factor-I (IGF-I), and its binding protein (IGFBP)-3. Design: Cross-sectional study on 2139 women participating in a case-control study on breast cancer and endogenous hormones. Data on lifestyle and reproductive factors were collected by means of questionnaires. Body height, weight, waist and hip circumferences were measured. Serum levels of IGF-I and insulin-like binding protein (IGFBP)-3 were measured by enzymelinked immunosorbent assays. Adjusted mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist circumference, and WHR were calculated by linear regression. Results were adjusted for potential confounders associated with IGF-I and IGFBP-3. Results: Adjusted mean serum IGF-I values were lower in women with BMIo22.5 kg/m 2 or BMI429.2 kg/m 2 compared to women with BMI within this range (P heterogeneity o0.0001, P trend ¼ 0.35). Insulin-like growth factor-I was not related to WHR after adjustment for BMI. IGF-binding protein-3 was linearly positively related to waist and WHR after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear relation with BMI and a linear inverse relationship with WHR (P trend ¼ 0.005). Conclusions: Our data confirm the nonlinear relationship of circulating IGF-I to total adiposity in women. Serum IGFBP-3 was positively related to central adiposity. These suggest that bioavailable IGF-I levels could be lower in obese compared to nonobese women and inversely related to central adiposity.

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Association of Insulin‐Like Growth Factor‐I with Body Composition, Weight History, and Past Health Behaviors in the Very Old: The Framingham Heart Study

Cited by 88 publications

References 23 publications

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

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