Association of insulin-like growth factor binding protein-7 promoter methylation with esophageal cancer in peripheral blood

Association BetweenCYP1A1Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study

“…Our findings on smoking and tandoor fumes in EC patients were consistent with some previous studies. However, the findings of studies on the relationship between hot tea, reflux, and Van herbed cheese and EC risk are contradictory (2,3,(44)(45)(46)(47). These findings suggest that smoking and tandoor fumes may be risk factors for EC, but more research on hot tea/foods, reflux, and Van herbed cheese is needed.…”

“…There are two subtypes of EC, with esophageal squamous cell carcinoma (ESCC) being the most common in developing countries and esophageal adenocarcinoma (EAC) being the most common in industrialized countries (1). In Turkey, EC is more common, particularly in the eastern Anatolia region, with ESCC being the most common subtype (2)(3)(4)(5)(6)(7)(8). The environmental risk factors unique to each population are the most important reason for such disparities in results.…”

IGFBP5 is Upregulated and Associated with Poor Prognosis in Colorectal Cancer

“…The following steps were followed: (1) cancer cohort select: colorectal cancer (COADREAD), (2) search dataset selection: RNAseq, (3) search attribute select: IGFBP. (4) target dataset selection: RNAseq, (5) statistical method select: Spearman correlation analysis, (6) submitting the results of the previous step, selected GO and KEGG in GSEA for enrichment analysis. A false discovery rate (FDR) of <0.05 was used as the cutoff value for GO term and KEGG enrichment analysis.…”

“…The Methylation-related analysis was performed in LinkedOmics using the following 2) search dataset selection: RNAseq, (3) search attribute select: IGFBP, (4) target dataset selection: methylation 450, (5) statistical method select: Spearman correlation analysis. (6) submitting the results of the previous step. Spearman correlation analysis was performed to reveal the association between methylation level and gene expression, and a false discovery rate (FDR) of <0.05 was used as the cutoff value.…”

“…In addition, they interact with other proteins, such as cell surface proteins, extracellular matrix proteins, and intracellular molecules. 4 IGFBPs have been regarded as oncogene in a variety of tumors, such as IGFBP7 in breast cancer, 5 esophageal cancer 6 and hepatocellular cancer, 7 IGFBP1/2/4/5/6 in ovarian cancer. 8 IGFBP5 is a member of this family and plays an important role in cell growth, cell differentiation, apoptosis, and cell metabolism.…”