Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Gjuzelova, Aleksandra Aleksoska; Nakova, Valentina Velkoska; Nanovic, Zorica; Metodieva, Marija; Stojkoska, Aleksandra Jorganovic; Camurovski, Nikola; Mitreski, Vladimir; Krstevska, Slagjana Simeonova

doi:10.2478/prilozi-2023-0010

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Ferritin is another biomarker that has been associated with severity in adults and is able to predict poor outcomes and prognosis, although its use is still somewhat contested [ 47 , 48 , 49 ]. In our patients, ferritin proved to be a good predictor of severity, ICU admission and death.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Biomarkers Comparison: Children, Adults and Elders

et al. 2023

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Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol and clinical severity in patients from the western part of Romania, and compare their potential use as biomarkers for intensive care units (ICU) admission and death in children, adults and elders. Materials and Methods: this study is a retrospective cohort study, performed on patients positively diagnosed with COVID-19. Available CRP, LDH, CK 25-OH vitamin D, ferritin, HDL cholesterol and clinical severity were recorded. The following were assessed: median group differences, association, correlation and receiver operating characteristic. Results: 381 children, 614 adults and 381 elders were studied between 1 March 2021 and 1 March 2022. Most children and adults presented mild symptomatology (53.28%, 35.02%, respectively), while most elders presented severe symptomatology (30.04%). ICU admission was 3.67% for children, 13.19% for adults and 46.09% for elders, while mortality was 0.79% for children, 8.63% for adults and 25.1% for elders. With the exception of CK, all other biomarkers showed some significant associations with clinical severity, ICU admission and death. Conclusions: CRP, LDH, 25-OH vitamin D, ferritin and HDL are important biomarkers for COVID-19 positive patients, especially in the pediatric population, while CK was mostly within normal ranges.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Biomarkers Comparison: Children, Adults and Elders

et al. 2023

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“…One of the key features of COVID-19 is the exacerbated inflammatory status seen in some patients, especially those who develop severe disease [ 19 , 20 ]. Specialized studies have demonstrated that several types of immune cells and inflammatory mediators are involved in the process and progression of the disease [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Inflammatory Profile Correlates with COVID-19 Severity and Mortality in Cancer Patients

Budin,

Nemeș,

Râjnoveanu

et al. 2023

JPM

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Background: The correlation of the inflammatory profile with the severity of the disease in neoplastic patients with SARS-CoV-2 infection was addressed. Methods: A database of 1537 patients hospitalized in the pneumology department was analyzed. After applying the inclusion and exclusion criteria, 83 patients (67% males, 33% females) were included. Results: Most of the analyzed patients were hospitalized with a moderate form of disease, explaining the significant percentage of 25% mortality. The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. We identified a significant association between the increased value of ferritin (p < 0.0001, OR = 22.31), fibrinogen (p = 0.009, OR = 13.41), and C-reactive protein (p = 0.01, OR = 7.65), respectively, and the level of severity of COVID-19. The results of the univariate logistic regression analysis for predicting the severity of the disease revealed that the increased values of ferritin (p = 0.001, OR = 22.31) and fibrinogen (p = 0.02, OR = 13.41) represent a risk for a serious negative prognosis of COVID-19. Conclusions: Our study demonstrated that the value of the analyzed inflammatory parameters increased in direct proportion to the severity of the disease and that higher values were associated with increased mortality in the study group.

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Role of Inflammatory Markers in Severity, ICU Admission, and Mortality in COVID-19: A Systematic Review and Meta-analysis of 79,934 Patients

Hiwa O. Abdullah,

Sadraldin A. Braim,

Maria A. Rasool

et al. 2024

Barw Medical Journal

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Introduction Despite extensive investigations into the roles of inflammatory biomarkers in the prognosis of COVID-19 through systematic reviews and meta-analyses, they are limited by small sample sizes and focus on a specific marker. This meta-analysis investigated the role of 11 inflammatory biomarkers in severity, intensive care unit (ICU) admission, and mortality among COVID-19 patients. Methods Studies up to October 25, 2023, were identified through a search of Google Scholar, limited to human studies published in English. Inclusion criteria required confirmed COVID-19 cases diagnosed via reliable laboratory methods, original articles from eligible journals, proper grouping of severity status, ICU admission, or mortality outcomes, and presentation of continuous data in mean and standard deviation, median with range, or interquartile range. Results A total of 241 studies, comprising 79,934 cases of COVID-19, were included in this study. Albumin levels significantly declined in severe, ICU, and dead cases compared to mild, moderate, non-ICU, and survived cases (p<0.001). C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), ferritin, fibrinogen, Interleukin-6 (IL-6), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), procalcitonin, and white blood cell (WBC) were all significantly (p<0.001) increased and correlated with the severity of COVID-19. CRP, D-dimer, ferritin, fibrinogen, IL-6, LDH, NLR, procalcitonin, and WBC were all significantly (p<0.05) elevated and correlated with the risk of ICU admission (except fibrinogen) and mortality in COVID-19 in both fixed and random effects. Conclusion Inflammatory biomarkers like albumin, CRP, D-dimer, ferritin, IL-6, LDH, NLR, procalcitonin, and WBC all significantly impact severity status, ICU admission, and mortality in COVID-19.

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Association of Inflammatory Markers with Disease Severity and Outcome in Covid-19 Patients

Cited by 3 publications

References 27 publications

COVID-19 Biomarkers Comparison: Children, Adults and Elders

COVID-19 Biomarkers Comparison: Children, Adults and Elders

The Inflammatory Profile Correlates with COVID-19 Severity and Mortality in Cancer Patients

Role of Inflammatory Markers in Severity, ICU Admission, and Mortality in COVID-19: A Systematic Review and Meta-analysis of 79,934 Patients

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