Association of Inflammatory Marker and Highly Sensitive C-Reactive Protein With Aerobic Exercise Capacity, Maximum Oxygen Uptake and Insulin Resistance in Healthy Middle-Aged Volunteers

Abstract

performed. These examinations consisted of medical examinations, the administration of a questionnaire on physical activity, and an exercise test to evaluate aerobic exercise capacity. Based on the results of these evaluations, indusCirc J 2005; 69: 452 -457 (Received November 12, 2004; revised manuscript received January 17, 2005; accepted January 28, 2005 Background Increased levels of inflammation markers, such as C-reactive protein (CRP) and tumor necrosis factor-, have been found in insulin resistance syndrome. Those with elevated levels of high-sensitive CRP (hs-CRP) are at a higher risk for coronary heart disease. In the present study, we evaluated whether maximum oxygen uptake and insulin resistance are related to hs-CRP for the primary prevention of coronary heart disease. Methods and ResultsThe subjects were 50 subjects who did not have diabetes mellitus. A multi-step treadmill exercise test was performed to obtain the maximum oxygen uptake when assessed by computerized breathby-breath analysis. As an index of insulin resistance, the homeostasis model insulin resistance index (HOMA-R; fasting glucose × fasting insulin/405) was used. In addition, bodyweight, body mass index, subcutaneous fat thickness, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride were measured. Multivariate analysis revealed that hs-CRP was significantly correlated with HDL-cholesterol, uric acid, -glutamyl transpeptidase and maximum oxygen uptake. The maximum oxygen uptake showed the smallest odds ratio was in terms of the relationship with hs-CRP. Conclusions The present study suggests that the development of exercising habits increases the maximum oxygen uptake. Furthermore, an elevated maximum oxygen uptake decreases HOMA-R and reduces the inflammatory marker CRP, suggesting that exercising habit plays an important role in the primary prevention of coronary heart disease. (Circ J 2005; 69: 452 -457)

Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

“…SUA can also promote LDL cholesterol in vitro [26]. An association between SUA levels and inflammatory markers has also been discovered [27][28][29]. Uric acid has also been found in the atherosclerotic plaques.…”

Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome

“…[42][43][44][45] Hypoadiponectinemia is also located upstream of the pathogenesis of metabolic diseases and atherosclerosis. [23][24][25] However, the precise molecular mechanism of adipocytokine dysregulation has not been fully elucidated.…”

Differential Response to Exercise in African Americans with High Levels of Inflammation

“…35,36 Again, the lack of improvement in the HI group might support the hypothesis that even though CRP levels systemic inflammation. 26,27 This could explain the discrepancy of aerobic fitness between our groups prior to exercise, although we controlled for physical activity levels in our sample prior to the inclusion into our study. The lack of improvement of aerobic fitness in the HI group, which is not something to be expected in light of a six-month aerobic exercise intervention, could possibly be explained by other diminished cardiovascular components influenced by chronic and systemic inflammation, which were not assessed in our study.…”