Association of Inflammatory Eye Disease With Granuloma Annulare?

Brey, Nicole Vessels; Purkiss, Todd J.; Sehgal, Ashok; Kaplan, Henry J.; Callen, Jeffrey P.

doi:10.1001/archderm.144.6.803

Cited by 11 publications

(3 citation statements)

References 5 publications

(6 reference statements)

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“…with some frequency as being associated with GA are uveitis [17,18], sarcoidosis [19,20], necrobiosis lipoidica [21], and Sweet syndrome [22]. In the present study we did not detect a significant association with any of them.…”

Section: Discussioncontrasting

confidence: 78%

Granuloma annulare: a case-control study of possible associated diseases.

Fornons-Servent¹,

Bauer-Alonso²,

Llobera-Ris³

et al. 2022

Dermatol Pract Concept

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Introduction: Granuloma annulare (GA) has been reported as associated with multiple diseases, mainly diabetes mellitus (DM), thyroid diseases, and dyslipidemia. However, the high prevalence of some of these illnesses makes it difficult to assess whether the association is real or fortuitous. Our objective was to analyse the clinical features of our GA patients and the possible associations. Methods: This is a retrospective observational study of 225 patients with biopsy-proven GA diagnosed between 2009 and 2019 in a referral university hospital in Barcelona, Spain. Clinical charts were reviewed to obtain clinical data. As a control group we used a random list of 225 patients diagnosed in the hospital's traumatology department in the same period, matched by age and sex. Results: Diabetes was diagnosed in 40 GA patients (18%) (34 in the control group, 15%) and hypothyroidism in 33 (15%) (22 in the control group 9.8%); the differences were not significant. We also did not detect any association with uveitis, sarcoidosis, necrobiosis lipoidica, Sweet's syndrome, HIV infection, hepatitis B, or haematological malignancies. We only detected a possible association with hepatitis C (6 GA patients, 2.7%, versus 0 controls, p = 0.03), and hypercholesterolemia (108 GA patients, 48%, versus 79 controls, 35%, p = 0.007). Conclusions: The possible pathogenic explanations for the association with hepatitis C and hypercholesterolemia seem unlikely. We consider that the association of GA with other diseases, including hypercholesterolemia and hepatitis C, is doubtful and that it there is no justification rule out possible associated diseases in patients with GA.

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Section: Discussioncontrasting

confidence: 78%

Granuloma annulare: a case-control study of possible associated diseases.

Fornons-Servent¹,

Bauer-Alonso²,

Llobera-Ris³

et al. 2022

Dermatol Pract Concept

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“…Our case is further complicated by the occurrence of anterior left uveitis. The association between granuloma annulare and uveitis has been reported formerly [8][9][10][11][12], and may occur without underlying sarcoidosis. Our patient never displayed any symptoms for such condition.…”

Section: Discussionmentioning

confidence: 98%

Simultaneous occurrence of generalized granuloma annulare, anterior uveitis and giant cell arteritis: Coincidental or not?

et al. 2012

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“…8,9 Association with uveitis is not frequent enough to systematically screen patients with subcutaneous granuloma annulare for uveitis. 10 None of our patients reported itchy, painful, or red lesions at any point in time. When a healthy child presents with subcutaneous periocular lesions that are not tender, red, or itchy; are of several weeks or months duration; and are sometimes recurrent, a diagnosis of subcutaneous granuloma annulare should be suspected, even in the absence of an annular pattern.…”

Section: Discussionmentioning

confidence: 59%