Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: A systematic review and meta-analysis

Xiong, Qin; Fuyou, Tang; Yilin, Li; Xie, Fengjiao; Liu, Yuan; Yao, Chenjiao; Wu, Ruike; Juan, Wang; Wang, Qiuxiang; Peimin, Feng

doi:10.1016/j.jpsychores.2022.110983

Cited by 15 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In total, we included data from 33 meta-analyses reporting on 38 risk factors for suicide mortality ( appendix pp 15–16 ). 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 …”

Section: Resultsmentioning

confidence: 99%

Individual-level risk factors for suicide mortality in the general population: an umbrella review

Favril,

Yu,

Geddes

et al. 2023

The Lancet Public Health

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Individual-level risk factors for suicide mortality in the general population: an umbrella review

Favril,

Yu,

Geddes

et al. 2023

The Lancet Public Health

View full text Add to dashboard Cite

“…Indeed, the markers of bacterial translocation into the host circulatory system, including lipopolysaccharide (LPS) and intestinal fatty-acid binding protein (I-FABP), were reported to be elevated in individuals with recent suicide attempts, connecting this pathology with dysfunctional gut barrier [7]. This is further substantiated by the earlier studies which reported increased suicide rates in patients with inflammatory bowel disease (IBS), further connecting microbial translocation outside the gastrointestinal (GI) tract with this behavior [8,9]. Commensal microbes express proteins identical or similar to those of the human host, likely activating the immune system upon translocation, causing pathology.…”

Section: Introductionmentioning

confidence: 83%

The Immunology Of Suicidal Behavior

Sfera¹,

Andronescu²,

Anton³

et al. 2023

ACMR

View full text Add to dashboard Cite

“…Furthermore, somatic illnesses that could predispose an individual to SI/SB development include neurological diseases, inflammatory bowel disease, diabetes, stroke, chronic obstructive pulmonary disease, osteoporosis, and chronic pain. These conditions have been identified as independent predictors of SI/SB [10][11][12]. Elevated suicide risk has been also associated with infections by various pathogens, including Toxoplasma gondii and Cytomegalovirus [13,14].…”

Section: Suicide Risk In Patients With Psychiatric and Physical Illne...mentioning

confidence: 99%

A Prospective Multicenter Longitudinal Analysis of Suicidal Ideation among Long-COVID-19 Patients

Costanza,

Amerio,

Aguglia

et al. 2024

Healthcare

View full text Add to dashboard Cite

Long coronavirus disease 19 (COVID-19) is an emerging multifaceted illness with the pathological hallmarks of chronic inflammation and neuropsychiatric symptoms. These pathologies have also been implicated in developing suicidal behaviors and suicidal ideation (SI). However, research addressing suicide risk in long COVID-19 is limited. In this prospective study, we aim to characterize SI development among long-COVID-19 patients and to determine the predictive power of inflammatory markers and long-COVID-19 symptoms—including those of psychiatric origin—for SI. During this prospective, longitudinal, multicenter study, healthy subjects and long-COVID-19 patients will be recruited from the University Hospital of Geneva, Switzerland, the University of Genova, the University of Rome “La Sapienza”, and the University of San Francisco. Study participants will undergo a series of clinic visits over a follow-up period of 1 year for SI assessment. Baseline and SI-onset levels of inflammatory mediators in plasma samples, along with 12 long-COVID-19 features (post-exertional malaise, fatigue, brain fog, dizziness, gastrointestinal disturbance, palpitations, changes in sexual desire/capacity, loss/change of smell/taste, thirst, chronic cough, chest pain, and abnormal movements) will be collected for SI risk analysis. The proposed enrollment period is from 15 January 2024 to 15 January 2026 with targeted recruitment of 100 participants for each study group. The anticipated findings of this study are expected to provide important insights into suicide risk among long-COVID-19 patients and determine whether inflammation and psychiatric comorbidities are involved in the development of SI in these subjects. This could pave the way to more effective evidence-based suicide prevention approaches to address this emerging public health concern.

show abstract

Association of inflammatory bowel disease with suicidal ideation, suicide attempts, and suicide: A systematic review and meta-analysis

Cited by 15 publications

References 63 publications

Individual-level risk factors for suicide mortality in the general population: an umbrella review

Individual-level risk factors for suicide mortality in the general population: an umbrella review

The Immunology Of Suicidal Behavior

A Prospective Multicenter Longitudinal Analysis of Suicidal Ideation among Long-COVID-19 Patients

Contact Info

Product

Resources

About