Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

Chen, Chung-Yao; Chen, Chia‐Ling; Yu, Chung-Chieh; Chen, Tai-Tzung; Tseng, Shih-Ting; Ho, Cheng-Ting

doi:10.1016/j.sleep.2014.07.027

Cited by 30 publications

(20 citation statements)

References 42 publications

(48 reference statements)

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“…Interestingly, all of these biomarkers except fibrinogen were correlated with sleep time spent with SaO 2 less than 90% (TST90), and fibrinogen was related to active smoking [ 34 ]. Similar studies conducted by other researchers demonstrated parallel results; CRP was positively correlated with AHI, even adjusted for BMI [ 39 – 42 ].…”

Section: Inflammation In Osassupporting

confidence: 84%

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Liu

Ouyang

et al. 2020

J Neuroinflammation

112

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Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), leading to cognitive dysfunction, a significant and extraordinary complication of OSAS patients. The repeated courses of airway collapse and obstruction in OSAS patients resulted in apnea and arousal during sleep, leading to IH and excessive daytime sleepiness (EDS) and subsequently contributing to the development of inflammation. IH-mediated inflammation could further trigger various types of cognitive dysfunction. Many researchers have found that, besides continuous positive airway pressure (CPAP) treatment and surgery, anti-inflammatory substances might alleviate IH-induced neurocognitive dysfunction. Clarifying the role of inflammation in IH-mediated cognitive impairment is crucial for potentially valuable therapies and future research in the related domain. The objective of this article was to critically review the relationship between inflammation and cognitive deficits in OSAS.

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Section: Inflammation In Osassupporting

confidence: 84%

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Liu

Ouyang

et al. 2020

J Neuroinflammation

112

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“…It has also been reported that oxidative stress, subclinical systemic inflammation, and endothelial dysfunction may mediate the effects of short sleep duration and low sleep quality [35,36,37]. Short sleep duration and low sleep quality have been shown to induce a proinflammatory state, characterized by increased levels of several cytokines, including IL1β, TNFα, IL6, and IL17 [38,39,40].…”

Section: Potential Mechanisms Underlying Association Of Sleep Withmentioning

confidence: 99%

“…Other reports have shown that oxidative stress, such as total antioxidant capacity (TAC) and 8-hydroxy-2-deoxyguanosine (8-OHdG), is elevated in patients with OSA. Oxidative stress may be involved in dysregulation of collagen and elastin fibers of the vascular wall, leading to increased arterial stiffness [36,43]. Furthermore, study findings have indicated that OSA can lead to endothelial dysfunction and arterial disease [37], in which intermittent hypoxia and intrathoracic pressure changes may be involved.…”

Section: Potential Mechanisms Underlying Association Of Sleep Withmentioning

confidence: 99%

Sleep, Autonomic Nervous Function and Atherosclerosis

Kadoya

Koyama

2019

IJMS

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Behavioral and psychosocial factors related to development of cardiovascular disease have been gaining increased attention. Notably, sleep is considered to be one of the most important behavioral factors involved in progression of atherosclerosis and cardiovascular events, with autonomic nervous function a potential mechanism. Several studies have shown associations of sleep and autonomic dysfunction with major surrogate markers of atherosclerosis, such as carotid intima-media thickness and arterial stiffness. Endocrinological, immunological, oxidative, inflammatory, and metabolic responses, as well as endothelial dysfunction may mediate the effects of the autonomic nervous system. For this review, we examined recent findings related to sleep, autonomic nervous dysfunction, and atherosclerosis, with the aim of understanding the involved pathophysiological mechanisms.

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“…A large lipid core is an important contributor to plaque rupture through mechanically increasing the tension of the fibrous cap covering the lipid core, leading to disruption [35]. In patients with OSA, intermittent hypoxia (IH) during sleep can increase oxidative stress, leading to oxidative modification of lipoproteins and other molecules [36–38]. These oxidized particles cause endothelial surface injury and promote accumulation of cholesterol in atherosclerotic plaque [39, 40].…”

Section: Lipid-rich Plaquementioning

confidence: 99%

Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

et al. 2019

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Obstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non–OSA patients treated between October 2015 and October 2018. Plaque morphology was evaluated for 70 lesions, including 21 from patients with OSA and 49 from non–OSA patients. Compared with the non–OSA group, patients with OSA had significantly higher prevalences of thinned cap fibroatheroma (TCFA) (67% vs. 35%, P = 0.014) and microchannels (86% vs. 55%, P = 0.014); a significantly higher mean lipid index (1392 ± 982 vs. 817 ± 699, P = 0.021), macrophage grade (8.4 ± 6.4 vs. 4.8 ± 4.5, P = 0.030), and maximum number of microchannels (1.5 ± 1.0 vs. 0.7 ± 0.7, P = 0.001); and a significantly lower mean minimum fibrous cap thickness (69.4 ± 28.7 vs. 96.1 ± 51.8 μm, P = 0.008). This OFDI analysis suggests that OSA is associated with unstable plaque characteristics in patients with CAD. More intensive medical management for stabilization of coronary atherosclerotic plaque is required in patients with OSA. Electronic supplementary material The online version of this article (10.1007/s00380-019-01363-8) contains supplementary material, which is available to authorized users.

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Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

Cited by 30 publications

References 42 publications

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Sleep, Autonomic Nervous Function and Atherosclerosis

Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study

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