Association of Inflammation and Cytotoxin‐Associated Gene A Positive Strains of <i>Helicobacter Pylori</i> in Cardiac Syndrome X

Rasmi, Yousef; Raeisi, Sina; Mohammadzad, Mir Hosein Seyyed

doi:10.1111/j.1523-5378.2011.00923.x

Cited by 28 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CagA-positive H. pylori infection plays a critical role in various diseases via changes in inflammation and immune response. The data from one study[19] demonstrated that a CagA+ strain of H. pylori not only can be a trigger but also may result in chronic inflammation involved in the pathogenesis of cardiac syndrome X (CSX). In addition, the cag pathogenicity island (cagPAI) is critical for H. pylori pathogenesis in bile duct cells[20].…”

Section: Discussionmentioning

confidence: 99%

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Wang

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

Different amounts of ingested alcohol can have distinct effects on the human body. However, there is limited research on chronic alcohol consumption with Helicobacter pylori infection. We sought to investigate the relationship between the cytokine profile, oxidative balance and H. pylori infection in subjects with chronic alcohol consumption. A total of 142 subjects were divided into three groups: 59 subjects with chronic alcohol ingestion and H. pylori infection (group A); 53 subjects with chronic alcohol ingestion without H. pylori infection (group B); and 30 control subjects (group C). The serum levels of CagA, interleukin (IL)-10, E-selectin, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD) activity were measured by enzyme-linked immunosorbent assay (ELISA). We found that the ages and serum H. pylori CagA levels among the three groups, as well as both the mean drinking age and the mean daily alcohol consumption between groups A and B, were matched and comparable. Comparing the BMIs among the three groups, the BMI differences were found to be statistically significant (F=3.921, P<0.05). Compared with group C, the BMIs in groups A and B were significantly higher (P<0.001 and P<0.01, respectively); however, the BMI differences between group A and group B were not statistically significant (P>0.05). Additionally, no differences in the serum CagA levels were found in comparisons among the groups (all P>0.05). The serum IL-10 and E-selectin levels in group A were significantly lower than those in group B (serum IL-10: P<0.05; E-selectin: P<0.05). The serum IL-10 in group A was significantly higher than that in group C (P<0.01); the serum E-selectin levels in group A did not significantly differ compared with those in group C (P>0.05). Furthermore, the serum IL-10 and E-selectin levels in group B were significantly higher than those in group C (serum IL-10: P<0.001; E-selectin: P<0.05); however, the serum TNF-α levels did not differ among groups (all P>0.05). Although the serum levels of MDA and SOD in groups A and B were slightly lower than those in group C, there were no significant differences among groups (all P>0.05). In conclusion, we believe that H. pylori infection might cause a significant inhibition of certain cytokine profiles in subjects with chronic alcohol ingestion. Moreover, chronically ingested alcohol may exert an adjusted inflammatory effect, but there was no association between H. pylori infection, chronic alcohol consumption and oxidative balance.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Wang

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Although we have evaluated systemic inflammation through this analyte, we agree that other parameters should be useful and more specific to determine a possible link between H. pylori's infection and systemic inflammation. In example, some studies have considered to study as inflammation markers interleukin-6 (IL-6), IL-8 and TNF-α, which seems to be specially related to bacterial infection (3,34) . As mentioned above, regarding the remarkable association between the presence of anti-CagA antibodies and higher tissue damage, although with no systemic responses through the measurement of hsCRP levels, we encourage the development of further studies involving additional inflammatory markers that could be related to higher systemic inflammation in functional dyspeptic people carrying H. pylori and its virulence factor.…”

Section: Discussionmentioning

confidence: 99%

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Andreolla

Bona

Sander

et al. 2016

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -Recently, a great variety of studies aimed to investigate and even suggest Helicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective -The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods -Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status of H. pylori positive individuals was determined through an imunoenzimatic assay. Results -Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis (yerba maté) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion -No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba maté should be considered as a cultural factor possibly related to H. pylori's transmission. According to the recent reports, CagA positive strains can cause severe damage to the gastric epithelium, being related specially with increased levels of interleukin-8 (IL-8), gastroduodenal ulcers and gastric neoplasia occurrence (26,29,41) . In addition, this virulence factor has been associated with systemic inflammation, resulting in high serum C-reactive protein (CRP) levels and the bacteria presence being related to higher cardiovascular risks (21,37) . Some behaviors have been associated to the transmission of H. pylori. Studies have reported that several aspects can be related to incidence and prevalence rates like socioeconomic status, years of study, institutionalization practice or social habits (8,20) . In 2010, a Brazilian study has demonstrated an anti-H. pylori activity of plant extracts, like yerba maté tea (Ilex paraguariensis), but no association between bacteria prevalence and tea consumption has been previously described (6) . Andreolla HF, Bona LR, Sander GB, Mazzoleni LE, Tavares RG, Prolla JC. Lack of association between Helicobacter pylori's virulence and increased serum C-reactive protein levels in functional dyspeptic patients HEADINGS - 50Arq Gastroenterol v. 53 no. 1 -jan./mar. 2016All H. pylori's infected people present histological gastritis. Moreover, the bacteria, classified as type I carcinogen (32) , has been associated with the...

show abstract

“…Since then, many studies have been demonstrated an association between H.pylori infections and some vascular diseases, such as ischemic heart disease [16]. Chronic infection may be accompanied by persistently increased production of inflammatory metabolites [8]. H.pylori produces some antigenic substances, including heat shock protein, urease, and lipopolysaccharide, all of which can be taken up and processed by lamina properia macrophages and active T-cells and cause increased production of inflammatory cytokines such as interleukine-1 (IL-1), IL-6, tumor necrosis factor alpha (TNFa), and most important IL-8.…”

Section: Discussionmentioning

confidence: 99%

“…Hcy is a sulphur amino acid formed from methionine during transmethylation, and is either salvaged to methionine by a folate and co-balamin-dependent re-methylation reaction or directed toward degradation by vitamin B 6 -dependent enzyme cystathionine beta-synthase [6,7]. Also, previous studies has shown an association between viral and bacterial infections including Helicobacter pylori (H.pylori) and some vascular disease such as CSX [8]. H.pylori is a spiral shaped positive gram that cause the most common chronic bacterial infection in the world [9].…”

Section: Introductionmentioning

confidence: 99%

Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Rasmi

Mehraban²,

Sadreddini³

et al. 2012

Cardiol J

Self Cite

View full text Add to dashboard Cite

Association of Inflammation and Cytotoxin‐Associated Gene A Positive Strains of Helicobacter Pylori in Cardiac Syndrome X

Abstract: The CagA+ strain of H. pylori, can not only be a trigger, and may also have a role via chronic inflammation in the pathogenesis of CSX.

Cited by 28 publications

References 29 publications

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Effect of H. pylori Infection on Cytokine Profiles and Oxidative Balance in Subjects with Chronic Alcohol Ingestion

Lack of Association Between Helicobacter Pylori's Virulence and Increased Serum C-Reactive Protein Levels in Functional Dyspeptic Patients

Lack of significant association between Helicobacter pylori infection and homocysteine levels in patients with cardiac syndrome X

Contact Info

Product

Resources

About