Association of in vitro fertilization outcome with circulating insulin-like growth factor components prior to cycle initiation

Ramer, Ilana; Kanninen, Tomi T.; Sisti, Giovanni; Spandorfer, Steven D.

doi:10.1016/j.ajog.2015.04.026

Cited by 12 publications

(10 citation statements)

References 27 publications

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“…Various studies have reported that neonatal respiratory disease and related treatments are closely related to the occurrence of ROP. 21,[28][29][30] In this study, the risk of ROP development was five times higher in infants with BPD, similar to the findings by Gebes çe et al (OR ¼ 5.952; 95% CI 2.030-17.447). 22 Also, BPD was found to be the most powerful risk factor for the development of ROP and a strong predictor of the severity of ROP in our study.…”

Section: Neonatal Factors and Ropsupporting

confidence: 91%

“…20 A few studies have reported that IVF pregnancy with higher serum level of IGF may predict better oocyte quality or the success of embryo implantation. 21 Thus, the level of IGF in IVF pregnant mothers may have an impact on ROP, which has not been previously evaluated. In this study, IVF mainly increased the risk of stage 1 ROP, inconsistent with the results of previous studies.…”

Section: Maternal Obstetric Factors and Ropmentioning

confidence: 98%

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Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Zhang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Section: Neonatal Factors and Ropsupporting

confidence: 91%

Section: Maternal Obstetric Factors and Ropmentioning

confidence: 98%

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Zhang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…The study of IVF-ET procedures provides an important opportunity to explore embryo implantation processes that cannot be observed in spontaneous conception. Large, population-based studies have shown that tubal infertility, the number of embryos transferred, length of embryo culture and some metabolic pathways and proteins are significantly associated with the incidence of EP [12–14]. With a reduction in tubal factor infertility, transferring fewer embryos, and extended embryo culture, EP rates following IVF-ET have progressively decreased [15].…”

Section: Discussionmentioning

confidence: 99%

“…Recent efforts have been made to predict the occurrence of EP prior to an IVF cycle, without defining a clear algorithm yet [12–14]. In the present study, we wondered if DOR can predict the occurrence of EP.…”

Section: Introductionmentioning

confidence: 91%

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

et al. 2017

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The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5–5-fold compared with natural conceptions.Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L). During cycles following fresh embryo transfer, 93 patients were diagnosed with ectopic pregnancy. The incidence of ectopic pregnancy in clinical pregnancies was significantly higher in the decreased ovarian reserve than in the normal ovarian reserve group (5.51% vs. 2.99%). After adjusting for confounding factors, the incidence of ectopic pregnancy was significantly associated with decreased ovarian reserve. Our results showed that decreased ovarian reserve is an independent risk factor for ectopic pregnancy after in vitro fertilization-embryo transfer.

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“…While it would have been advantageous to include these measurements, their analysis would not necessarily directly relate to the state of immunity at the maternal-fetal interface which differs from that present in the peripheral circulation [6]. In addition, other possible influences on immune regulation such as circulating levels of insulin [20] or IGF-2 [21] were not evaluated in our study. Although we did utilize a control group that underwent IVF using homologous oocytes, it cannot be definitively ruled out that conditions unique to the collection, incubation and transfer of donor oocytes had an unknown effect on IGFBP-1 production.…”

Section: Discussionmentioning

confidence: 99%

Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes

et al. 2019

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Background and Objectives: To investigate if pregnancies conceived using an oocyte donor necessitate an alteration in immune regulation, we compared concentrations of insulin-like growth factor binding protein (IGFBP)-1, insulin-like growth factor (IGF)-1 and T cell immunoglobulin mucin-3 (Tim-3) in women with ongoing successful twin pregnancies conceived spontaneously, using assisted reproductive technologies that utilized homologous oocytes or with donor oocytes. Differences in levels of these immune modulatory proteins may be magnified and easier to detect in twin as compared to singleton pregnancies. Methods: In this prospective study IGFBP-1 and IGF-1 were measured in sera and Tim-3 in lysates of peripheral blood mononuclear cells (PBMCs) by ELISA. Results: Median IGFBP-1 levels were lower in women with donor oocytes (41.4 ng/ml) as compared to those with a spontaneous conception (51.2 ng/mL) or who conceived with various assisted reproduction protocols using homologous oocytes (52.4 ng/mL) (p < 0.001). IGF-1 and Tim-3 levels were comparable in each group. The IGFBP-1 level was inversely correlated to the IGF-1 concentration only in women with donor oocytes (p = 0.032). IGFBP-1 and Tim-3 levels were similarly negatively correlated in the donor oocyte group (p = 0. 012). Women in the assisted reproduction group who conceived following intracytoplasmic sperm injection were the only other group in which IGFBP-1 and Tim-3 were negatively correlated (p = 0.018). Conclusions: Down-regulation of IGFBP-1 production in pregnancies conceived with donor oocytes may reduce the extent of pro-inflammatory immunity and contribute to successful outcome in totally allogeneic pregnancies.

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Association of in vitro fertilization outcome with circulating insulin-like growth factor components prior to cycle initiation

Cited by 12 publications

References 27 publications

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes

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