Association of Imaging Classification of Intracranial Cerebral Atherosclerotic Vascular Stenosis in Ischemic Stroke and Renalase Gene Polymorphisms

Abstract

Cerebral atherosclerosis vascular stenosis is a common etiology for ischemic stroke and a major factor in recurrent stroke and vascular mortality. Recent studies suggest that renalase plays a role in hypertension and ischemic stroke, and may be involved in atherosclerosis. The aim of the present study was to investigate whether there were correlations between single-nucleotide polymorphisms (SNPs) in the renalase gene and severity of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke patients as determined by imaging. A total of 212 ischemic stroke patients and 244 healthy controls from the north Chinese Han population were enrolled in this study. Polymerase chain reaction and ligase detection reaction were used for SNP analysis. We classified the case samples by severity of the intracranial cerebral atherosclerotic vascular stenosis. Allele, genotype, and haplotype were analyzed in cases and controls, and logistic regression was used to adjust for bias due to conventional stroke risk factors. The allele and the genotype of rs10887800 in the renalase gene were both associated with severe intracranial cerebral atherosclerotic vascular stenosis (p = 0.013 and p = 0.049, respectively). No association was observed with severity for SNP rs2576178 or SNP rs2296545. Our findings show that the SNP rs10887800 in the renalase gene is closely associated with severe intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke patients of north Chinese Han origin.

Renalase

“…Correlation between renalase SNPs and severity of intracranial cerebral atherosclerotic vascular stenosis was examined in 212 ischemic stroke patients and 244 healthy controls from the northern Chinese Han population [25]. SNP rs10887800 in the renalase gene was associated with severe intracranial cerebral atherosclerotic vascular stenosis.…”

Association studies of candidate single-nucleotide polymorphisms with Symptomatic Intracranial Atherosclerotic Stenosis in a Chinese Han population

“…Intracranial atherosclerosis can be considered as a multifactorial process in which atherosclerotic risk factors like hypertension, dyslipidemia, diabetes, were involved in the disease development process [29][30][31][32]. Hereditary factors are also believed to play important roles in sICAS as associations of intracranial atherosclerosis and genetic polymorphisms are described in several studies [8][9][10][11][12][13][14][15]. Thus, 96 SNPs were examined in the present study, which were all proved to be related to ischemic stroke, atherosclerosis and coronary atherosclerotic heart diseases.…”

“…Yet, unlike other vascular diseases, little is known regarding associations of sICAS and genetic polymorphisms. Recent genetic studies have suggested the importance of genetic factors in predisposition to sICAS such as genotypes or polymorphisms of APOE, CRP, Renalase, RNF213, LPL and ALDH2 [8][9][10][11][12][13][14][15][16], but few candidate genes have been replicated. Genetic research of subjects who had sICAS can be a promising approach for identification of novel biological mechanisms that underlie the development of sICAS.…”

Pooled genetic analysis reveals an association of snps of only a few genes with risk predisposition to ischemic stroke in a Chinese population

“…Our results demonstrate the top level genes that are related to normal vascular physiology, viz. genes of nitric oxide synthesis, endothelial health and smooth muscle biology .…”

“…We found renalase has comparative high relationship with IS; this gene encodes a novel flavin adenine dinucleotide‐dependent amine oxidase . This enzyme is secreted by the kidney and functions to catabolize circulating catecholamines, thus having a direct effect on cardiac function and systemic blood pressure (BP).…”