Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI

Shetelig, Christian; Limalanathan, Shanmuganathan; Hoffmann, Pavel; Seljeflot, Ingebjørg; Gran, Jon Michael; Eritsland, Jan; Andersen, Geir Øystein

doi:10.1016/j.jacc.2018.04.053

Cited by 48 publications

(38 citation statements)

References 24 publications

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“…These results are consistent with what we previously reported, serum IL-8 expression was increased in acute myocardial infarctions (AMI) patients, and a higher serum IL-11 level was found in unstable angina pectoris group [30]. Other research groups have demonstrated that high levels of circulating IL-8 were associated with large infarct size, impaired recovery of left ventricular function, and adverse clinical outcome in patients with CAD [31][32][33][34][35]; Yao et al showed IL-11 was increased in thoracic aorta and plasma of acute thoracic aortic dissection (TAD) patients and may be a promising biomarker for diagnosis in patients with TAD [36].…”

Section: Discussionsupporting

confidence: 92%

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Gu¹,

Zhou²,

Wei³

et al. 2020

Preprint

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Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.

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Section: Discussionsupporting

confidence: 92%

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Gu¹,

Zhou²,

Wei³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…These results are consistent with what we previously reported, serum IL-8 expression was increased in acute myocardial infarctions (AMI) patients, and a higher serum IL-11 level was found in unstable angina pectoris group[30]. Other research groups have demonstrated that high levels of circulating IL-8 were associated with large infarct size, impaired recovery of left ventricular function, and adverse clinical outcome in patients with CAD[31][32][33][34][35]; Yao et al showed IL-11 was increased in thoracic aorta and plasma of acute thoracic aortic dissection (TAD) patients and may be a promising biomarker for diagnosis in patients with TAD[36]. 1R1 with IL-1ra (anakinra) is sufficient to attenuate the severity of acute heart failure [39].…”

supporting

confidence: 92%

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Zhou

Wei

et al. 2019

Preprint

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Background: While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods: The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results: The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity. Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype (P <0.05). Conclusions: These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.

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“…In addition, it reported that inflammation plays a critical role of total cardiovascular disease, ischemic heart disease, and myocardial infarction [ 41 , 42 ]. Higher levels of circulating interleukin (IL)-8 were associated with larger infarct size and more adverse clinical outcomes in patients with ST-segment elevation myocardial infarction [ 43 ]. Vieira et al [ 44 ] showed targetting of the lymphatic/immune cell axis as a therapeutic paradigm to promote immune modulation and heart repair.…”

Section: Discussionmentioning

confidence: 99%

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Cheng

Qiao

et al. 2018

Bioscience Reports

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There is increasing evidence that serum adipokine levels are associated with higher risks of cardiovascular diseases. As an important adipokine, fibroblast growth factor 21 (FGF21) has been demonstrated to be associated with atherosclerosis and coronary artery disease (CAD). However, circulating level of FGF21 in patients with angina pectoris has not yet been investigated. Circulating FGF21 level was examined in 197 patients with stable angina pectoris (SAP, n=66), unstable angina pectoris (UAP, n=76), and control subjects (n=55) along with clinical variables of cardiovascular risk factors. Serum FGF21 concentrations on admission were significantly increased more in patients with UAP than those with SAP (Ln-FGF21: 5.26 ± 0.87 compared with 4.85 ± 0.77, P<0.05) and control subjects (natural logarithm (Ln)-FGF21: 5.26 ± 0.87 compared with 4.54 ± 0.72, P<0.01). The correlation analysis revealed that serum FGF21 concentration was positively correlated with the levels of cardiac troponin I (cTnI) (r2 = 0.026, P=0.027) and creatine kinase-MB (CK-MB) (r2 = 0.023, P= 0.04). Furthermore, FGF21 level was identified as an independent factor associated with the risks of UAP (odds ratio (OR): 2.781; 95% CI: 1.476–5.239; P=0.002), after adjusting for gender, age, and body mass index (BMI). However, there were no correlations between serum FGF21 levels and the presence of SAP (OR: 1.248; 95% CI: 0.703–2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of UAP, that is independent of traditional risk factors of angina pectoris.

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Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI

Abstract: High levels of circulating IL-8 were associated with large infarct size, impaired recovery of LV function, and adverse clinical outcome in patients with STEMI, suggesting IL-8 as a future therapeutic target based on its important role in post-infarction inflammation.

Cited by 48 publications

References 24 publications

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

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