Association of IL-6 -176G &gt; C Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis

Veisian, Mehrnaz; Javaheri, Atiyeh; Amjadi, Nooshin; Tabatabaei, Razieh Sadat; Zanbagh, Leila; Hadadan, Amaneh; Abbasi, Hajar; Salimi, Erfaneh; Dastgheib, Seyed Alireza; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1675110

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…[19,32,33] Considering the importance of inflammation and genetic polymorphisms in the etiology and progression of PE, a growing number of studies have been performed to explore the associations between inflammatory gene polymorphisms and susceptibility to PE. [21][22][23][34][35][36][37][38][39][40][41][42] More and more meta-analysis have been conducted on the relationship between inflammatory factors IL-6, [43] TNF -a [44] and anti-inflammatory factors IL-10 [45] gene polymorphism and PE, which further indicates that gene polymorphism is closely related to the susceptibility of PE. In the present study, we synthesized data from published studies to explore the relationship between the risk of PE and other commonly studied polymorphisms of the IL-10 -819C/T and -592A/C.…”

Section: Discussionmentioning

confidence: 99%

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Che

Liu

et al. 2021

Medicine

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Objective: The purpose of our study was to investigate whether IL-10 -819C/T, -592A/C polymorphisms were associated with preeclampsia (PE) susceptibility.Methods: A comprehensive and systematic literature search was performed through online databases, including Web of Science, PubMed, EMBASE, and Chinese databases. Then eligible literatures were included according to inclusion criteria and exclusion criteria. Statistical data analysis was performed using Stata 10.0 software. Odds ratios (OR) and 95% confidence interval were applied to evaluated the association between IL-10 -819C/T, -592A/C polymorphisms and PE susceptibility.Results: According to inclusion and exclusion criteria, 9 case-control studies, including 1423 cases and 2031 controls, were included in this meta-analysis. Our meta-analysis revealed that no association was found between IL-10 -819C/T, -592A/C polymorphisms and the risk of PE in our study. Conclusion:Our meta-analysis suggested that IL-10 -819C/T and -592A/C polymorphisms had no association with PE susceptibility, but had a significant association with PE susceptibility in Asian and Caucasian.

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Section: Discussionmentioning

confidence: 99%

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Che

Liu

et al. 2021

Medicine

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“…The human IL6 gene is located on the short arm of chromosome 7 (7p21). 60 However, no significant association of the IL6 -176G > C, -572G > C, and -597G > A polymorphisms with PE risk was found in Finland, Austria, Brazil, Mexico, Saudi, Turkey, Scotland, India, and China populations. 46,60 2.3.6 | ERAP1 and ERAP2 genes Endoplasmic reticulum aminopeptidases 1/2 (ERAP1/2) are zinc metallopeptidases that show regulatory roles in blood pressure via the RAS pathway.…”

Section: Acvr2a Genementioning

confidence: 97%

“…The human IL6 gene is located on the short arm of chromosome 7 (7p21) 60 . However, no significant association of the IL6 ‐176G > C, ‐572G > C, and ‐597G > A polymorphisms with PE risk was found in Finland, Austria, Brazil, Mexico, Saudi, Turkey, Scotland, India, and China populations 46,60 …”

Section: Genetic Polymorphisms Of Pihmentioning

confidence: 99%

“…Kong et al 42 found a positive linear correlation between the expression level of IL‐6 and systolic blood pressure in PIH women and a significant positive correlation between IL‐6 and blood pressure and adverse pregnancy outcomes in PIH women. The human IL6 gene is located on the short arm of chromosome 7 (7p21) 60 . However, no significant association of the IL6 ‐176G > C, ‐572G > C, and ‐597G > A polymorphisms with PE risk was found in Finland, Austria, Brazil, Mexico, Saudi, Turkey, Scotland, India, and China populations 46,60 …”

Section: Genetic Polymorphisms Of Pihmentioning

confidence: 99%

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The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

et al. 2022

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Pregnancy‐induced hypertension (PIH) is a multifactorial and severe pregnancy complication including preeclampsia/eclampsia, gestational hypertension, chronic (pre‐existing) hypertension, and preeclampsia/eclampsia variants superimposed on chronic hypertension. PIH‐induced maternal mortality accounts for approximately 9% of all maternal deaths over the world. A large number of case‐control studies have established the importance of various genetic factors in the occurrence and development of PIH. In this narrative review, we summarized the genetic risk factors involved in the renin‐angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks, with the aim of sorting out the genetic factors that may play a potential role in PIH and providing new ideas to elucidate the pathogenesis of PIH.

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“…They play important roles in the genetic anatomy of complex traits and diseases, and are useful for identifying population-based susceptibility genes ( 9 ). Genome-wide association and case–control studies have identified a series of susceptibility genes and susceptibility loci related to the risk of PE, including the zinc finger protein 831(ZNF831) gene polymorphism rs259983, FTO alpha-ketoglutarate dependent dioxygenase (FTO) rs1421085, MDS1 and EVI1 complex locus (MECOM) rs1918975, angiotensinogen (AGT) M235T, storkhead box 1 (STOX1) Y153H, and interleukin 6 (IL-6) 176 G>C ( 10 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of pre-eclampsia

et al. 2022

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ObjectiveThe aim of this study was to investigate the relationship between potential functional single-nucleotide polymorphisms (SNPs) of the angiotensin-converting enzyme 2 (ACE2) gene and the pathogenesis of pre-eclampsia (PE) in Guangxi, China.Materials and methodsA case–control study was conducted involving 327 PE cases and 591 age-matched, normal, singleton pregnant women. Potential functional ACE2 gene variants (rs2106809 A>G, rs6632677 G>C, and rs2074192 C>T) were selected and genotyped using kompetitive allele-specific PCR. The strength of the associations between the studied genetic variants and the risk of PE were evaluated using odds ratios (ORs) and corresponding 95% confidence intervals (CIs).ResultAfter adjusting for age and body mass index (BMI), unconditional logistic regression analysis showed that rs2106809 A>G was significantly associated with PE risk (AG vs. AA, OR = 1.43, 95% CI = 1.03–1.99, p = 0.034; AG/GG vs. AA, OR = 1.45, 95% CI = 1.06–1.99, p = 0.019), especially with severe PE (AG vs. AA, adjusted OR = 1.70, 95% CI = 1.10–2.61; AG/GG vs. AA, adjusted OR = 1.71, 95% CI = 1.14–2.57). Further stratified analysis showed that rs2106809 was even more pronounced in subjects in the pre-pregnancy BMI (pre-BMI) >23 kg/m2 (adjusted OR = 2.14, 95% CI = 1.32–3.45) and triglyceride (TG) >2.84 mmol/L subgroups (adjusted OR = 1.81, 95% CI = 1.09–3.01) under the dominant genetic model. We also found that rs2106809 interacted with pre-BMI (pinteraction = 0.040), thereby affecting an individual’s genetic susceptibility to PE. Multiple dimension reduction analysis demonstrated that rs2106809 made the best one-locus model, and the three-locus model was the best interaction model for predicting PE risk. Functional analysis suggested that rs2106809 A>G causes a change in the reliability of classifications of two putative splice sites in the ACE2 gene, potentially regulating the expression of functional genes (PIR, ACE2, and CLTRN) in multiple tissues and cell lines (p< 0.05).ConclusionThe ACE2 gene rs2106809 A>G variant is significantly associated with the risk of PE via individual locus effects and/or complex gene–gene and gene–environment interactions. Regulating the expression of functional genes such as PIR, ACE2, and CLTRN may be the molecular mechanism by which rs2106809 increases an individual’s susceptibility to PE.

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Association of IL-6 -176G > C Polymorphism with Susceptibility to Preeclampsia: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 25 publications

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

Association of IL-10 -819C/T, -592A/C polymorphisms with the risk of preeclampsia

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

Association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of pre-eclampsia

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