Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population

Aminkeng, Folefac; Weets, Ilse; Autreve, Jan E. Van; Koeleman, Bobby P. C.; Quartier, Erik; Schravendijk, Christiaan Van; Gorus, Frans; Auwera, Bart J. Van der; Registry, Belgian Diabetes

doi:10.1016/j.humimm.2010.09.006

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Since GWAS technology has been used for the study of complex disease genetics, T1D has been at the forefront of a rapidly moving field Craddock et al, 2010). GWAS studies have identified more than 50 loci that are associated with T1D, and this has led to our appreciation of the integral role of pathways within immune systems in the pathogenesis of T1D (Aminkeng et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta‐Analysis of 19,495 Cases and 25,341 Controls

Xuan

Liu

Zhao

et al. 2013

Annals of Human Genetics

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SummaryThe protein tyrosine phosphatase N22 (PTPN22) gene C1858T polymorphism has been reported to be associated with susceptibility to type 1 diabetes (T1D) in relatively small sample sizes. This study aimed at investigating the pooled association by carrying out a meta-analysis on the published studies. The Medline, EBSCO, and BIOSIS databases were searched to identify eligible studies published in English before June 2012. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI). The presence of heterogeneity and publication bias was explored by using meta-regression analysis and Begg's test, respectively. A total of 28 studies were involved in this meta-analysis. Across all populations, significant associations were found between the PTPN22 C1858T polymorphism and susceptibility to T1D under genotypic (TT vs. CC [OR = 3.656, 95% CI: 3.139-4.257], CT vs. CC [OR = 1.968, 95% CI: 1.683-2.300]), recessive (OR = 3.147, 95% CI: 2.704-3.663), and dominant models (OR = 1.957, 95% CI: 1.817-2.108). In ethnicityand sex-stratified analyses, similar associations were found among Caucasians and within Caucasian male and female strata. The meta-analysis results suggest that the PTPN22 C1858T polymorphism was associated with susceptibility to T1D among the Caucasian population, and males who carried the -1858T allele were more susceptible to T1D than females.

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Section: Discussionmentioning

confidence: 99%

PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta‐Analysis of 19,495 Cases and 25,341 Controls

Xuan

Liu

Zhao

et al. 2013

Annals of Human Genetics

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“…Likewise, the association with IL2RA polymorphisms in Japanese was restricted to patients with acute‐onset T1D, while older subjects, with slow‐onset disease, did not show the link (25). Another analysis, conducted in the Belgian cohort, also provided some data in support of the IL2RA role in timing of T1D onset (30). On the contrary, no IL2RA ‐related age‐at‐onset effect was noticed in our cohort, which comprised early‐onset diabetic subjects (mean age at diagnosis: 8.2 years; data not shown).…”

Section: Primer Sequences Pcr Conditions and Restriction Enzymes Usementioning

confidence: 93%

Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population

et al. 2011

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Polymorphic variants of the IL2RA gene, which encodes high-affinity alpha subunit (CD25) of the interleukin-2 receptor, were recently found to affect the risk of several autoimmune disorders. This study was aimed to investigate the association of selected IL2RA polymorphisms (rs11594656, rs3118470, rs2104286 and rs7093069) with type 1 diabetes (T1D) in a Polish cohort comprising 445 patients and 671 healthy control subjects. The minor A allele at rs11594656 was found significantly less frequently among T1D subjects, compared with the control group [P = 0.011; odds ratio (OR) = 0.77; 95% confidence interval (CI) = 0.629-0.942]. In contrast, the minor C allele at rs3118470 appeared to be significantly associated with the occurrence of T1D (P = 0.003; OR = 1.30; 95% CI = 1.094-1.550). Two other IL2RA single nucleotide polymorphisms (SNPs) did not show significant differences among investigated groups. In conclusion, the study confirms the association of the IL2RA locus with T1D in the Polish population.Type 1 diabetes (T1D) is an autoimmune disorder, which results from T-cell mediated destruction of the insulinsecreting pancreatic beta cells. Its aetiology seems influenced by a complex interaction of inherited and environmental factors. Alleles at the human leukocyte antigen (HLA) region (chromosome 6p21) display the strongest genetic contribution to T1D development. Moreover, robust data support a considerable role of several other genes, notably INS (11p15), PTPN22

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“…The association of the IL2RA locus with T1D was first investigated by Vella et al [4] using a multilocus tag single nucleotide polymorphism (SNP) approach, and subsequently replicated in three genome-wide association studies (GWAS), including WTCCC, GoKinD and NIMH, and several other case-control studies in T1D. Five common tag SNPs were mainly observed, which had no obvious linkage disequilibrium to each other [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. These are two intronic SNPs in the 5 0 region of IL2RA, rs706778 and rs3118470; two SNPs mapping to the 5 0 flanking region, rs41295061 (previously named ss52580101 or rs12722495) and rs11594656; and one SNP in the intron 1, rs2104286.…”

Section: Introductionmentioning

confidence: 99%

Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies

Tang

Cui

Jiang

et al. 2015

J Cellular Molecular Medi

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Single nucleotide polymorphisms (SNPs) in the interleukin 2 receptor alpha (IL2RA) gene have been suggested to be associated with type 1 diabetes (T1D) susceptibility. However, the results from individual studies are inconsistent. To explore the association of IL2RA polymorphisms with T1D, including rs11594656, rs2104286, rs3118470, rs41295061 and rs706778, a meta-analysis involving 10 independent studies with 19 outcomes was conducted: five studies with a total of 10,572 cases and 12,956 controls were analysed for rs11594656 with T1D risk, three studies with 7300 cases and 8331 controls for rs2104286, three studies with 3880 cases and 5409 controls for rs3118470, five studies with 11,253 cases and 13,834 controls for rs41295061 and three studies with 1896 cases and 1709 controls for rs706778 respectively. Using minor allelic comparison, the five investigated SNPs were all observed to have a significant association with T1D: For rs11594656, fixed effect model (FEM) odds ratio (OR) 0.87, 95% confidence interval (CI) 0.83, 0.91; rs2104286, FEM OR 0.81, 95% CI 0.77, 0.85; rs3118470, FEM OR 1.23, 95% CI 1.16, 1.31; rs41295061, random effect model (REM) OR 0.67, 95% CI 0.60, 0.76 and rs706778 FEM OR 1.20, 95% CI 1.08, 1.33. Similar results were obtained when all the included studies were calculated by a REM. Our meta-analysis suggests that all five SNPs in the IL2RA gene are risk factors for T1D risk, and rs11594656, rs2104286 and rs41295061 are the most associated SNPs in the populations investigated. This conclusion warrants confirmation by further studies.

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Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population

Cited by 8 publications

References 21 publications

PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta‐Analysis of 19,495 Cases and 25,341 Controls

PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta‐Analysis of 19,495 Cases and 25,341 Controls

Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population

Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies

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